Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12817 Target Info
Target Name Lipopolysaccharide-associated protein 1 (HSPA8)
Synonyms LPS-associated protein 1; LAP-1; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8; HSPA10; HSP73; HSC70
Target Type Literature-reported Target
Gene Name HSPA8
Biochemical Class Heat shock protein
UniProt ID
HSP7C_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-fractionation [4]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-Western [7]
5 Protein-peptide [8]
6 Reconstituted Complex [9]
7 Reconstituted Complex [10]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
Alkyl/aryl transferases [+] 1 Alkyl/aryl transferases +
Interacting Target Name Geranyltranstransferase (FDPS) Successful Target Interacting Protein Info
UniProt ID
FPPS_HUMAN 
Synonyms KIAA1293; GGPS1; GGPPSase; GGPP synthase; Geranylgeranyl pyrophosphate synthase; Geranylgeranyl diphosphate synthase; FPS protein; FPP synthase; Farnesyltranstransferase; Farnesyl pyrophosphate synthase; Farnesyl diphosphate synthase; Dimethylallyltranstransferase; (2E,6E)-farnesyl diphosphate synthase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-fractionation [2]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target Interacting Protein Info
UniProt ID
KCNH2_HUMAN 
Synonyms Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; hERG-1; hERG1; HERG K+ channel; H-ERG; HERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; ERG-1; Erg1; ERG; Eag related protein 1; Eag homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [14]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Phosphatase and tensin homolog (PTEN) Literature-reported Target Interacting Protein Info
UniProt ID
PTEN_HUMAN 
Synonyms TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; MMAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Reconstituted Complex [16]
FAM proteins [+] 1 FAM proteins +
Interacting Protein Name Hsc70-interacting protein (ST13) Interacting Protein Interacting Protein Info
UniProt ID
F10A1_HUMAN 
Synonyms AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP; HSPABP1; P48; PRO0786; SNC6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [7]
4 Reconstituted Complex [17]
Heat shock proteins [+] 5 Heat shock proteins +
Interacting Protein Name Heat shock protein 105 kDa (HSPH1) Interacting Protein Interacting Protein Info
UniProt ID
HS105_HUMAN 
Synonyms HSP105; HSP105A; HSP105B; NY.CO.25
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Co-fractionation [2]
Interacting Protein Name Heat shock 70 kDa protein 4L (HSPA4L) Interacting Protein Interacting Protein Info
UniProt ID
HS74L_HUMAN 
Synonyms APG.1; HSPH3; Osp94
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Co-fractionation [2]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Co-fractionation [2]
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [19]
Interacting Protein Name Heat shock-related 70 kDa protein 2 (HSPA2) Interacting Protein Interacting Protein Info
UniProt ID
HSP72_HUMAN 
Synonyms HSP70.2; HSP70.3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [11]
3 Affinity Capture-MS [5]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Target Name cAMP-dependent chloride channel (CFTR) Successful Target Interacting Protein Info
UniProt ID
CFTR_HUMAN 
Synonyms Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; cAMP-dependent chloride channel; cAMPdependent chloride channel; ATP-binding cassette sub-family C member 7; ATPbinding cassette subfamily C member 7; ABCC7
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [20]
2 Affinity Capture-Western [21]
3 Affinity Capture-Western [20]
4 Affinity Capture-Western [22]
5 Affinity Capture-Western [23]
6 Reconstituted Complex [24]
Kinases [+] 6 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [25]
2 Affinity Capture-MS [26]
3 Protein-Fragment Complementation Assay [27]
4 Yeast two hybrid [28]
Interacting Target Name DNA-dependent protein kinase catalytic (PRKDC) Clinical trial Target Interacting Protein Info
UniProt ID
PRKDC_HUMAN 
Synonyms P460; HYRC1; HYRC; DNPK1; DNA-PKcs; DNA-PK catalytic subunit; DNA-PK; DNA-dependent protein kinase catalytic subunit; DNA-dependent protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-fractionation [4]
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Affinity Capture-Western [30]
Interacting Target Name Leucine-rich repeat kinase 2 (LRRK2) Clinical trial Target Interacting Protein Info
UniProt ID
LRRK2_HUMAN 
Synonyms PARK8; LRRK2 S935 phosphorylation; LRRK2 G2019S mutation; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [31]
2 Affinity Capture-Western [32]
Interacting Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target Interacting Protein Info
UniProt ID
BRAF_HUMAN 
Synonyms V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [33]
Interacting Target Name ERK activator kinase 1 (MEK1) Clinical trial Target Interacting Protein Info
UniProt ID
MP2K1_HUMAN 
Synonyms PRKMK1; MKK1; Mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERKkinase 1; MAPK/ERK kinase 1; MAP kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [33]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Microtubule-associated protein tau (MAPT) Clinical trial Target Interacting Protein Info
UniProt ID
TAU_HUMAN 
Synonyms tau; TAU; Paired helical filament-tau; Paired helical filamenttau; Neurofibrillary tangle protein; MTBT1; Microtubule-associated protein tau; MAPTL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [34]
2 Affinity Capture-Western [35]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [36]
2 Affinity Capture-Western [37]
Peptidases [+] 1 Peptidases +
Interacting Target Name Ubiquitin thioesterase L1 (UCHL1) Preclinical Target Interacting Protein Info
UniProt ID
UCHL1_HUMAN 
Synonyms UCH-L1; Ubiquitin thiolesterase L1; Ubiquitin carboxy-terminal hydrolase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [38]
2 Reconstituted Complex [39]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [40]
2 Affinity Capture-Western [41]
3 Affinity Capture-Western [42]
Ribosomal proteins [+] 2 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein uL2 (RPL8) Interacting Protein Interacting Protein Info
UniProt ID
RL8_HUMAN 
Synonyms L8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-fractionation [4]
Interacting Protein Name Small ribosomal subunit protein uS8 (RPS15A) Interacting Protein Interacting Protein Info
UniProt ID
RS15A_HUMAN 
Synonyms S15a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-fractionation [4]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Erythroid differentiation-related factor 1 (EDRF1) Interacting Protein Interacting Protein Info
UniProt ID
EDRF1_HUMAN 
Synonyms C10orf137
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [11]
3 Affinity Capture-MS [5]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [43]
2 Affinity Capture-Western [44]
Interacting Protein Name Ubiquitin-like protein ISG15 (ISG15) Interacting Protein Interacting Protein Info
UniProt ID
ISG15_HUMAN 
Synonyms UCRP; Ubiquitin-like protein ISG15; Ubiquitin cross-reactive protein; IP17; Interferon-induced 17 kDa protein; Interferon-induced 15 kDa protein; hUCRP; G1P2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [45]
2 Affinity Capture-Western [46]
Virus penitration channels [+] 1 Virus penitration channels +
Interacting Protein Name DnaJ homolog subfamily B member 12 (DNAJB12) Interacting Protein Interacting Protein Info
UniProt ID
DJB12_HUMAN 
Synonyms DJ10
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
Other proteins [+] 19 Other proteins +
Interacting Protein Name BAG family molecular chaperone regulator 2 (BAG2) Interacting Protein Interacting Protein Info
UniProt ID
BAG2_HUMAN 
Synonyms BAG.2; dJ417I1.2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Co-fractionation [2]
5 Yeast two hybrid [47]
6 Yeast two hybrid [48]
Interacting Protein Name BAG family molecular chaperone regulator 1 (BAG1) Interacting Protein Interacting Protein Info
UniProt ID
BAG1_HUMAN 
Synonyms BAG.1; HAP; RAP46
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [40]
2 Protein-peptide [49]
3 Reconstituted Complex [50]
4 Reconstituted Complex [51]
5 Reconstituted Complex [52]
Interacting Protein Name BAG family molecular chaperone regulator 3 (BAG3) Interacting Protein Interacting Protein Info
UniProt ID
BAG3_HUMAN 
Synonyms BAG.3; BIS; CAIR.1; MFM6
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Yeast two hybrid [47]
5 Yeast two hybrid [53]
Interacting Protein Name Hsp70-binding protein 1 (HSPBP1) Interacting Protein Interacting Protein Info
UniProt ID
HPBP1_HUMAN 
Synonyms FES1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [11]
3 Affinity Capture-MS [5]
4 Yeast two hybrid [54]
5 Yeast two hybrid [53]
Interacting Protein Name Stress-induced-phosphoprotein 1 (STIP1) Interacting Protein Interacting Protein Info
UniProt ID
STIP1_HUMAN 
Synonyms HEL.S.94n; HOP; IEF.SSP.3521; P60; STI1; STI1L
Evidence Score (E-score) 5 Experimental Evidences +
1 Co-fractionation [2]
2 Co-fractionation [4]
3 Far Western [55]
4 Reconstituted Complex [56]
5 Reconstituted Complex [17]
Interacting Target Name Synuclein alpha (SNCA) Clinical trial Target Interacting Protein Info
UniProt ID
SYUA_HUMAN 
Synonyms PARK1; Non-A4 component of amyloid precursor; NonA4 component of amyloid precursor; Non-A beta component of AD amyloid; NonA beta component of AD amyloid; NACP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Protein-peptide [58]
3 Reconstituted Complex [59]
Interacting Protein Name BAG family molecular chaperone regulator 4 (BAG4) Interacting Protein Interacting Protein Info
UniProt ID
BAG4_HUMAN 
Synonyms BAG.4; SODD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Reconstituted Complex [60]
Interacting Protein Name DnaJ homolog subfamily A member 1 (DNAJA1) Interacting Protein Interacting Protein Info
UniProt ID
DNJA1_HUMAN 
Synonyms DJ.2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ.2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
Interacting Protein Name DnaJ homolog subfamily A member 2 (DNAJA2) Interacting Protein Interacting Protein Info
UniProt ID
DNJA2_HUMAN 
Synonyms CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
Interacting Protein Name Protein transport protein Sec24C (SEC24C) Interacting Protein Interacting Protein Info
UniProt ID
SC24C_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Co-fractionation [4]
Interacting Protein Name Tubulin alpha-1A chain (TUBA1A) Interacting Protein Interacting Protein Info
UniProt ID
TBA1A_HUMAN 
Synonyms B.ALPHA.1; LIS3; TUBA3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [5]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [61]
2 Reconstituted Complex [62]
Interacting Target Name Heat shock protein 40 (HSP40) Literature-reported Target Interacting Protein Info
UniProt ID
DNJB1_HUMAN 
Synonyms HSP40; Heat shock 40 kDa protein 1; HDJ-1; DNAJB1; DnaJ protein homolog 1; DnaJ homolog subfamily B member 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [17]
Interacting Target Name Epithelial cadherin (CDH1) Literature-reported Target Interacting Protein Info
UniProt ID
CADH1_HUMAN 
Synonyms Uvomorulin; UVO; E-cadherin gene; E-cadherin; CDHE; CD324; CAM 120/80; Cadherin-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [63]
2 Proximity Label-MS [64]
Interacting Protein Name DnaJ homolog subfamily C member 13 (DNAJC13) Interacting Protein Interacting Protein Info
UniProt ID
DJC13_HUMAN 
Synonyms RME8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Co-fractionation [2]
Interacting Protein Name DnaJ homolog subfamily C member 7 (DNAJC7) Interacting Protein Interacting Protein Info
UniProt ID
DNJC7_HUMAN 
Synonyms DJ11; DJC7; TPR2; TTC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Reconstituted Complex [56]
Interacting Protein Name Vpu-binding protein (SGTA) Interacting Protein Interacting Protein Info
UniProt ID
SGTA_HUMAN 
Synonyms SGT; alphaSGT; hSGT
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [56]
2 Yeast two hybrid [65]
Interacting Protein Name Tubulin beta chain (TUBB) Interacting Protein Interacting Protein Info
UniProt ID
TBB5_HUMAN 
Synonyms CDCBM6; M40; OK/SW.cl.56; TUBB1; TUBB5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-fractionation [2]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [66]
References  Top
REF 1 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 2 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 3 Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J Biol Chem. 2006 Jun 23;281(25):17369-78.
REF 4 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 5 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 6 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 7 ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation. Nat Commun. 2016 Oct 6;7:12882.
REF 8 Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics. 2006 Feb;5(2):234-44.
REF 9 Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem. 2011 May 6;286(18):15883-94.
REF 10 The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 2013 Aug 13;52(32):5354-64.
REF 11 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 12 5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer. Cancer Lett. 2017 Aug 1;400:183-193.
REF 13 Co-chaperone FKBP38 promotes HERG trafficking. J Biol Chem. 2007 Aug 10;282(32):23509-16.
REF 14 Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels. J Biol Chem. 2017 Feb 10;292(6):2287-2300.
REF 15 WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 2011 Jun;13(6):728-33.
REF 16 Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. Free Radic Biol Med. 2016 Jan;90:24-34.
REF 17 Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70. Mol Pharmacol. 2000 Dec;58(6):1257-63.
REF 18 Platelet adhesion to collagen under flow causes dissociation of a phosphoprotein complex of heat-shock proteins and protein phosphatase 1. Blood. 1997 Aug 15;90(4):1516-26.
REF 19 Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012 Jun;1823(6):1092-101.
REF 20 The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol. 2001 Jan;3(1):100-5.
REF 21 Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Am J Physiol Cell Physiol. 2000 Feb;278(2):C259-67.
REF 22 Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell. 2011 Aug 15;22(16):2797-809.
REF 23 Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase. J Biol Chem. 2013 Oct 25;288(43):31069-79.
REF 24 Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate. J Biol Chem. 2000 Dec 1;275(48):37462-8.
REF 25 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 26 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem. 2003 Feb 14;278(7):5292-9.
REF 27 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal. 2009 Dec 22;2(102):ra84.
REF 28 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 29 Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell. 2005 Oct;16(10):4733-44.
REF 30 The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Cell Mol Life Sci. 2010 Mar;67(6):995-1004.
REF 31 Identification of potential protein interactors of Lrrk2. Parkinsonism Relat Disord. 2007 Oct;13(7):382-5.
REF 32 The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci. 2008 Mar 26;28(13):3384-91.
REF 33 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34.
REF 34 CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem. 2004 Feb 6;279(6):4869-76.
REF 35 BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. J Biol Chem. 2007 Dec 21;282(51):37276-84.
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