Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T49031 Target Info
Target Name Proteasome beta-5 (PS beta-5)
Synonyms Proteasome subunit beta type-5; Proteasome subunit X; Proteasome subunit MB1; Proteasome epsilon chain; Proteasome chain 6; Multicatalytic endopeptidase complex epsilon chain; Macropain epsilon chain; MB1; LMPX
Target Type Patented-recorded Target
Gene Name PSMB5
Biochemical Class Peptidase
UniProt ID
PSB5_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Renal carcinoma antigen NY-REN-54 (UBE3A) Literature-reported Target Interacting Protein Info
UniProt ID
UBE3A_HUMAN 
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Peptidases [+] 7 Peptidases +
Interacting Target Name Proteasome beta-2 (PS beta-2) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB7_HUMAN 
Synonyms Proteasome subunit Z; Proteasome subunit beta type-7; Multicatalytic endopeptidase complex chain Z; Macropain chain Z
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [2]
2 Yeast two hybrid [3]
3 Yeast two hybrid [4]
Interacting Target Name Proteasome beta-1 (PS beta-1) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB6_HUMAN 
Synonyms Proteasome subunit Y; Proteasome subunit beta type-6; Proteasome delta chain; Multicatalytic endopeptidase complex delta chain; Macropain delta chain; LMPY
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [5]
2 Co-fractionation [2]
3 Yeast two hybrid [4]
Interacting Protein Name Proteasome subunit alpha type-3 (PSMA3) Interacting Protein Interacting Protein Info
UniProt ID
PSA3_HUMAN 
Synonyms HC8; PSC3
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [5]
2 Yeast two hybrid [3]
3 Yeast two hybrid [4]
Interacting Protein Name Proteasome subunit beta type-3 (PSMB3) Interacting Protein Interacting Protein Info
UniProt ID
PSB3_HUMAN 
Synonyms HC10.II
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-fractionation [5]
2 Yeast two hybrid [3]
3 Yeast two hybrid [4]
Interacting Target Name Proteasome beta-9 (PS beta-9) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB9_HUMAN 
Synonyms RING12; Really interesting new gene 12 protein; PSMB6i; Proteasome subunit beta-1i; Proteasome subunit beta type-9; Proteasome chain 7; Multicatalytic endopeptidase complex chain 7; Macropain chain 7; Low molecular mass protein 2; LMP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
Interacting Target Name Ubiquitin C-terminal hydrolase UCH37 (UCHL5) Patented-recorded Target Interacting Protein Info
UniProt ID
UCHL5_HUMAN 
Synonyms UCH-L5; UCH37; Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI-70; AD-019
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Co-fractionation [5]
Interacting Protein Name Proteasome subunit alpha type-2 (PSMA2) Interacting Protein Interacting Protein Info
UniProt ID
PSA2_HUMAN 
Synonyms HC3; MU; PMSA2; PSC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Yeast two hybrid [3]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Proteasome maturation protein (POMP) Interacting Protein Interacting Protein Info
UniProt ID
POMP_HUMAN 
Synonyms C13orf12; PNAS.110; UMP1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Yeast two hybrid [3]
4 Yeast two hybrid [4]
5 Yeast two hybrid [10]
References  Top
REF 1 Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012 Aug;32(15):3095-106.
REF 2 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 3 Protein-protein interactions among human 20S proteasome subunits and proteassemblin. Biochem Biophys Res Commun. 2004 Feb 6;314(2):523-8.
REF 4 The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO Rep. 2007 Dec;8(12):1170-5.
REF 5 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 6 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 7 Novel propeptide function in 20 S proteasome assembly influences beta subunit composition. J Biol Chem. 2000 Aug 4;275(31):24156-62.
REF 8 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 9 A novel testis-specific GTPase serves as a link to proteasome biogenesis: functional characterization of RhoS/RSA-14-44 in spermatogenesis. Mol Biol Cell. 2010 Dec;21(24):4312-24.
REF 10 IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9241-6.

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