Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Transcription intermediary factor 1-beta (TRIM28) | Literature-reported | Target Info | ||
| UniProt ID | TIF1B_HUMAN | ||||
| Gene Name | TRIM28 | ||||
| Gene ID | 10155 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Histone deacetylase 1 (HDAC1) | Target Info | PPI Info | [1] | |
| Enhancer of zeste homolog 2 (EZH2) | Target Info | PPI Info | [5] | ||
| Interacting Clinical trial Target(s) | NAD-dependent deacetylase sirtuin-1 (SIRT1) | Target Info | PPI Info | [2] | |
| Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [3] | ||
| ATM serine/threonine kinase (ATM) | Target Info | PPI Info | [4] | ||
| Hypoxia-inducible factor 1 alpha (HIF-1A) | Target Info | PPI Info | [6] | ||
| Melanoma-associated antigen 3 (MAGEA3) | Target Info | PPI Info | [7] | ||
| Melanoma-associated antigen C2 (MAGEC2) | Target Info | PPI Info | [7] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The TRIM family protein KAP1 inhibits HIV-1 integration. Cell Host Microbe. 2011 Jun 16;9(6):484-95. | ||||
| REF 2 | USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012 May 25;46(4):484-94. | ||||
| REF 3 | MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J. 2005 Sep 21;24(18):3279-90. | ||||
| REF 4 | MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. J Invest Dermatol. 2013 Mar;133(3):759-767. | ||||
| REF 5 | The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127. | ||||
| REF 6 | A unique SUMO-2-interacting motif within LANA is essential for KSHV latency. PLoS Pathog. 2013;9(11):e1003750. | ||||
| REF 7 | MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.