Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T96623 Target Info
Target Name Heat shock protein 90 beta (HSP90B)
Synonyms Heat shock 84 kDa; HSP84; HSP 84
Target Type Clinical trial Target
Gene Name HSP90AB1
Biochemical Class Heat shock protein
UniProt ID
HS90B_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Serine/threonine-protein phosphatase 5 (PPP5C) Patented-recorded Target Interacting Protein Info
UniProt ID
PPP5_HUMAN 
Synonyms Protein phosphatase T; PPT protein; PP-T; PPP5; PP5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Proximity Label-MS [3]
Interacting Target Name Phosphatase and tensin homolog (PTEN) Literature-reported Target Interacting Protein Info
UniProt ID
PTEN_HUMAN 
Synonyms TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [5]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-fractionation [7]
Isomerases [+] 2 Isomerases +
Interacting Target Name FK506-binding protein 4 (FKBP4) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP4_HUMAN 
Synonyms PPIase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4; P59 protein; p59; Immunophilin FKBP52; HSP-binding immunophilin; HSP binding immunophilin; HBI; FKBP59; FKBP52 protein; FKBP-52; FKBP52; FKBP-4; 59 kDa immunophilin; 52 kDa FKBP; 52 kDa FK506-binding protein; 52 kDa FK506 binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [8]
Interacting Target Name Rotamase D (PPID) Patented-recorded Target Interacting Protein Info
UniProt ID
PPID_HUMAN 
Synonyms PPIase D; Peptidylprolyl isomerase D; Peptidyl-prolyl cis-trans isomerase D; CYPD; CYP-40; CYP40; Cyclophilin-related protein; Cyclophilin-40; 40 kDa peptidyl-prolyl cis-trans isomerase
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [9]
2 Reconstituted Complex [10]
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [12]
3 Affinity Capture-Western [12]
4 Protein-Fragment Complementation Assay [11]
5 Yeast two hybrid [13]
Interacting Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target Interacting Protein Info
UniProt ID
BRAF_HUMAN 
Synonyms V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [14]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name HIF-prolyl hydroxylase 2 (HPH-2) Patented-recorded Target Interacting Protein Info
UniProt ID
EGLN1_HUMAN 
Synonyms SM-20; SM20; Prolyl hydroxylase domain-containing protein 2; Prolyl hydroxylase domaincontaining protein 2; PNAS-137; PNAS-118; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; Hypoxiainducible factor prolyl hydroxylase 2; HPH2; HIFprolyl hydroxylase 2; HIF-PH2; HIFPH2; Egl nine homolog 1; C1orf12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [16]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Other proteins [+] 1 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [19]
References  Top
REF 1 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 2 Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. Proteomics. 2011 Apr;11(8):1508-16.
REF 3 Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Cell Syst. 2017 Apr 26;4(4):430-444.e5.
REF 4 WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 2011 Jun;13(6):728-33.
REF 5 Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. Free Radic Biol Med. 2016 Jan;90:24-34.
REF 6 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Mol Cell Proteomics. 2010 Feb;9(2):255-70.
REF 7 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 8 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 9 Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40. Anal Biochem. 2011 Mar 15;410(2):257-65.
REF 10 Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress Chaperones. 2004 Summer;9(2):167-81.
REF 11 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 12 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem. 2003 Feb 14;278(7):5292-9.
REF 13 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 14 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34.
REF 15 Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway. J Biol Chem. 2013 Apr 5;288(14):9662-74.
REF 16 Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing. J Biol Chem. 2014 May 23;289(21):14656-65.
REF 17 COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70. PLoS One. 2009 Oct 5;4(10):e7332.
REF 18 MafG controls the hypoxic response of cells by accumulating HIF-1alpha in the nuclei. FEBS Lett. 2008 Jul 9;582(16):2357-64.
REF 19 Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15370-5.

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