Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Beclin-1 (BECN1) | Literature-reported | Target Info | ||
| UniProt ID | BECN1_HUMAN | ||||
| Gene Name | BECN1 | ||||
| Gene ID | 8678 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Apoptosis regulator Bcl-2 (BCL-2) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | Apoptosis regulator Bcl-xL (BCL-xL) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | E3 ubiquitin-protein ligase NEDD4 (NEDD4) | Target Info | PPI Info | [3] | |
| Serine/threonine-protein kinase ULK1 (ULK1) | Target Info | PPI Info | [4] | ||
| Beclin-1 (BECN1) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J Biol Chem. 2010 Dec 3;285(49):38214-23. | ||||
| REF 2 | Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem. 2008 Sep 12;283(37):25596-605. | ||||
| REF 3 | The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Autophagy. 2017;13(12):2041-2055. | ||||
| REF 4 | RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell. 2011 Jan 21;144(2):253-67. | ||||
| REF 5 | TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal. 2010 May 25;3(123):ra42. | ||||
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