Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T56474 Target Info
Target Name Zinc finger protein A20 (TNFAIP3)
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Target Type Literature-reported Target
Gene Name TNFAIP3
Biochemical Class Acyltransferase
UniProt ID
TNAP3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 4 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
4 Biochemical Activity [4]
5 Yeast two hybrid [5]
6 Yeast two hybrid [6]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Yeast two hybrid [7]
5 Yeast two hybrid [10]
Interacting Protein Name E3 ubiquitin-protein ligase RNF114 (RNF114) Interacting Protein Interacting Protein Info
UniProt ID
RN114_HUMAN 
Synonyms PSORS12; ZNF313
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [12]
4 Yeast two hybrid [12]
Interacting Target Name Linear ubiquitin chain assembly complex (RBCK1) Literature-reported Target Interacting Protein Info
UniProt ID
HOIL1_HUMAN 
Synonyms XAP4; XAP3; Ubiquitin-conjugating enzyme 7-interacting protein 3; UBCE7IP3; RNF54; RING-type E3 ubiquitin transferase HOIL-1; RING finger protein 54; RanBP-type and C3HC4-type zinc finger-containing protein 1; HOIL-1; Hepatitis B virus X-associated protein 4; Heme-oxidized IRP2 ubiquitin ligase 1; HBV-associated factor 4; C20orf18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Yeast two hybrid [5]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [14]
3 Yeast two hybrid [15]
4 Yeast two hybrid [16]
5 Yeast two hybrid [14]
Kinases [+] 4 Kinases +
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [18]
3 Co-localization [17]
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [19]
3 Biochemical Activity [20]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [22]
Interacting Target Name NF-kappa-B-activating kinase (TBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
TBK1_HUMAN 
Synonyms TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [24]
Peptidases [+] 1 Peptidases +
Interacting Target Name Caspase-8 (CASP8) Patented-recorded Target Interacting Protein Info
UniProt ID
CASP8_HUMAN 
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Reconstituted Complex [25]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Affinity Capture-Western [27]
Proteins 14-3-3 [+] 3 Proteins 14-3-3 +
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [14]
4 Reconstituted Complex [14]
5 Yeast two hybrid [15]
6 Yeast two hybrid [14]
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [14]
4 Yeast two hybrid [14]
5 Yeast two hybrid [28]
Interacting Protein Name 14-3-3 protein epsilon (YWHAE) Interacting Protein Interacting Protein Info
UniProt ID
1433E_HUMAN 
Synonyms 14.3.3E; HEL2; KCIP.1; MDCR; MDS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Yeast two hybrid [16]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 13 Experimental Evidences +
1 Biochemical Activity [2]
2 Biochemical Activity [29]
3 Biochemical Activity [4]
4 Biochemical Activity [30]
5 Biochemical Activity [31]
6 Co-crystal Structure [32]
7 Co-crystal Structure [33]
8 Co-crystal Structure [34]
9 Reconstituted Complex [33]
10 Reconstituted Complex [13]
11 Reconstituted Complex [35]
12 Reconstituted Complex [28]
13 Reconstituted Complex [34]
Other proteins [+] 5 Other proteins +
Interacting Protein Name TNFAIP3-interacting protein 1 (TNIP1) Interacting Protein Interacting Protein Info
UniProt ID
TNIP1_HUMAN 
Synonyms ABIN.1; NAF1; VAN; nip40.1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Affinity Capture-Western [37]
3 Affinity Capture-Western [38]
4 Yeast two hybrid [36]
5 Yeast two hybrid [10]
6 Yeast two hybrid [16]
7 Yeast two hybrid [12]
8 Yeast two hybrid [28]
Interacting Protein Name Tax1-binding protein 1 (TAX1BP1) Interacting Protein Interacting Protein Info
UniProt ID
TAXB1_HUMAN 
Synonyms CALCOCO3; T6BP; TXBP151
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [37]
3 Affinity Capture-Western [1]
4 Yeast two hybrid [39]
Interacting Protein Name TNFAIP3-interacting protein 2 (TNIP2) Interacting Protein Interacting Protein Info
UniProt ID
TNIP2_HUMAN 
Synonyms ABIN2; FLIP1; KLIP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Affinity Capture-Western [37]
3 Affinity Capture-Western [41]
4 Yeast two hybrid [28]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [42]
2 Affinity Capture-Western [33]
3 Reconstituted Complex [35]
Interacting Protein Name TNFAIP3-interacting protein 3 (TNIP3) Interacting Protein Interacting Protein Info
UniProt ID
TNIP3_HUMAN 
Synonyms ABIN.3; LIND
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Yeast two hybrid [10]
References  Top
REF 1 Expression of the nuclear factor-B inhibitor A20 is altered in the cystic fibrosis epithelium. Eur Respir J. 2013 Jun;41(6):1315-23.
REF 2 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
REF 3 Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol. 2008 Feb 15;376(2):526-40.
REF 4 The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol. 2004 Oct;5(10):1052-60.
REF 5 Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem. 2012 Dec 14;287(51):43007-18.
REF 6 YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-B. Elife. 2017 Feb 28;6. pii: e22416.
REF 7 The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6721-5.
REF 8 Involvement of A20 in the molecular switch that activates the non-canonical NF-B pathway. Sci Rep. 2013;3:2568.
REF 9 The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex. Virology. 1999 Nov 10;264(1):159-66.
REF 10 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 11 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 12 The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-B activity and T-cell activation. Cell Death Dis. 2014 Aug 28;5:e1399.
REF 13 A20 inhibits LUBAC-mediated NF-B activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J. 2012 Oct 3;31(19):3845-55.
REF 14 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J Biol Chem. 1996 Aug 16;271(33):20029-34.
REF 15 A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem Biophys Res Commun. 1997 Sep 18;238(2):590-4.
REF 16 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 17 TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015;11(7):1052-62.
REF 18 TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. Autophagy. 2018;14(9):1629-1643.
REF 19 De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature. 2004 Aug 5;430(7000):694-9.
REF 20 A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov. 2012 Feb;2(2):140-55.
REF 21 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem. 2011 Mar 11;286(10):7905-16.
REF 22 A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome. Cytokine. 2001 Sep 21;15(6):282-98.
REF 23 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 24 ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. J Biol Chem. 2011 Oct 21;286(42):36592-602.
REF 25 Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-B and caspase-8-dependent apoptotic cell death. Cell Death Differ. 2017 Sep;24(9):1621-1631.
REF 26 Bladder polypoid cystitis-derived A20 associates with tumorigenesis. Cell Biochem Biophys. 2013 Nov;67(2):669-73.
REF 27 Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells. J Biomed Sci. 2013 Oct 7;20:74.
REF 28 Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain. Biochim Biophys Acta. 2008 May;1783(5):826-37.
REF 29 Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009 May;10(5):466-73.
REF 30 OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 2013 Jul 3;154(1):169-84.
REF 31 Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J. 2004 Mar 15;378(Pt 3):727-34.
REF 32 Ubiquitin binding to A20 ZnF4 is required for modulation of NF-B signaling. Mol Cell. 2010 Nov 24;40(4):548-57.
REF 33 Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-B regulation. EMBO J. 2012 Oct 3;31(19):3856-70.
REF 34 Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature. 2016 Oct 20;538(7625):402-405.
REF 35 Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011 Nov 18;44(4):559-71.
REF 36 The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J Cell Biol. 1999 Jun 28;145(7):1471-82.
REF 37 Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. FEBS Lett. 2001 Jun 1;498(1):93-7.
REF 38 Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. FEBS Lett. 2003 Feb 11;536(1-3):135-40.
REF 39 The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90.
REF 40 Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. J Biol Chem. 2001 Aug 10;276(32):30216-23.
REF 41 A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma. Clin Cancer Res. 2011 Mar 15;17(6):1440-51.
REF 42 SPATA2 links CYLD to the TNF- receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016 Sep 1;35(17):1868-84.
REF 43 LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation. J Biol Chem. 2007 Jan 5;282(1):81-90.

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