Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T89859 Target Info
Target Name Orphan nuclear receptor SHP (NR0B2)
Synonyms Small heterodimer partner; Short heterodimer partner; SHP; Nuclear receptor subfamily 0 group B member 2
Target Type Literature-reported Target
Gene Name NR0B2
Biochemical Class Nuclear hormone receptor
UniProt ID
NR0B2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Probable global transcription activator SNF2L2 (SMARCA2) Interacting Protein Interacting Protein Info
UniProt ID
SMCA2_HUMAN 
Synonyms BAF190; BRM; NCBRS; SNF2; SNF2L2; SNF2LA; SWI2; Sth1p; hBRM; hSNF2a
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [1]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [4]
4 Reconstituted Complex [3]
5 Reconstituted Complex [4]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [3]
3 Reconstituted Complex [4]
Nuclear hormone receptors [+] 7 Nuclear hormone receptors +
Interacting Target Name Liver receptor homolog-1 (NR5A2) Literature-reported Target Interacting Protein Info
UniProt ID
NR5A2_HUMAN 
Synonyms Nuclear receptor subfamily 5 group A member 2; LRH-1; LRH1; Liver receptor homolog 1; Hepatocytic transcription factor; hB1F; FTF; CYP7A promoter-binding factor; CYP7A promoterbinding factor; CPF; B1F; B1-binding factor; B1binding factor; Alpha-1-fetoprotein transcription factor; Alpha1fetoprotein transcription factor
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [5]
3 Yeast two hybrid [6]
4 Yeast two hybrid [7]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Protein-peptide [9]
3 Reconstituted Complex [8]
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [6]
2 Yeast two hybrid [10]
3 Yeast two hybrid [11]
Interacting Target Name Retinoic acid receptor alpha (RARA) Clinical trial Target Interacting Protein Info
UniProt ID
RARA_HUMAN 
Synonyms RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [12]
2 Reconstituted Complex [13]
3 Yeast two hybrid [13]
Interacting Target Name Oxysterols receptor LXR-alpha (NR1H3) Patented-recorded Target Interacting Protein Info
UniProt ID
NR1H3_HUMAN 
Synonyms Nuclear receptor subfamily 1 group H member 3; Nuclear receptor LXRalpha; Nuclear orphan receptor LXR-alpha; LXRalpha; LXRA; Liver X receptor alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [6]
3 Co-localization [14]
Interacting Target Name Hepatocyte nuclear factor 4-alpha (HNF4A) Literature-reported Target Interacting Protein Info
UniProt ID
HNF4A_HUMAN 
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF-14; TCF14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF-4-alpha; HNF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [15]
2 Yeast two hybrid [16]
Interacting Target Name Estrogen-related receptor-gamma (ESRRG) Literature-reported Target Interacting Protein Info
UniProt ID
ERR3_HUMAN 
Synonyms Nuclear receptor subfamily 3 group B member 3; NR3B3; KIAA0832; Estrogen-related receptor gamma; Estrogen receptor-related protein 3; ERRG2; ERR3; ERR gamma-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [15]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Affinity Capture-Western [19]
3 Reconstituted Complex [19]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Co-localization [20]
References  Top
REF 1 Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP. Mol Cell Biol. 2004 Sep;24(17):7707-19.
REF 2 Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. Mol Cell Biol. 2011 Apr;31(7):1540-50.
REF 3 SHP represses transcriptional activity via recruitment of histone deacetylases. Biochemistry. 2005 Apr 26;44(16):6312-20.
REF 4 Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15665-70.
REF 5 Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1. Mol Endocrinol. 2004 May;18(5):1082-95.
REF 6 The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol Endocrinol. 2002 Sep;16(9):2065-76.
REF 7 Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem. 2002 Jan 25;277(4):2463-7.
REF 8 Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. J Biol Chem. 2002 Jan 11;277(2):1586-92.
REF 9 Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics. 2009 Oct;8(10):2212-26.
REF 10 The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol. 2000 Jan;20(1):187-95.
REF 11 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 12 An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9.
REF 13 Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner). Mol Endocrinol. 1998 Oct;12(10):1551-7.
REF 14 Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes. Sci Signal. 2016 Aug 2;9(439):ra78.
REF 15 Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. J Biol Chem. 2010 Aug 6;285(32):24871-81.
REF 16 Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. J Biol Chem. 2001 Nov 9;276(45):41690-9.
REF 17 Nuclear receptor SHP inhibition of Dnmt1 expression via ERR. FEBS Lett. 2011 May 6;585(9):1269-75.
REF 18 An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability. FEBS Lett. 2012 Apr 24;586(8):1135-40.
REF 19 Cross-regulation of protein stability by p53 and nuclear receptor SHP. PLoS One. 2012;7(6):e39789.
REF 20 Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition. Biochem Biophys Res Commun. 2012 Jan 13;417(2):744-6.

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