Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Huntingtin (HTT) | Clinical trial | Target Info | ||
| UniProt ID | HD_HUMAN | ||||
| Gene Name | HTT | ||||
| Gene ID | 3064 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Valosin-containing protein p97 (VCP) | Target Info | PPI Info | [1] | |
| CREB-binding protein (CREBBP) | Target Info | PPI Info | [2] | ||
| Huntingtin (HTT) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | Lysine N-methyltransferase 3A (SETD2) | Target Info | PPI Info | [4] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. PLoS One. 2013;8(1):e55724. | ||||
| REF 2 | Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci. 2005 Dec;30(4):560-71. | ||||
| REF 3 | Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol Cell. 2004 Jul 2;15(1):95-105. | ||||
| REF 4 | Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin. Structure. 2014 Mar 4;22(3):378-86. | ||||
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