Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12808 | Target Info | |||
| Target Name | Protein kinase C alpha (PRKCA) | ||||
| Synonyms | Protein kinase C alpha type; PRKACA; PKCalpha; PKCA; PKC-alpha; PKC-A | ||||
| Target Type | Successful Target | ||||
| Gene Name | PRKCA | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Carbon-nitrogen hydrolases | [+] 1 Carbon-nitrogen hydrolases | + | |||
| Interacting Target Name | Histone deacetylase 6 (HDAC6) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | KIAA0901; JM21; HD6 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Biochemical Activity | [1] | |||
| 3 | Reconstituted Complex | [2] | |||
| Histones | [+] 2 Histones | + | |||
| Interacting Protein Name | Histone H1.1 (HIST1H1A) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | H1.1; H1A; H1F1; HIST1 | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [3] | |||
| Interacting Protein Name | Histone H1.5 (HIST1H1B) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | H1; H1.5; H1B; H1F5; H1s.3 | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [3] | |||
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Luminescence | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Protein-Fragment Complementation Assay | [4] | |||
| 4 | Yeast two hybrid | [6] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Target Name | Target of rapamycin complex 2 MAPKAP1 (MTORC2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | TORC2 subunit MAPKAP1; Target of rapamycin complex 2 subunit MAPKAP1; Stress-activated map kinase-interacting protein 1; SIN1; SAPK-interacting protein 1; mSIN1; Mitogen-activated protein kinase 2-associated protein 1; MIP1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Reconstituted Complex | [8] | |||
| 3 | Yeast two hybrid | [8] | |||
| Interacting Target Name | ELAV-like protein 1 (ELAVL1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HuR; Hu-antigen R | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and -catenin. EMBO J. 2011 Sep 27;30(23):4838-49. | ||||
| REF 2 | Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74. | ||||
| REF 3 | High-throughput kinase assays with protein substrates using fluorescent polymer superquenching. BMC Biotechnol. 2005 May 31;5:16. | ||||
| REF 4 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
| REF 5 | Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor. Biochem Biophys Res Commun. 2003 Aug 8;307(4):839-46. | ||||
| REF 6 | In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84. | ||||
| REF 7 | Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23;27(14):1919-31. | ||||
| REF 8 | Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. Elife. 2017 Mar 7;6. pii: e19594. | ||||
| REF 9 | The mRNA-stabilizing factor HuR protein is targeted by -TrCP protein for degradation in response to glycolysis inhibition. J Biol Chem. 2012 Dec 21;287(52):43639-50. | ||||
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