Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T84941 Target Info
Target Name Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Synonyms eIF4E-binding protein 1; Phosphorylated heat- andacid-stable protein regulated by insulin 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; 4E-BP1
Target Type Literature-reported Target
Gene Name EIF4EBP1
UniProt ID
4EBP1_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Regulatory-associated protein of mTOR (RPTOR) Interacting Protein Interacting Protein Info
UniProt ID
RPTOR_HUMAN 
Synonyms KOG1; Mip1
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Far Western [1]
9 Far Western [8]
10 Reconstituted Complex [1]
11 Reconstituted Complex [5]
Eukaryotic initiation factors [+] 1 Eukaryotic initiation factors +
Interacting Target Name Eukaryotic initiation factor 4E (EIF4E) Literature-reported Target Interacting Protein Info
UniProt ID
IF4E_HUMAN 
Synonyms Eukaryotic translation initiation factor 4E; eIF-4F 25 kDa subunit; eIF4F 25 kDa subunit; EIF4F; EIF4EL1; eIF-4E; eIF4E
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [12]
5 Affinity Capture-Western [2]
6 Affinity Capture-Western [3]
7 Co-fractionation [13]
8 Co-purification [14]
9 Reconstituted Complex [15]
10 Reconstituted Complex [16]
11 Reconstituted Complex [17]
12 Yeast two hybrid [18]
Kinases [+] 2 Kinases +
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [20]
3 Reconstituted Complex [5]
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [21]
2 Protein-peptide [22]
References  Top
REF 1 Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1. J Biol Chem. 2003 Oct 17;278(42):40717-22.
REF 2 Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem. 2006 Aug 25;281(34):24293-303.
REF 3 Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol. 2005 Apr;25(7):2558-72.
REF 4 TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol. 2003 May 13;13(10):797-806.
REF 5 Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002 Jul 26;110(2):177-89.
REF 6 The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem. 2003 May 2;278(18):15461-4.
REF 7 Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem. 2007 Jul 13;282(28):20534-43.
REF 8 cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. EMBO J. 2008 Apr 9;27(7):1005-16.
REF 9 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 10 Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells. Neoplasia. 2005 Oct;7(10):921-9.
REF 11 Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size. Genes Cells. 2006 Jul;11(7):757-66.
REF 12 Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men. Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E105-13.
REF 13 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 14 Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. Eur J Biochem. 2002 Jun;269(12):3076-85.
REF 15 Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR. FEBS Lett. 1999 Jun 25;453(3):387-90.
REF 16 Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods. Chem Pharm Bull (Tokyo). 2001 Oct;49(10):1299-303.
REF 17 Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. Biochem J. 2003 Aug 15;374(Pt 1):137-43.
REF 18 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2014 Apr 11;5:3650.
REF 19 mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 2002 Jul 26;110(2):163-75.
REF 20 Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science. 2007 Nov 9;318(5852):977-80.
REF 21 Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. J Biol Chem. 2000 Mar 17;275(11):7803-10.
REF 22 Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 1999 Dec 31;274(53):37538-43.

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