| References |
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| REF 1 |
VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. PLoS One. 2013;8(1):e55724.
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| REF 2 |
Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
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| REF 3 |
Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. J Biol Chem. 2007 Nov 23;282(47):33908-14.
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| REF 4 |
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem. 2004 Oct 29;279(44):45676-84.
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| REF 5 |
Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. PLoS One. 2010 Jan 26;5(1):e8905.
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| REF 6 |
Vectors for co-expression of an unrestricted number of proteins. Nucleic Acids Res. 2007;35(6):e43.
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| REF 7 |
The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. J Biol Chem. 2011 Nov 4;286(44):38679-90.
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| REF 8 |
A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization. Int J Biochem Cell Biol. 2013 Apr;45(4):773-82.
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| REF 9 |
Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP. Biochim Biophys Acta. 2013 Dec;1834(12):2672-8.
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| REF 10 |
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics. 2006 Feb;5(2):234-44.
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| REF 11 |
mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response. Mol Cell Biol. 2018 Jan 29;38(4). pii: e00364-17.
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| REF 12 |
VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells. DNA Cell Biol. 2000 May;19(5):253-63.
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| REF 13 |
Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin. J Biol Chem. 2006 Apr 28;281(17):11610-7.
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| REF 14 |
Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. J Biol Chem. 2004 Dec 3;279(49):51376-85.
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| REF 15 |
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell. 2008 Sep 5;134(5):804-16.
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| REF 16 |
Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Nat Cell Biol. 2015 Oct;17(10):1356-69.
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| REF 17 |
Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1705-14.
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| REF 18 |
A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
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| REF 19 |
Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. J Biol Chem. 2013 Mar 8;288(10):7363-72.
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| REF 20 |
Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. J Biol Chem. 2013 Nov 15;288(46):33462-9.
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| REF 21 |
Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
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| REF 22 |
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
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| REF 23 |
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1.
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| REF 24 |
Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. J Proteomics. 2015 Jun 18;123:42-53.
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| REF 25 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 26 |
LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
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| REF 27 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
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| REF 28 |
Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol. 2013 Aug;27(8):1245-66.
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| REF 29 |
VCP/p97 regulates 2AR quality control during receptor biosynthesis. Cell Signal. 2017 Jan;30:50-58.
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| REF 30 |
Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J Biol Chem. 2006 Jun 23;281(25):17369-78.
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| REF 31 |
A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
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| REF 32 |
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun. 2016 Oct 20;7:13047.
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| REF 33 |
Imbalances in p97 co-factor interactions in human proteinopathy. EMBO Rep. 2010 Jun;11(6):479-85.
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| REF 34 |
ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif. J Biol Chem. 2005 Dec 16;280(50):41332-41.
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| REF 35 |
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem. 2004 Nov 26;279(48):49609-16.
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| REF 36 |
Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring. Biochem Biophys Res Commun. 2015 Dec 25;468(4):636-41.
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| REF 37 |
Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response. J Biol Chem. 2016 Jul 1;291(27):14373-84.
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| REF 38 |
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3565-3571.
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| REF 39 |
Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD). J Biol Chem. 2013 Mar 8;288(10):6998-7011.
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| REF 40 |
VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):552-559.
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| REF 41 |
Inhibition of p97-dependent protein degradation by Eeyarestatin I. J Biol Chem. 2008 Mar 21;283(12):7445-54.
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| REF 42 |
The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J Mol Biol. 2005 Dec 16;354(5):1021-7.
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| REF 43 |
Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease. FEBS Lett. 2016 Dec;590(23):4402-4413.
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| REF 44 |
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14132-8.
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| REF 45 |
VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol. 2007 Jun;36(6):706-14.
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| REF 46 |
The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival. J Biol Chem. 2006 May 19;281(20):14307-13.
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| REF 47 |
Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. J Cell Sci. 2006 Jun 1;119(Pt 11):2342-53.
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| REF 48 |
Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3. PLoS One. 2012;7(9):e43563.
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| REF 49 |
COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP. J Biol Chem. 2009 Dec 11;284(50):34944-53.
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| REF 50 |
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell. 2009 Oct 9;36(1):28-38.
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| REF 51 |
YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-B. Elife. 2017 Feb 28;6. pii: e22416.
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| REF 52 |
The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. J Biol Chem. 2011 Nov 4;286(44):38670-8.
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| REF 53 |
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet. 2006 Aug 15;15(16):2409-20.
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| REF 54 |
Structural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated Degradation. PLoS One. 2016 Sep 29;11(9):e0163394.
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| REF 55 |
Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions. Structure. 2016 Jan 5;24(1):140-147.
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| REF 56 |
Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins. FEBS J. 2009 Mar;276(5):1208-20.
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| REF 57 |
Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J. 2004 Feb 11;23(3):659-69.
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| REF 58 |
The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation. J Biol Chem. 2011 Feb 11;286(6):4892-901.
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| REF 59 |
Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. Nat Cell Biol. 2001 Aug;3(8):740-4.
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| REF 60 |
Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4. Biochem J. 2016 Sep 15;473(18):2863-80.
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| REF 61 |
VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. J Cell Biol. 2002 Dec 9;159(5):855-66.
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| REF 62 |
The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle. J Cell Biol. 2003 Jun 23;161(6):1067-79.
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| REF 63 |
The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins. PLoS One. 2011;6(9):e25061.
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| REF 64 |
Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect. BMC Cell Biol. 2014 Jul 31;15:31.
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| REF 65 |
UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation. Biochem Biophys Res Commun. 2009 May 1;382(2):303-8.
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| REF 66 |
Crystallization and preliminary X-ray crystallographic analysis of the N domain of p97/VCP in complex with the UBX domain of FAF1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):41-3.
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| REF 67 |
Crystallization and preliminary X-ray crystallographic analysis of the hexameric human p97/VCP ND1 fragment in complex with the UBX domain of human FAF1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1199-202.
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| REF 68 |
Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol Cell Biol. 2005 Mar;25(6):2511-24.
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| REF 69 |
Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha. J Biol Chem. 1998 Feb 6;273(6):3562-73.
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| REF 70 |
The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IB proteolysis. Mol Cell Biol. 2014 Feb;34(3):335-47.
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| REF 71 |
p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IB and the preceding liberation of RelA from ubiquitinated IB. J Cell Mol Med. 2016 Jan;20(1):58-70.
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| REF 72 |
Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase. Biochem Biophys Res Commun. 2017 Apr 22;486(1):94-100.
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| REF 73 |
Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation. J Biol Chem. 2015 Dec 11;290(50):29941-52.
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| REF 74 |
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. Nat Commun. 2013;4:1816.
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| REF 75 |
Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein. Biochem Biophys Res Commun. 2017 Dec 2;493(4):1384-1389.
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| REF 76 |
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res. 2010 Feb 5;9(2):1104-20.
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| REF 77 |
VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. J Biol Chem. 2009 May 1;284(18):12384-98.
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| REF 78 |
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal. 2009 Sep 8;2(87):ra51.
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| REF 79 |
Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex. Mol Biol Cell. 2015 Nov 1;26(21):3719-27.
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| REF 80 |
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol. 2009 Oct 19;187(2):201-17.
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