| References |
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| REF 1 |
The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 Jun 28;16(1):37-47.
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| REF 2 |
Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell. 2010 Jul 9;39(1):71-85.
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| REF 3 |
MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 2011 Jun 10;42(5):700-12.
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| REF 4 |
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 2013 Jun 6;153(6):1327-39.
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| REF 5 |
Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex. J Am Chem Soc. 2013 Mar 20;135(11):4537-49.
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| REF 6 |
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell. 2004 Jul;6(1):33-43.
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| REF 7 |
TRAF6 upregulates expression of HIF-1 and promotes tumor angiogenesis. Cancer Res. 2013 Aug 1;73(15):4950-9.
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| REF 8 |
A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1 activation, tumorigenesis andmetastasis. Nat Cell Biol. 2017 Jan;19(1):38-51.
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| REF 9 |
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem. 2010 Feb 5;285(6):3651-63.
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| REF 10 |
Functional regulation of hypoxia inducible factor-1 by SET9 lysine methyltransferase. Biochim Biophys Acta. 2015 May;1853(5):881-91.
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| REF 11 |
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell. 2010 Jun 25;38(6):864-78.
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| REF 12 |
HIF1 protein stability is increased by acetylation at lysine 709. J Biol Chem. 2012 Oct 12;287(42):35496-505.
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| REF 13 |
A unique SUMO-2-interacting motif within LANA is essential for KSHV latency. PLoS Pathog. 2013;9(11):e1003750.
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| REF 14 |
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007 Nov 16;282(46):33358-66.
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| REF 15 |
Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep. 2007 Mar;17(3):647-51.
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| REF 16 |
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
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| REF 17 |
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001 Oct 15;15(20):2675-86.
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| REF 18 |
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett. 2009 Jan 5;583(1):55-60.
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| REF 19 |
Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem. 2004 Oct 1;279(40):41966-74.
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| REF 20 |
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1 protein under hypoxic conditions. PLoS One. 2012;7(3):e33433.
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| REF 21 |
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription. J Biol Chem. 2001 Jul 27;276(30):28421-9.
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| REF 22 |
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
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| REF 23 |
NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. EMBO Rep. 2008 May;9(5):486-91.
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| REF 24 |
Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha. FEBS J. 2009 Jul;276(13):3470-80.
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| REF 25 |
von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase. Int J Biochem Cell Biol. 2011 May;43(5):795-804.
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| REF 26 |
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2006 Mar;26(6):2019-28.
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| REF 27 |
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem. 2004 Apr 2;279(14):13506-13.
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| REF 28 |
Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Res. 2006 Sep 1;66(17):8814-21.
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| REF 29 |
MafG controls the hypoxic response of cells by accumulating HIF-1alpha in the nuclei. FEBS Lett. 2008 Jul 9;582(16):2357-64.
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| REF 30 |
COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70. PLoS One. 2009 Oct 5;4(10):e7332.
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| REF 31 |
Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci. 2005 Jan 15;118(Pt 2):301-11.
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| REF 32 |
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005 Apr 28;24(19):3110-20.
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| REF 33 |
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1 to promote cell-cycle progression. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3325-34.
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| REF 34 |
Identification of proteins associated with ligand-activated estrogen receptor in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Proteomics. 2011 Jan;11(1):172-9.
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| REF 35 |
Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells. Mol Endocrinol. 2005 May;19(5):1191-9.
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| REF 36 |
NQO1 inhibits proteasome-mediated degradation of HIF-1. Nat Commun. 2016 Dec 14;7:13593.
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| REF 37 |
Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1. PLoS One. 2015 May 14;10(5):e0123725.
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| REF 38 |
Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling. J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76.
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| REF 39 |
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):654-9.
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| REF 40 |
HEXIM1 down-regulates hypoxia-inducible factor-1 protein stability. Biochem J. 2013 Dec 1;456(2):195-204.
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| REF 41 |
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol Cell Biol. 2007 May;27(10):3758-68.
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| REF 42 |
A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
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| REF 43 |
A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}. Mol Cancer Ther. 2008 Dec;7(12):3729-38.
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| REF 44 |
Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40.
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| REF 45 |
CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016 Jan 1;129(1):191-205.
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| REF 46 |
HIF1-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5. PLoS One. 2015 Sep 9;10(9):e0137513.
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| REF 47 |
Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev. 2004 Apr 1;18(7):739-44.
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| REF 48 |
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem. 2003 Apr 18;278(16):13595-8.
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| REF 49 |
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10305-9.
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| REF 50 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 51 |
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest. 2010 Jun;120(6):2119-30.
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| REF 52 |
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. J Cell Sci. 1999 Apr;112 ( Pt 8):1203-12.
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| REF 53 |
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013 Jul 17;135(28):10418-25.
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| REF 54 |
K63-polyubiquitinated HAUSP deubiquitinates HIF-1 and dictates H3K56 acetylation promoting hypoxia-induced tumour progression. Nat Commun. 2016 Dec 9;7:13644.
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| REF 55 |
The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2. Biochem J. 2004 Aug 1;381(Pt 3):685-91.
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| REF 56 |
Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. J Biol Chem. 2010 Jan 22;285(4):2601-9.
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| REF 57 |
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J. 1999 Apr 1;18(7):1905-14.
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| REF 58 |
A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads. J Mol Biol. 2004 Feb 6;336(1):9-24.
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| REF 59 |
Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001 Oct 19;276(42):38527-35.
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| REF 60 |
Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem. 2002 Nov 15;277(46):43799-808.
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| REF 61 |
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J. 2006 Oct 18;25(20):4784-94.
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| REF 62 |
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell. 2005 Mar 18;17(6):793-803.
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| REF 63 |
CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction. Carcinogenesis. 2008 Feb;29(2):291-8.
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| REF 64 |
Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem. 2011 Oct 21;286(42):36808-19.
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| REF 65 |
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J. 2004 May 5;23(9):1949-56.
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| REF 66 |
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J. 2006 Mar 22;25(6):1231-41.
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| REF 67 |
Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha. Oncol Rep. 2006 Oct;16(4):929-35.
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| REF 68 |
Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. Cancer Res. 2007 Jan 15;67(2):450-4.
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| REF 69 |
Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1alpha. Carcinogenesis. 2009 Oct;30(10):1768-75.
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| REF 70 |
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999 May 20;399(6733):271-5.
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| REF 71 |
A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography. Nat Med. 2010 Aug;16(8):921-6.
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| REF 72 |
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science. 2016 Aug 26;353(6302):929-32.
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| REF 73 |
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000 Jul;2(7):423-7.
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| REF 74 |
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. J Biol Chem. 2012 Feb 24;287(9):6139-49.
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