Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | ERK activator kinase 1 (MEK1) | Clinical trial | Target Info | ||
UniProt ID | MP2K1_HUMAN | ||||
Gene Name | MAP2K1 | ||||
Gene ID | 5604 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Serine/threonine-protein kinase B-raf (BRAF) | Target Info | PPI Info | [1] | |
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | ERK activator kinase 1 (MEK1) | Target Info | PPI Info | [1] | |
Extracellular signal-regulated kinase 2 (ERK2) | Target Info | PPI Info | [3] | ||
Extracellular signal-regulated kinase 1 (ERK1) | Target Info | PPI Info | [4] | ||
Proto-oncogene c-RAF (c-RAF) | Target Info | PPI Info | [5] | ||
Interacting Literature-reported Target(s) | Lipopolysaccharide-associated protein 1 (HSPA8) | Target Info | PPI Info | [1] | |
Kinase suppressor of Ras-1 (KSR1) | Target Info | PPI Info | [1] | ||
Yes-associated protein 1 (YAP1) | Target Info | PPI Info | [6] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34. | ||||
REF 2 | The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor through spatial relocalization at helix 7 of its ligand-binding domain. Mol Cell Biol. 2011 Aug;31(16):3497-510. | ||||
REF 3 | p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels. Mol Cell Biol. 2003 May;23(9):3079-90. | ||||
REF 4 | MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science. 1998 Sep 11;281(5383):1668-71. | ||||
REF 5 | G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals. Mol Cell Biol. 2000 Sep;20(18):6837-48. | ||||
REF 6 | MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. FEBS Lett. 2013 Dec 11;587(24):3921-7. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.