Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Serine/threonine-protein kinase B-raf (BRAF) | Successful | Target Info | ||
| UniProt ID | BRAF_HUMAN | ||||
| Gene Name | BRAF | ||||
| Gene ID | 673 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Serine/threonine-protein kinase B-raf (BRAF) | Target Info | PPI Info | [1] | |
| RAC-alpha serine/threonine-protein kinase (AKT1) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | ERK activator kinase 1 (MEK1) | Target Info | PPI Info | [1] | |
| ERK activator kinase 2 (MEK2) | Target Info | PPI Info | [1] | ||
| Endoplasmic reticulum chaperone BiP (HSPA5) | Target Info | PPI Info | [1] | ||
| GTPase NRas (NRAS) | Target Info | PPI Info | [3] | ||
| Proto-oncogene c-RAF (c-RAF) | Target Info | PPI Info | [4] | ||
| GTPase KRas (KRAS) | Target Info | PPI Info | [5] | ||
| Heat shock protein 90 beta (HSP90B) | Target Info | PPI Info | [1] | ||
| Mortalin (HSPA9) | Target Info | PPI Info | [1] | ||
| Interacting Literature-reported Target(s) | Lipopolysaccharide-associated protein 1 (HSPA8) | Target Info | PPI Info | [1] | |
| GTPase HRas (HRAS) | Target Info | PPI Info | [6] | ||
| Hsp90 co-chaperone Cdc37 (CDC37) | Target Info | PPI Info | [1] | ||
| AS1 14-3-3 protein eta (YWHAH) | Target Info | PPI Info | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34. | ||||
| REF 2 | Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem. 2000 Sep 1;275(35):27354-9. | ||||
| REF 3 | Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems. J Biol Chem. 1995 Dec 1;270(48):28834-8. | ||||
| REF 4 | Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res. 2001 May 1;61(9):3595-8. | ||||
| REF 5 | Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4. | ||||
| REF 6 | Biochemical analysis of MEK activation in NIH3T3 fibroblasts. Identification of B-Raf and other activators. J Biol Chem. 1995 Mar 31;270(13):7644-55. | ||||
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