Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Linear ubiquitin chain assembly complex (RBCK1) | Literature-reported | Target Info | ||
| UniProt ID | HOIL1_HUMAN | ||||
| Gene Name | RBCK1 | ||||
| Gene ID | 10616 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Estrogen receptor (ESR) | Target Info | PPI Info | [1] | |
| Tumor necrosis factor (TNF) | Target Info | PPI Info | [2] | ||
| Interacting Clinical trial Target(s) | Protein kinase C beta (PRKCB) | Target Info | PPI Info | [3] | |
| Interacting Patented-recorded Target(s) | Polyubiquitin-C (UBC) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | Linear ubiquitin chain assembly complex (RBCK1) | Target Info | PPI Info | [4] | |
| Zinc finger protein A20 (TNFAIP3) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Estrogen receptor-, RBCK1, and protein kinase C 1 cooperate to regulate estrogen receptor- gene expression. J Mol Endocrinol. 2012 Oct 30;49(3):277-87. | ||||
| REF 2 | Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44. | ||||
| REF 3 | RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. J Biol Chem. 2007 Jan 19;282(3):1650-7. | ||||
| REF 4 | Cytoplasmic tethering of a RING protein RBCK1 by its splice variant lacking the RING domain. Biochem Biophys Res Commun. 2005 Sep 23;335(2):550-7. | ||||
| REF 5 | A20 inhibits LUBAC-mediated NF-B activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J. 2012 Oct 3;31(19):3845-55. | ||||
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