Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T87109 Target Info
Target Name Casein kinase I delta (CSNK1D)
Synonyms Tau-protein kinase CSNK1D; HCKID; Casein kinase I isoform delta; CKId; CKI-delta
Target Type Preclinical Target
Gene Name CSNK1D
Biochemical Class Kinase
UniProt ID
KC1D_HUMAN 
Target Interacting Proteins  Top
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
4 Co-localization [4]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [6]
3 Biochemical Activity [3]
References  Top
REF 1 PML enhances the regulation of p53 by CK1 in response to DNA damage. Oncogene. 2008 Jun 12;27(26):3653-61.
REF 2 Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett. 2006 Nov 27;580(27):6477-84.
REF 3 Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation. J Biol Chem. 2006 Sep 29;281(39):28575-83.
REF 4 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 5 DNA damage-induced activation of ATM promotes -TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012 Sep;3(9):1026-35.
REF 6 Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 9;18(2):147-59.

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