Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | Regulatory-associated protein of mTOR (RPTOR) | ||||
UniProt ID | RPTOR_HUMAN | ||||
Gene Name | RPTOR | ||||
Gene ID | 57521 |
Interacting TTD Target Information | Top | ||||
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Interacting Successful Target(s) | Serine/threonine-protein kinase mTOR (mTOR) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Extracellular signal-regulated kinase 2 (ERK2) | Target Info | PPI Info | [2] | |
Insulin receptor substrate-1 (IRS1) | Target Info | PPI Info | [5] | ||
Interacting Literature-reported Target(s) | Serine/threonine-protein kinase ULK1 (ULK1) | Target Info | PPI Info | [3] | |
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) | Target Info | PPI Info | [4] |
References | Top | ||||
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REF 1 | Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002 Jul 26;110(2):177-89. | ||||
REF 2 | ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). J Biol Chem. 2011 Jan 7;286(1):567-77. | ||||
REF 3 | Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar;17(3):262-75. | ||||
REF 4 | Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1. J Biol Chem. 2003 Oct 17;278(42):40717-22. | ||||
REF 5 | Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. J Biol Chem. 2009 Aug 21;284(34):22525-34. |
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