Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12646 Target Info
Target Name Valosin-containing protein p97 (VCP)
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Target Type Clinical trial Target
Gene Name VCP
Biochemical Class Acid anhydride hydrolase
UniProt ID
TERA_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Ras-related protein Rab-11B (RAB11B) Interacting Protein Interacting Protein Info
UniProt ID
RB11B_HUMAN 
Synonyms H.YPT3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Acyltransferases [+] 3 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase AMFR (AMFR) Interacting Protein Interacting Protein Info
UniProt ID
AMFR_HUMAN 
Synonyms GP78; RNF45
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [6]
6 Affinity Capture-Western [7]
7 Affinity Capture-Western [8]
8 Co-crystal Structure [7]
9 Protein-peptide [9]
10 Reconstituted Complex [10]
11 Yeast two hybrid [10]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [12]
Interacting Protein Name E3 ubiquitin-protein ligase RNF19A (RNF19A) Interacting Protein Interacting Protein Info
UniProt ID
RN19A_HUMAN 
Synonyms RNF19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Reconstituted Complex [14]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name UBX domain-containing protein 2B (UBXN2B) Interacting Protein Interacting Protein Info
UniProt ID
UBX2B_HUMAN 
Synonyms p37
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-MS [16]
3 Reconstituted Complex [17]
4 Yeast two hybrid [18]
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Target Name Caveolin 1 (CAV1) Literature-reported Target Interacting Protein Info
UniProt ID
CAV1_HUMAN 
Synonyms Caveolin-1; Caveolin1; Cav-1; CAV
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Co-localization [19]
3 Reconstituted Complex [20]
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [21]
Cullins [+] 1 Cullins +
Interacting Target Name Cullin-3 (CUL-3) Literature-reported Target Interacting Protein Info
UniProt ID
CUL3_HUMAN 
Synonyms KIAA0617; Cullin3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-Western [23]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Palmitoyl-protein thioesterase 1 (PPT1) Clinical trial Target Interacting Protein Info
UniProt ID
PPT1_HUMAN 
Synonyms PPT-1; PPT; Palmitoyl-protein hydrolase 1; CLN1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-Western [24]
FAM proteins [+] 1 FAM proteins +
Interacting Protein Name Protein FAM104A (FAM104A) Interacting Protein Interacting Protein Info
UniProt ID
F104A_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-MS [26]
3 Affinity Capture-MS [27]
4 Yeast two hybrid [18]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Adrenergic receptor beta-2 (ADRB2) Successful Target Interacting Protein Info
UniProt ID
ADRB2_HUMAN 
Synonyms Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Affinity Capture-Western [29]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Co-fractionation [31]
Hydrolysis-driven transporters [+] 3 Hydrolysis-driven transporters +
Interacting Protein Name Nuclear protein localization protein 4 homolog (NPLOC4) Interacting Protein Interacting Protein Info
UniProt ID
NPL4_HUMAN 
Synonyms NPL4
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-Luminescence [32]
2 Affinity Capture-MS [16]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [8]
5 Affinity Capture-Western [15]
6 Affinity Capture-Western [33]
7 Affinity Capture-Western [34]
8 Affinity Capture-Western [35]
9 Affinity Capture-Western [36]
10 Affinity Capture-Western [37]
11 Affinity Capture-Western [38]
12 Co-fractionation [35]
13 Reconstituted Complex [39]
14 Reconstituted Complex [40]
15 Yeast two hybrid [32]
Interacting Protein Name Derlin-1 (DERL1) Interacting Protein Interacting Protein Info
UniProt ID
DERL1_HUMAN 
Synonyms DER.1; DER1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Affinity Capture-Western [42]
3 Affinity Capture-Western [3]
4 Co-crystal Structure [43]
5 Protein-peptide [43]
6 Reconstituted Complex [44]
Interacting Target Name cAMP-dependent chloride channel (CFTR) Successful Target Interacting Protein Info
UniProt ID
CFTR_HUMAN 
Synonyms Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; cAMP-dependent chloride channel; cAMPdependent chloride channel; ATP-binding cassette sub-family C member 7; ATPbinding cassette subfamily C member 7; ABCC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [45]
2 Affinity Capture-Western [30]
Kinases [+] 1 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [46]
3 Affinity Capture-Western [1]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Acyl-CoA desaturase (SCD) Successful Target Interacting Protein Info
UniProt ID
ACOD_HUMAN 
Synonyms Stearoyl-coenzyme A (Delta9) desaturase; Stearoyl-CoA desaturase; Membrane-bound 9 desaturase; hSCD1; Fatty acid desaturase; DesA3; Des A3; Delta-9-stearoyl desaturase; Delta-9 desaturase; Delta(9)-desaturase; 9 stearoyl-desaturase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [47]
2 Co-fractionation [2]
Peptidases [+] 3 Peptidases +
Interacting Protein Name Ataxin-3 (ATXN3) Interacting Protein Interacting Protein Info
UniProt ID
ATX3_HUMAN 
Synonyms AT3; ATX3; JOS; MJD; MJD1; SCA3
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Luminescence [32]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [41]
4 Affinity Capture-Western [33]
5 Affinity Capture-Western [48]
6 Protein-peptide [9]
7 Yeast two hybrid [32]
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-Western [49]
3 Co-fractionation [49]
4 Reconstituted Complex [49]
Interacting Target Name Ubiquitin thioesterase OTU1 (YOD1) Literature-reported Target Interacting Protein Info
UniProt ID
OTU1_HUMAN 
Synonyms PRO0907; OTUD2; OTU domain-containing protein 2; HsHIN7; HIV-1-induced protease 7; HIN-7; HIN7; DUBA-8; DUBA8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [50]
2 Affinity Capture-Western [50]
3 Reconstituted Complex [50]
4 Yeast two hybrid [51]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Ankyrin repeat and zinc finger domain-containing protein 1 (ANKZF1) Interacting Protein Interacting Protein Info
UniProt ID
ANKZ1_HUMAN 
Synonyms ZNF744
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Protein-peptide [52]
Ubiquitin related proteins [+] 5 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1) Interacting Protein Interacting Protein Info
UniProt ID
UFD1_HUMAN 
Synonyms UFD1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-MS [26]
3 Affinity Capture-Western [41]
4 Affinity Capture-Western [53]
5 Affinity Capture-Western [3]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [15]
8 Affinity Capture-Western [33]
9 Affinity Capture-Western [34]
10 Affinity Capture-Western [35]
11 Affinity Capture-Western [36]
12 Affinity Capture-Western [37]
13 Affinity Capture-Western [38]
14 Affinity Capture-Western [54]
15 Co-crystal Structure [55]
16 Co-crystal Structure [54]
17 Co-fractionation [35]
18 Reconstituted Complex [55]
19 Reconstituted Complex [40]
20 Reconstituted Complex [54]
Interacting Target Name Synovial apoptosis inhibitor 1 (SYVN1) Literature-reported Target Interacting Protein Info
UniProt ID
SYVN1_HUMAN 
Synonyms RING-type E3 ubiquitin transferase synoviolin; KIAA1810; HRD1; E3 ubiquitin-protein ligase synoviolin; E3 ubiquitinprotein ligase synoviolin
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [42]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [33]
5 Co-crystal Structure [9]
6 Protein-peptide [9]
Interacting Protein Name Ubiquitin conjugation factor E4 B (UBE4B) Interacting Protein Interacting Protein Info
UniProt ID
UBE4B_HUMAN 
Synonyms E4; HDNB1; UBOX3; UFD2; UFD2A
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-MS [25]
3 Affinity Capture-Western [56]
4 Affinity Capture-Western [33]
5 Affinity Capture-Western [37]
6 Reconstituted Complex [57]
Interacting Protein Name UBX domain-containing protein 1 (UBXN1) Interacting Protein Interacting Protein Info
UniProt ID
UBXN1_HUMAN 
Synonyms 2B28; SAKS1; UBXD10
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [58]
3 Co-fractionation [58]
4 Yeast two hybrid [18]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Reconstituted Complex [59]
3 Reconstituted Complex [60]
Other proteins [+] 18 Other proteins +
Interacting Protein Name NSFL1 cofactor p47 (NSFL1C) Interacting Protein Interacting Protein Info
UniProt ID
NSF1C_HUMAN 
Synonyms P47; UBX1; UBXD10; UBXN2C; dJ776F14.1
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-Luminescence [32]
2 Affinity Capture-MS [15]
3 Affinity Capture-MS [26]
4 Affinity Capture-MS [27]
5 Affinity Capture-MS [16]
6 Affinity Capture-Western [33]
7 Affinity Capture-Western [34]
8 Affinity Capture-Western [37]
9 Affinity Capture-Western [61]
10 Reconstituted Complex [62]
11 Reconstituted Complex [10]
12 Reconstituted Complex [40]
13 Reconstituted Complex [17]
14 Yeast two hybrid [63]
15 Yeast two hybrid [18]
16 Yeast two hybrid [10]
17 Yeast two hybrid [32]
18 Yeast two hybrid [64]
Interacting Protein Name Tether containing UBX domain for GLUT4 (ASPSCR1) Interacting Protein Interacting Protein Info
UniProt ID
ASPC1_HUMAN 
Synonyms ASPCR1; ASPL; ASPS; RCC17; TUG; UBXD9; UBXN9
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-Luminescence [32]
2 Affinity Capture-MS [15]
3 Affinity Capture-MS [25]
4 Affinity Capture-MS [26]
5 Affinity Capture-MS [27]
6 Affinity Capture-MS [1]
7 Affinity Capture-MS [32]
8 Affinity Capture-MS [16]
9 Affinity Capture-Western [32]
10 Reconstituted Complex [32]
11 Yeast two hybrid [64]
12 Yeast two hybrid [18]
13 Yeast two hybrid [32]
Interacting Protein Name UBX domain-containing protein 6 (UBXN6) Interacting Protein Interacting Protein Info
UniProt ID
UBXN6_HUMAN 
Synonyms UBXD1; UBXDC2
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Luminescence [32]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [16]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [40]
6 Reconstituted Complex [52]
7 Reconstituted Complex [7]
8 Reconstituted Complex [65]
9 Yeast two hybrid [64]
10 Yeast two hybrid [32]
Interacting Protein Name FAS-associated factor 1 (FAF1) Interacting Protein Interacting Protein Info
UniProt ID
FAF1_HUMAN 
Synonyms HFAF1s; UBXD12; UBXN3A; hFAF1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-MS [1]
3 Co-crystal Structure [66]
4 Co-crystal Structure [67]
5 Reconstituted Complex [68]
6 Reconstituted Complex [39]
Interacting Protein Name NF-kappa-B inhibitor alpha (NFKBIA) Interacting Protein Interacting Protein Info
UniProt ID
IKBA_HUMAN 
Synonyms IKBA; MAD.3; NFKBI
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [69]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [70]
4 Affinity Capture-Western [71]
5 Reconstituted Complex [69]
Interacting Protein Name UBX domain-containing protein 2A (UBXN2A) Interacting Protein Interacting Protein Info
UniProt ID
UBX2A_HUMAN 
Synonyms UBXD4
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [32]
2 Affinity Capture-MS [15]
3 Affinity Capture-MS [26]
4 Affinity Capture-MS [16]
5 Yeast two hybrid [32]
Interacting Protein Name UBX domain-containing protein 7 (UBXN7) Interacting Protein Interacting Protein Info
UniProt ID
UBXN7_HUMAN 
Synonyms UBXD7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [15]
3 Co-crystal Structure [72]
4 Co-fractionation [15]
5 Reconstituted Complex [72]
Interacting Protein Name Selenoprotein S (SELENOS) Interacting Protein Interacting Protein Info
UniProt ID
SELS_HUMAN 
Synonyms ADO15; SBBI8; SELS; SEPS1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [36]
4 Reconstituted Complex [73]
Interacting Target Name Huntingtin (HTT) Clinical trial Target Interacting Protein Info
UniProt ID
HD_HUMAN 
Synonyms IT15; Huntington disease protein; Huntingtin; HD protein; HD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [74]
3 Reconstituted Complex [74]
Interacting Protein Name Ras GTPase-activating-like protein IQGAP1 (IQGAP1) Interacting Protein Interacting Protein Info
UniProt ID
IQGA1_HUMAN 
Synonyms HUMORFA01; SAR1; p195
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-Western [75]
3 Co-localization [75]
Interacting Protein Name Small VCP/p97-interacting protein (SVIP) Interacting Protein Interacting Protein Info
UniProt ID
SVIP_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [7]
3 Protein-peptide [9]
Interacting Target Name TAR DNA binding protein 43 (TARDBP) Clinical trial Target Interacting Protein Info
UniProt ID
TADBP_HUMAN 
Synonyms TDP-43; TDP43; TAR DNA-binding protein 43
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [76]
2 Affinity Capture-Western [77]
Interacting Target Name Vascular cell adhesion protein 1 (VCAM1) Literature-reported Target Interacting Protein Info
UniProt ID
VCAM1_HUMAN 
Synonyms VCAM-1; V-CAM 1; Vascular cell adhesion protein 1; Vascular cell adhesion molecule 1; INCAM-100; CD106 antigen; CD106
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [78]
2 Affinity Capture-Western [79]
Interacting Protein Name FAS-associated factor 2 (FAF2) Interacting Protein Interacting Protein Info
UniProt ID
FAF2_HUMAN 
Synonyms ETEA; UBXD8; UBXN3B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Yeast two hybrid [64]
Interacting Protein Name Tubulin beta-2 chain (TUBB2) Interacting Protein Interacting Protein Info
UniProt ID
TBB4B_HUMAN 
Synonyms Beta2; TUBB2; TUBB2C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Co-fractionation [2]
Interacting Protein Name Tubulin beta chain (TUBB) Interacting Protein Interacting Protein Info
UniProt ID
TBB5_HUMAN 
Synonyms CDCBM6; M40; OK/SW.cl.56; TUBB1; TUBB5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Co-fractionation [2]
Interacting Protein Name Ubiquilin-1 (UBQLN1) Interacting Protein Interacting Protein Info
UniProt ID
UBQL1_HUMAN 
Synonyms DA41; DSK2; PLIC.1; UBQN; XDRP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [80]
Interacting Protein Name UBX domain-containing protein 4 (UBXN4) Interacting Protein Interacting Protein Info
UniProt ID
UBXN4_HUMAN 
Synonyms UBXD2; UBXDC1; erasin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [80]
2 Yeast two hybrid [64]
References  Top
REF 1 VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. PLoS One. 2013;8(1):e55724.
REF 2 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 3 Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. J Biol Chem. 2007 Nov 23;282(47):33908-14.
REF 4 AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem. 2004 Oct 29;279(44):45676-84.
REF 5 Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. PLoS One. 2010 Jan 26;5(1):e8905.
REF 6 Vectors for co-expression of an unrestricted number of proteins. Nucleic Acids Res. 2007;35(6):e43.
REF 7 The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. J Biol Chem. 2011 Nov 4;286(44):38679-90.
REF 8 A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization. Int J Biochem Cell Biol. 2013 Apr;45(4):773-82.
REF 9 Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP. Biochim Biophys Acta. 2013 Dec;1834(12):2672-8.
REF 10 Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics. 2006 Feb;5(2):234-44.
REF 11 mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response. Mol Cell Biol. 2018 Jan 29;38(4). pii: e00364-17.
REF 12 VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells. DNA Cell Biol. 2000 May;19(5):253-63.
REF 13 Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin. J Biol Chem. 2006 Apr 28;281(17):11610-7.
REF 14 Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. J Biol Chem. 2004 Dec 3;279(49):51376-85.
REF 15 UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell. 2008 Sep 5;134(5):804-16.
REF 16 Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Nat Cell Biol. 2015 Oct;17(10):1356-69.
REF 17 Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1705-14.
REF 18 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 19 Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. J Biol Chem. 2013 Mar 8;288(10):7363-72.
REF 20 Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. J Biol Chem. 2013 Nov 15;288(46):33462-9.
REF 21 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 22 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 23 NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1.
REF 24 Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. J Proteomics. 2015 Jun 18;123:42-53.
REF 25 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 26 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 27 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 28 Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol. 2013 Aug;27(8):1245-66.
REF 29 VCP/p97 regulates 2AR quality control during receptor biosynthesis. Cell Signal. 2017 Jan;30:50-58.
REF 30 Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J Biol Chem. 2006 Jun 23;281(25):17369-78.
REF 31 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 32 Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun. 2016 Oct 20;7:13047.
REF 33 Imbalances in p97 co-factor interactions in human proteinopathy. EMBO Rep. 2010 Jun;11(6):479-85.
REF 34 ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif. J Biol Chem. 2005 Dec 16;280(50):41332-41.
REF 35 The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem. 2004 Nov 26;279(48):49609-16.
REF 36 Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring. Biochem Biophys Res Commun. 2015 Dec 25;468(4):636-41.
REF 37 Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response. J Biol Chem. 2016 Jul 1;291(27):14373-84.
REF 38 p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3565-3571.
REF 39 Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD). J Biol Chem. 2013 Mar 8;288(10):6998-7011.
REF 40 VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):552-559.
REF 41 Inhibition of p97-dependent protein degradation by Eeyarestatin I. J Biol Chem. 2008 Mar 21;283(12):7445-54.
REF 42 The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J Mol Biol. 2005 Dec 16;354(5):1021-7.
REF 43 Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease. FEBS Lett. 2016 Dec;590(23):4402-4413.
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REF 50 The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell. 2009 Oct 9;36(1):28-38.
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REF 61 VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. J Cell Biol. 2002 Dec 9;159(5):855-66.
REF 62 The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle. J Cell Biol. 2003 Jun 23;161(6):1067-79.
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REF 68 Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol Cell Biol. 2005 Mar;25(6):2511-24.
REF 69 Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha. J Biol Chem. 1998 Feb 6;273(6):3562-73.
REF 70 The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IB proteolysis. Mol Cell Biol. 2014 Feb;34(3):335-47.
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REF 72 Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase. Biochem Biophys Res Commun. 2017 Apr 22;486(1):94-100.
REF 73 Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation. J Biol Chem. 2015 Dec 11;290(50):29941-52.
REF 74 A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. Nat Commun. 2013;4:1816.
REF 75 Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein. Biochem Biophys Res Commun. 2017 Dec 2;493(4):1384-1389.
REF 76 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res. 2010 Feb 5;9(2):1104-20.
REF 77 VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. J Biol Chem. 2009 May 1;284(18):12384-98.
REF 78 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal. 2009 Sep 8;2(87):ra51.
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REF 80 Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol. 2009 Oct 19;187(2):201-17.

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