Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T87376 Target Info
Target Name Renal carcinoma antigen NY-REN-54 (UBE3A)
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Target Type Literature-reported Target
Gene Name UBE3A
Biochemical Class Acyltransferase
UniProt ID
UBE3A_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 6 Acid anhydride hydrolases +
Interacting Protein Name Proteasome 26S subunit ATPase 1 (PSMC1) Interacting Protein Interacting Protein Info
UniProt ID
PRS4_HUMAN 
Synonyms P26S4; S4; p56
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Biochemical Activity [5]
Interacting Protein Name Proteasome 26S subunit ATPase 6 (PSMC6) Interacting Protein Interacting Protein Info
UniProt ID
PRS10_HUMAN 
Synonyms CADP44; HEL.S.73; P44; SUG2; p42
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit ATPase 4 (PSMC4) Interacting Protein Interacting Protein Info
UniProt ID
PRS6B_HUMAN 
Synonyms MIP224; RPT3; S6; TBP.7; TBP7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit ATPase 2 (PSMC2) Interacting Protein Interacting Protein Info
UniProt ID
PRS7_HUMAN 
Synonyms MSS1; Nbla10058; S7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit ATPase 5 (PSMC5) Interacting Protein Interacting Protein Info
UniProt ID
PRS8_HUMAN 
Synonyms S8; SUG.1; SUG1; TBP10; TRIP1; p45; p45/SUG
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Actins [+] 1 Actins +
Interacting Protein Name Beta-actin-like protein 2 (ACTBL2) Interacting Protein Interacting Protein Info
UniProt ID
ACTBL_HUMAN 
Synonyms ACT
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [6]
Acyltransferases [+] 4 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase HERC2 (HERC2) Interacting Protein Interacting Protein Info
UniProt ID
HERC2_HUMAN 
Synonyms D15F37S1; MRT38; SHEP1; jdf2; p528
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [1]
5 Affinity Capture-Western [3]
6 Affinity Capture-Western [7]
7 Co-fractionation [1]
8 Co-purification [7]
Interacting Protein Name UV excision repair protein RAD23 homolog A (RAD23A) Interacting Protein Interacting Protein Info
UniProt ID
RD23A_HUMAN 
Synonyms HHR23A; HR23A
Evidence Score (E-score) 8 Experimental Evidences +
1 Biochemical Activity [8]
2 Biochemical Activity [9]
3 Biochemical Activity [10]
4 Biochemical Activity [11]
5 Biochemical Activity [12]
6 Biochemical Activity [13]
7 Yeast two hybrid [2]
8 Yeast two hybrid [12]
Interacting Protein Name E3 ubiquitin-protein ligase RING2 (RNF2) Interacting Protein Interacting Protein Info
UniProt ID
RING2_HUMAN 
Synonyms BAP.1; BAP1; DING; HIPI3; RING1B; RING2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Biochemical Activity [15]
3 Biochemical Activity [11]
4 Reconstituted Complex [15]
Interacting Protein Name UV excision repair protein RAD23 homolog B (RAD23B) Interacting Protein Interacting Protein Info
UniProt ID
RD23B_HUMAN 
Synonyms HHR23B; HR23B; P58
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [9]
3 Yeast two hybrid [2]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Co-localization [16]
3 Reconstituted Complex [17]
Intermediate filaments [+] 1 Intermediate filaments +
Interacting Protein Name Cytokeratin-6B (KRT6B) Interacting Protein Interacting Protein Info
UniProt ID
K2C6B_HUMAN 
Synonyms CK.6B; CK6B; K6B; KRTL1; PC2; PC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [6]
Isomerases [+] 2 Isomerases +
Interacting Protein Name Enoyl-CoA hydratase 1 (ECH1) Interacting Protein Interacting Protein Info
UniProt ID
ECH1_HUMAN 
Synonyms HPXEL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Enoyl-CoA delta isomerase 2 (ECI2) Interacting Protein Interacting Protein Info
UniProt ID
ECI2_HUMAN 
Synonyms ACBD2; DRS.1; DRS1; HCA88; PECI; dJ1013A10.3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Kinases [+] 1 Kinases +
Interacting Protein Name Mitogen-activated protein kinase 6 (MAPK6) Interacting Protein Interacting Protein Info
UniProt ID
MK06_HUMAN 
Synonyms ERK3; HsT17250; PRKM6; p97MAPK
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Co-fractionation [1]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Biochemical Activity [19]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) Interacting Protein Interacting Protein Info
UniProt ID
HIF1N_HUMAN 
Synonyms FIH1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Co-fractionation [1]
Peptidases [+] 18 Peptidases +
Interacting Target Name Proteasome beta-5 (PS beta-5) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB5_HUMAN 
Synonyms Proteasome subunit X; Proteasome subunit MB1; Proteasome subunit beta type-5; Proteasome epsilon chain; Proteasome chain 6; Multicatalytic endopeptidase complex epsilon chain; MB1; Macropain epsilon chain; LMPX
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Target Name Proteasome beta-2 (PS beta-2) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB7_HUMAN 
Synonyms Proteasome subunit Z; Proteasome subunit beta type-7; Multicatalytic endopeptidase complex chain Z; Macropain chain Z
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Target Name Proteasome beta-1 (PS beta-1) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB6_HUMAN 
Synonyms Proteasome subunit Y; Proteasome subunit beta type-6; Proteasome delta chain; Multicatalytic endopeptidase complex delta chain; Macropain delta chain; LMPY
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Target Name Ubiquitin C-terminal hydrolase UCH37 (UCHL5) Patented-recorded Target Interacting Protein Info
UniProt ID
UCHL5_HUMAN 
Synonyms UCH-L5; UCH37; Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI-70; AD-019
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Biochemical Activity [5]
Interacting Protein Name Proteasome subunit alpha type-1 (PSMA1) Interacting Protein Interacting Protein Info
UniProt ID
PSA1_HUMAN 
Synonyms HC2; HEL.S.275; NU; PROS30
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit alpha type-2 (PSMA2) Interacting Protein Interacting Protein Info
UniProt ID
PSA2_HUMAN 
Synonyms HC3; MU; PMSA2; PSC2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit alpha type-3 (PSMA3) Interacting Protein Interacting Protein Info
UniProt ID
PSA3_HUMAN 
Synonyms HC8; PSC3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit alpha type-4 (PSMA4) Interacting Protein Interacting Protein Info
UniProt ID
PSA4_HUMAN 
Synonyms HC9; HsT17706; PSC9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit alpha type-5 (PSMA5) Interacting Protein Interacting Protein Info
UniProt ID
PSA5_HUMAN 
Synonyms PSC5; ZETA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit alpha type-6 (PSMA6) Interacting Protein Interacting Protein Info
UniProt ID
PSA6_HUMAN 
Synonyms IOTA; PROS27; p27K
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit alpha type-7 (PSMA7) Interacting Protein Interacting Protein Info
UniProt ID
PSA7_HUMAN 
Synonyms C6; HSPC; RC6.1; XAPC7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit beta type-1 (PSMB1) Interacting Protein Interacting Protein Info
UniProt ID
PSB1_HUMAN 
Synonyms HC5; PMSB1; PSC5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit beta type-2 (PSMB2) Interacting Protein Interacting Protein Info
UniProt ID
PSB2_HUMAN 
Synonyms HC7.I
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit beta type-3 (PSMB3) Interacting Protein Interacting Protein Info
UniProt ID
PSB3_HUMAN 
Synonyms HC10.II
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome subunit beta type-4 (PSMB4) Interacting Protein Interacting Protein Info
UniProt ID
PSB4_HUMAN 
Synonyms HN3; HsN3; PROS.26; PROS26
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 14 (PSMD14) Interacting Protein Interacting Protein Info
UniProt ID
PSDE_HUMAN 
Synonyms PAD1; POH1; RPN11
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 7 (PSMD7) Interacting Protein Interacting Protein Info
UniProt ID
PSMD7_HUMAN 
Synonyms MOV34; P40; Rpn8; S12
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Target Name Ubiquitin carboxyl-terminal hydrolase 14 (USP14) Preclinical Target Interacting Protein Info
UniProt ID
UBP14_HUMAN 
Synonyms Ubiquitin-specific-processing protease 14; Ubiquitin thioesterase 14; TGT; Deubiquitinating enzyme 14
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Co-fractionation [20]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [22]
3 Biochemical Activity [23]
4 Biochemical Activity [24]
5 Biochemical Activity [13]
6 Biochemical Activity [21]
7 Biochemical Activity [25]
8 Biochemical Activity [26]
9 Biochemical Activity [27]
10 Co-crystal Structure [28]
11 Reconstituted Complex [17]
12 Reconstituted Complex [21]
13 Reconstituted Complex [29]
Proteasome components [+] 9 Proteasome components +
Interacting Protein Name Proteasome 26S subunit non-ATPase 4 (PSMD4) Interacting Protein Interacting Protein Info
UniProt ID
PSMD4_HUMAN 
Synonyms AF; AF.1; ASF; MCB1; Rpn10; S5A; pUB.R5
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [3]
5 Biochemical Activity [30]
6 Biochemical Activity [31]
7 Biochemical Activity [5]
8 Co-fractionation [1]
9 Co-fractionation [2]
10 Yeast two hybrid [2]
Interacting Protein Name Tumor necrosis factor type 1 receptor-associated protein 2 (PSMD2) Interacting Protein Interacting Protein Info
UniProt ID
PSMD2_HUMAN 
Synonyms P97; RPN1; S2; TRAP2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Biochemical Activity [32]
Interacting Protein Name Proteasome 26S subunit non-ATPase 3 (PSMD3) Interacting Protein Interacting Protein Info
UniProt ID
PSMD3_HUMAN 
Synonyms P58; RPN3; S3; TSTA2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [33]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 11 (PSMD11) Interacting Protein Interacting Protein Info
UniProt ID
PSD11_HUMAN 
Synonyms Rpn6; S9; p44.5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 12 (PSMD12) Interacting Protein Interacting Protein Info
UniProt ID
PSD12_HUMAN 
Synonyms Rpn5; p55
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 13 (PSMD13) Interacting Protein Interacting Protein Info
UniProt ID
PSD13_HUMAN 
Synonyms HSPC027; Rpn9; S11; p40.5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 1 (PSMD1) Interacting Protein Interacting Protein Info
UniProt ID
PSMD1_HUMAN 
Synonyms P112; Rpn2; S1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 6 (PSMD6) Interacting Protein Interacting Protein Info
UniProt ID
PSMD6_HUMAN 
Synonyms Rpn7; S10; SGA.113M; p42A; p44S10
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit non-ATPase 8 (PSMD8) Interacting Protein Interacting Protein Info
UniProt ID
PSMD8_HUMAN 
Synonyms HEL.S.91n; HIP6; HYPF; Nin1p; Rpn12; S14; p31
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Ubiquitin related proteins [+] 3 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) Interacting Protein Interacting Protein Info
UniProt ID
UB2L3_HUMAN 
Synonyms E2.F1; L.UBC; UBCH7; UbcM4
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [35]
3 Biochemical Activity [36]
4 Co-crystal Structure [36]
5 Fluorescence Resonance Energy Transfer [37]
6 Reconstituted Complex [36]
7 Reconstituted Complex [38]
8 Reconstituted Complex [39]
9 Reconstituted Complex [40]
10 Reconstituted Complex [9]
11 Reconstituted Complex [10]
12 Reconstituted Complex [11]
13 Reconstituted Complex [12]
14 Reconstituted Complex [15]
15 Reconstituted Complex [21]
16 Reconstituted Complex [25]
17 Reconstituted Complex [41]
18 Reconstituted Complex [37]
19 Reconstituted Complex [42]
20 Reconstituted Complex [43]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 8 Experimental Evidences +
1 Reconstituted Complex [44]
2 Reconstituted Complex [45]
3 Reconstituted Complex [38]
4 Reconstituted Complex [5]
5 Reconstituted Complex [11]
6 Reconstituted Complex [27]
7 Reconstituted Complex [46]
8 Yeast two hybrid [44]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 E1 (UBE2E1) Interacting Protein Interacting Protein Info
UniProt ID
UB2E1_HUMAN 
Synonyms UBCH6
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [41]
2 Reconstituted Complex [10]
3 Yeast two hybrid [10]
Other proteins [+] 6 Other proteins +
Interacting Protein Name Neuralized-like protein 4 (NEURL4) Interacting Protein Interacting Protein Info
UniProt ID
NEUL4_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [1]
5 Co-fractionation [1]
Interacting Protein Name Ubiquilin-2 (UBQLN2) Interacting Protein Interacting Protein Info
UniProt ID
UBQL2_HUMAN 
Synonyms ALS15; CHAP1; DSK2; N4BP4; PLIC2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [47]
2 Co-fractionation [47]
3 Yeast two hybrid [47]
4 Yeast two hybrid [2]
Interacting Protein Name Calmodulin-1 (CALM1) Interacting Protein Interacting Protein Info
UniProt ID
CALM1_HUMAN 
Synonyms CALML2; CAMI; CPVT4; DD132; PHKD; caM
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [33]
2 Affinity Capture-MS [1]
3 Reconstituted Complex [6]
Interacting Protein Name Protein scribble homolog (SCRIB) Interacting Protein Interacting Protein Info
UniProt ID
SCRIB_HUMAN 
Synonyms CRIB1; SCRB1; SCRIB1; Vartul
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [21]
2 Reconstituted Complex [48]
3 Reconstituted Complex [21]
Interacting Protein Name Proteasome activator complex subunit 4 (PSME4) Interacting Protein Interacting Protein Info
UniProt ID
PSME4_HUMAN 
Synonyms PA200
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
Interacting Protein Name Ubiquilin-1 (UBQLN1) Interacting Protein Interacting Protein Info
UniProt ID
UBQL1_HUMAN 
Synonyms DA41; DSK2; PLIC.1; UBQN; XDRP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Yeast two hybrid [47]
2 Yeast two hybrid [2]
References  Top
REF 1 Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012 Aug;32(15):3095-106.
REF 2 Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol. 2018 Mar 30;430(7):1024-1050.
REF 3 Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome. J Biol Chem. 2018 Nov 23;293(47):18387-18399.
REF 4 Insights into the ubiquitin-proteasome system of human embryonic stem cells. Sci Rep. 2018 Mar 6;8(1):4092.
REF 5 Autoregulation of the 26S proteasome by in situ ubiquitination. Mol Biol Cell. 2014 Jun 15;25(12):1824-35.
REF 6 Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation. Oncotarget. 2016 Feb 16;7(7):7640-56.
REF 7 Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2. J Biol Chem. 2011 Jun 3;286(22):19410-6.
REF 8 Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J Biol Chem. 2007 Jun 15;282(24):17375-86.
REF 9 Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination. J Biol Chem. 1999 Jun 25;274(26):18785-92.
REF 10 Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. J Biol Chem. 1997 May 23;272(21):13548-54.
REF 11 Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9872-7.
REF 12 Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. J Biol Chem. 2004 Sep 24;279(39):41208-17.
REF 13 Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer. Nat Commun. 2017 Dec 20;8(1):2232.
REF 14 RYBP modulates stability and function of Ring1B through targeting UBE3A. FASEB J. 2019 Jan;33(1):683-695.
REF 15 Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6788-93.
REF 16 The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins. J Biol Chem. 2009 Apr 17;284(16):10537-45.
REF 17 E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. Neurobiol Aging. 2013 Apr;34(4):1310.e11-23.
REF 18 Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol Endocrinol. 2006 Mar;20(3):544-59.
REF 19 Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity. Nucleic Acids Res. 2017 Feb 28;45(4):1793-1804.
REF 20 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 21 Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol. 2000 Nov;20(21):8244-53.
REF 22 Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8797-801.
REF 23 Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. J Mol Biol. 2004 Mar 12;337(1):129-45.
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