Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T04507 Target Info
Target Name Presynaptic density protein 95 (DLG4)
Synonyms Synapse-associated protein 90; SAP90; SAP-90; Postsynaptic density-95; Postsynaptic density protein 95; PSD95; PSD-95; Disks large homolog 4; Discs, large homolog 4
Target Type Clinical trial Target
Gene Name DLG4
Biochemical Class Ezrin/radixin/moesin-binding phosphoprotein 50
UniProt ID
DLG4_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 6 Alpha-type channels +
Interacting Protein Name Potassium voltage-gated channel subfamily A member 4 (KCNA4) Interacting Protein Interacting Protein Info
UniProt ID
KCNA4_HUMAN 
Synonyms HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [2]
3 Reconstituted Complex [1]
4 Reconstituted Complex [3]
5 Reconstituted Complex [2]
6 Yeast two hybrid [1]
Interacting Target Name Glutamate receptor ionotropic NMDA 2A (NMDAR2A) Successful Target Interacting Protein Info
UniProt ID
NMDE1_HUMAN 
Synonyms NR2A; N-methyl D-aspartate receptor subtype 2A; NMDA receptor NR2A; HNR2A; Glutamate receptor ionotropic, NMDA 2A; Glutamate [NMDA] receptor subunit epsilon-1; GluN2A
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
4 Reconstituted Complex [7]
5 Reconstituted Complex [6]
Interacting Target Name Glutamate receptor ionotropic NMDA 2B (NMDAR2B) Successful Target Interacting Protein Info
UniProt ID
NMDE2_HUMAN 
Synonyms NR3; NR2B; N-methyl-D-aspartate receptor subunit 3; N-methylD-aspartate receptor subtype 2B; N-methyl D-aspartate receptor subtype 2B; NMDA receptor subunit 2B; NMDA receptor NR2B; NMDA NR2B receptor; HNR3; Glutamate receptor NR2B subunit; Glutamate receptor ionotropic, NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; GluN2B
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Far Western [9]
3 Reconstituted Complex [8]
4 Yeast two hybrid [7]
Interacting Target Name Voltage-gated potassium channel Kv1.5 (KCNA5) Successful Target Interacting Protein Info
UniProt ID
KCNA5_HUMAN 
Synonyms Voltage-gatedpotassium channel subunit Kv1.5; Voltage-gated potassium channel subunit Kv1.5; Voltage-gated potassium channel HK2; Potassium voltage-gated channel subfamily A member 5; Potassium channel Kv1.5; HPCN1; HK2; 02-Sensitive Potassium Channel Kv1.5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [1]
4 Yeast two hybrid [1]
Interacting Target Name Glutamate receptor ionotropic kainate 2 (GRIK2) Literature-reported Target Interacting Protein Info
UniProt ID
GRIK2_HUMAN 
Synonyms Glutamate receptor ionotropic, kainate 2; Glutamate receptor 6; GluR-6; GluR6; GluK2; Excitatory amino acid receptor 4; EAA4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [3]
Interacting Target Name Glutamate receptor ionotropic kainate 5 (GRIK5) Literature-reported Target Interacting Protein Info
UniProt ID
GRIK5_HUMAN 
Synonyms KA2; GRIK2; Glutamate receptor KA-2; Glutamate receptor ionotropic, kainate 5; GluK5; Excitatory amino acid receptor 2; EAA2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [12]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Adrenergic receptor beta-1 (ADRB1) Successful Target Interacting Protein Info
UniProt ID
ADRB1_HUMAN 
Synonyms Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [13]
4 Yeast two hybrid [13]
Kinases [+] 1 Kinases +
Interacting Target Name Erbb4 tyrosine kinase receptor (Erbb-4) Successful Target Interacting Protein Info
UniProt ID
ERBB4_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; P180erbB4; HER4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Co-fractionation [16]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Protein Name Disks large homolog 3 (DLG3) Interacting Protein Interacting Protein Info
UniProt ID
DLG3_HUMAN 
Synonyms MRX; MRX90; NEDLG; PPP1R82; SAP102; XLMR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Nitric-oxide synthase brain (NOS1) Clinical trial Target Interacting Protein Info
UniProt ID
NOS1_HUMAN 
Synonyms Peptidyl-cysteine S-nitrosylase NOS1; NOS, type I; NOS type I; N-NOS; NNOS; Nitric oxide synthase, brain; Neuronal NOS; NC-NOS; BNOS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Reconstituted Complex [20]
3 Yeast two hybrid [20]
Putative transporters [+] 1 Putative transporters +
Interacting Target Name LDL receptor related protein-2 (LRP-2) Literature-reported Target Interacting Protein Info
UniProt ID
LRP2_HUMAN 
Synonyms Megalin; Low-density lipoprotein receptor-related protein 2; Lowdensity lipoprotein receptorrelated protein 2; Gp330; Glycoprotein 330
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [22]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Disks large-associated protein 1 (DLGAP1) Interacting Protein Interacting Protein Info
UniProt ID
DLGP1_HUMAN 
Synonyms DAP.1; DAP.1.ALPHA; DAP.1.BETA; DAP1; DLGAP1A; DLGAP1B; GKAP; SAPAP1; hGKAP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [17]
3 Affinity Capture-Western [23]
4 Far Western [23]
5 Reconstituted Complex [24]
References  Top
REF 1 N-terminal PDZ-binding domain in Kv1 potassium channels. FEBS Lett. 2002 Nov 20;531(3):529-37.
REF 2 Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. J Biol Chem. 2002 Feb 1;277(5):3640-6.
REF 3 The PDZ1 domain of SAP90. Characterization of structure and binding. J Biol Chem. 2002 Mar 1;277(9):6967-73.
REF 4 Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. Brain Res. 2002 Nov 15;955(1-2):123-32.
REF 5 DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. Genes Cells. 1997 Jun;2(6):415-24.
REF 6 Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. J Biol Chem. 2002 Jun 14;277(24):21697-711.
REF 7 Binding of neuroligins to PSD-95. Science. 1997 Sep 5;277(5331):1511-5.
REF 8 Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995 Sep 22;269(5231):1737-40.
REF 9 Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996 Apr 1;16(7):2157-63.
REF 10 A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97. Biochem Biophys Res Commun. 2006 Mar 31;342(1):1-8.
REF 11 Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. J Biol Chem. 2001 May 11;276(19):16092-9.
REF 12 SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron. 1998 Oct;21(4):727-39.
REF 13 beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. J Biol Chem. 2000 Dec 8;275(49):38659-66.
REF 14 beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. J Biol Chem. 2001 Nov 2;276(44):41310-7.
REF 15 The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3596-601.
REF 16 Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 2000 May;26(2):443-55.
REF 17 Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8760-E8769.
REF 18 Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites. J Biol Chem. 1999 Feb 26;274(9):5782-90.
REF 19 CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron. 1998 Jan;20(1):115-24.
REF 20 Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell. 1996 Mar 8;84(5):757-67.
REF 21 Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins. Biochem J. 2003 Jul 15;373(Pt 2):381-91.
REF 22 Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem. 2000 Aug 18;275(33):25616-24.
REF 23 GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J Cell Biol. 1997 Feb 10;136(3):669-78.
REF 24 SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J Biol Chem. 1997 May 2;272(18):11943-51.

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