Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Erbb4 tyrosine kinase receptor (Erbb-4) | Successful | Target Info | ||
| UniProt ID | ERBB4_HUMAN | ||||
| Gene Name | ERBB4 | ||||
| Gene ID | 2066 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Protein-tyrosine phosphatase SHP-2 (PTPN11) | Target Info | PPI Info | [2] | |
| Presynaptic density protein 95 (DLG4) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | E3 ubiquitin protein ligase Itchy (ITCH) | Target Info | PPI Info | [4] | |
| Yes-associated protein 1 (YAP1) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility. Sci Signal. 2014 Aug 19;7(339):ra78. | ||||
| REF 2 | A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360. | ||||
| REF 3 | The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3596-601. | ||||
| REF 4 | Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4162-7. | ||||
| REF 5 | The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. Mol Cell Biol. 2009 Feb;29(3):892-906. | ||||
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