Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | Ataxin-3 (ATXN3) | ||||
UniProt ID | ATX3_HUMAN | ||||
Gene Name | ATXN3 | ||||
Gene ID | 4287 |
Interacting TTD Target Information | Top | ||||
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Interacting Clinical trial Target(s) | Glycogen synthase kinase-3 beta (GSK-3B) | Target Info | PPI Info | [1] | |
Valosin-containing protein p97 (VCP) | Target Info | PPI Info | [2] | ||
Histone deacetylase 3 (HDAC3) | Target Info | PPI Info | [3] | ||
Interacting Patented-recorded Target(s) | Polyubiquitin-C (UBC) | Target Info | PPI Info | [4] |
References | Top | ||||
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REF 1 | Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3. Biochem Biophys Res Commun. 2007 Jun 1;357(2):487-92. | ||||
REF 2 | Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun. 2016 Oct 20;7:13047. | ||||
REF 3 | Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. J Neurosci. 2006 Nov 1;26(44):11474-86. | ||||
REF 4 | Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51. |
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