Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T32348 Target Info
Target Name Early growth response protein 1 (EGR-1)
Synonyms Zinc finger protein Krox24; Zinc finger protein Krox-24; Zinc finger protein 225; ZNF225; Transcription factor Zif268; Transcription factor ETR103; Nerve growth factorinduced protein A; Nerve growth factor-induced protein A; NGFIA; NGFI-A; KROX24; AT225
Target Type Clinical trial Target
Gene Name EGR1
Biochemical Class EGR C2H2-type zinc-finger
UniProt ID
EGR1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Pore-forming toxins [+] 1 Pore-forming toxins +
Transcription regulators [+] 1 Transcription regulators +
References  Top
REF 1 Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell. 2004 Jul 2;15(1):83-94.
REF 2 cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). Biochem J. 1998 Nov 15;336 ( Pt 1):183-9.
REF 3 Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):536-45.
REF 4 Physical interaction between p53 and primary response gene Egr-1. Int J Oncol. 2001 Apr;18(4):863-70.
REF 5 Regulation of human microsomal prostaglandin E synthase-1 by IL-1 requires a distal enhancer element with a unique role for C/EBP. Biochem J. 2012 Apr 15;443(2):561-71.
REF 6 Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene. J Biol Chem. 2003 Nov 7;278(45):44246-54.

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