| References |
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| REF 1 |
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol. 2009 Jan;11(1):85-91.
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| REF 2 |
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. Nat Cell Biol. 2008 Jul;10(7):812-24.
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| REF 3 |
Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1. Cancer Lett. 2009 Jul 8;279(2):177-84.
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| REF 4 |
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J. 2010 Nov 17;29(22):3750-61.
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| REF 5 |
The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep. 2016 Jun 16;6:28241.
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| REF 6 |
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol. 2002 Jan;4(1):1-10.
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| REF 7 |
MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell. 2007 Mar 9;25(5):739-50.
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| REF 8 |
XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15532-7.
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| REF 9 |
Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation. FEBS Lett. 2005 Jun 6;579(14):3001-8.
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| REF 10 |
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004 Apr 1;18(7):816-29.
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| REF 11 |
The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol Biol Cell. 2005 Oct;16(10):4705-13.
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| REF 12 |
HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations. FEBS Lett. 2005 Oct 24;579(25):5473-80.
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| REF 13 |
Control of nuclear HIPK2 localization and function by a SUMO interaction motif. Biochim Biophys Acta. 2011 Feb;1813(2):283-97.
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| REF 14 |
PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage. Oncogene. 2009 Feb 5;28(5):698-708.
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| REF 15 |
SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell. 2010 Feb 26;37(4):503-15.
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| REF 16 |
Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53. Exp Cell Res. 2011 Apr 15;317(7):1060-70.
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