Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T48598 Target Info
Target Name GTPase KRas (KRAS)
Synonyms c-Ki-ras; c-K-ras; RASK2; Ki-Ras; KRAS2; K-Ras 2
Target Type Clinical trial Target
Gene Name KRAS
Biochemical Class Small GTPase
UniProt ID
RASK_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Elongation factor 1-alpha 1 (EEF1A1) Interacting Protein Interacting Protein Info
UniProt ID
EF1A1_HUMAN 
Synonyms CCS.3; CCS3; EE1A1; EEF.1; EEF1A; EF.Tu; EF1A; GRAF.1EF; HNGC:16303; LENG7; PTI1; eEF1A.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [2]
Kinases [+] 3 Kinases +
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Fluorescence Resonance Energy Transfer [4]
4 Yeast two hybrid [5]
Interacting Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target Interacting Protein Info
UniProt ID
BRAF_HUMAN 
Synonyms V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Fluorescence Resonance Energy Transfer [4]
Interacting Protein Name Proto-oncogene A-Raf (ARAF ) Interacting Protein Interacting Protein Info
UniProt ID
ARAF_HUMAN 
Synonyms Serine/threonine-protein kinase A-Raf; Proto-oncogene Pks; Proto-oncogene A-Raf-1; Proto-oncogene A-Raf; PKS2; PKS; ARAF1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Yeast two hybrid [7]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Ral guanine nucleotide dissociation stimulator (RALGDS) Interacting Protein Interacting Protein Info
UniProt ID
GNDS_HUMAN 
Synonyms RGDS; RGF; RalGEF
Evidence Score (E-score) 1 Experimental Evidences +
1 Yeast two hybrid [5]
References  Top
REF 1 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 2 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 3 Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol. 2005 Aug;7(8):837-43.
REF 4 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 5 The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev. 2000 Apr 15;14(8):895-900.
REF 6 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 7 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.

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