Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Polycomb complex protein BMI-1 (BMI1) | Clinical trial | Target Info | ||
| UniProt ID | BMI1_HUMAN | ||||
| Gene Name | BMI1 | ||||
| Gene ID | 648 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Preclinical Target(s) | Herpesvirus ubiquitin-specific protease (HAUSP) | Target Info | PPI Info | [1] | |
| Interacting Literature-reported Target(s) | X-ray repair cross-complementing 5 (Ku80) | Target Info | PPI Info | [2] | |
| Chromobox protein homolog 7 (CBX7) | Target Info | PPI Info | [4] | ||
| Gamma-Histone H2AX (H2AFX) | Target Info | PPI Info | [5] | ||
| Interacting Clinical trial Target(s) | Polycomb complex protein BMI-1 (BMI1) | Target Info | PPI Info | [3] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J. 2010 Aug 4;29(15):2553-65. | ||||
| REF 2 | BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J Neurosci. 2010 Jul 28;30(30):10096-111. | ||||
| REF 3 | PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell. 2012 Feb 10;45(3):344-56. | ||||
| REF 4 | Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One. 2009 Jul 28;4(7):e6380. | ||||
| REF 5 | Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem. 2011 Aug 12;286(32):28599-607. | ||||
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