Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T79307 Target Info
Target Name Serine/threonine-protein kinase ULK1 (ULK1)
Synonyms hATG1; Unc-51-like kinase 1; KIAA0722; Autophagy-related protein 1 homolog; ATG1
Target Type Literature-reported Target
Gene Name ULK1
Biochemical Class Kinase
UniProt ID
ULK1_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Biochemical Activity [1]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Protein Name Gamma-aminobutyric acid receptor-associated protein (GABARAP) Interacting Protein Interacting Protein Info
UniProt ID
GBRAP_HUMAN 
Synonyms ATG8A; GABARAP.a; MM46
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [4]
Autophagy-related proteins [+] 2 Autophagy-related proteins +
Interacting Target Name Beclin-1 (BECN1) Literature-reported Target Interacting Protein Info
UniProt ID
BECN1_HUMAN 
Synonyms Protein GT197; GT197; Coiled-coil myosin-like BCL2-interacting protein; Coiledcoil myosinlike BCL2interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [6]
Interacting Protein Name RB1-inducible coiled-coil protein 1 (RB1CC1) Interacting Protein Interacting Protein Info
UniProt ID
RBCC1_HUMAN 
Synonyms ATG17; CC1; FIP200; PPP1R131
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Regulatory-associated protein of mTOR (RPTOR) Interacting Protein Interacting Protein Info
UniProt ID
RPTOR_HUMAN 
Synonyms KOG1; Mip1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Biochemical Activity [9]
Kinases [+] 2 Kinases +
Interacting Protein Name AMPK subunit gamma-1 (PRKAG1) Interacting Protein Interacting Protein Info
UniProt ID
AAKG1_HUMAN 
Synonyms AMPKG
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
Interacting Protein Name AMPK subunit alpha-1 (PRKAA1) Interacting Protein Interacting Protein Info
UniProt ID
AAPK1_HUMAN 
Synonyms AMPK; AMPKa1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
Phagophore-form transporters [+] 1 Phagophore-form transporters +
Interacting Protein Name Autophagy-related protein 13 (ATG13) Interacting Protein Interacting Protein Info
UniProt ID
ATG13_HUMAN 
Synonyms KIAA0652; PARATARG8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [8]
3 Biochemical Activity [11]
4 Biochemical Activity [9]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Protein Name Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) Interacting Protein Interacting Protein Info
UniProt ID
GBRL2_HUMAN 
Synonyms ATG8; ATG8C; GATE.16; GATE16; GEF.2; GEF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Yeast two hybrid [4]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) Interacting Protein Interacting Protein Info
UniProt ID
AMRA1_HUMAN 
Synonyms DCAF3; WDR94
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [12]
References  Top
REF 1 Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015 Feb 27;11(2):e1004987.
REF 2 Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014 Sep;281(17):3816-27.
REF 3 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 4 Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):1-12.
REF 5 RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell. 2011 Jan 21;144(2):253-67.
REF 6 TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Dev Cell. 2016 Oct 10;39(1):13-27.
REF 7 Network organization of the human autophagy system. Nature. 2010 Jul 1;466(7302):68-76.
REF 8 Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar;17(3):262-75.
REF 9 ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy. 2011 Jul;7(7):737-47.
REF 10 mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol. 2013 Apr;15(4):406-16.
REF 11 FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy. 2014 Oct 1;10(10):1749-60.
REF 12 The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol. 2010 Oct 4;191(1):155-68.

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