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| Target General Information |
Top |
| Target ID |
T73551 |
Target Info
|
| Target Name |
Lysine N-methyltransferase 3A (SETD2) |
| Synonyms |
p231HBP; hSET2; SET2; SET domain-containing protein 2; Protein-lysine N-methyltransferase SETD2; KMT3A; KIAA1732; Huntingtin-interacting protein B; Huntingtin-interacting protein 1; Huntingtin yeast partner B; Histone-lysine N-methyltransferase SETD2; HYPB; HSPC069; HIP-1; HIF1 |
| Target Type |
Literature-reported Target |
| Gene Name |
SETD2 |
| Biochemical Class |
Methyltransferase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Histones |
[+] 1 Histones |
+ |
| Interacting Protein Name |
Histone H3.1 (H31) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
H3/A; H3FA |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Biochemical Activity |
[1] |
| 2 |
Protein-peptide |
[2] |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Target Name |
Huntingtin (HTT) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
IT15; Huntington disease protein; Huntingtin; HD protein; HD |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Co-crystal Structure |
[3] |
| 2 |
Co-localization |
[3] |
| 3 |
Yeast two hybrid |
[4] |
| References |
Top |
| REF 1 |
Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem. 2005 Oct 21;280(42):35261-71.
|
| REF 2 |
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining P... J Biol Chem. 2016 Sep 30;291(40):21283-21295.
|
| REF 3 |
Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin. Structure. 2014 Mar 4;22(3):378-86.
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| REF 4 |
Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet. 1998 Sep;7(9):1463-74.
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