Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T71907 Target Info
Target Name Survival motor neuron protein (SMN1)
Synonyms SMNT; SMNC; SMN2; SMN; Gemin-1; Component of gems 1
Target Type Successful Target
Gene Name SMN1
UniProt ID
SMN_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Probable ATP-dependent RNA helicase DDX20 (DDX20) Interacting Protein Interacting Protein Info
UniProt ID
DDX20_HUMAN 
Synonyms DP103; GEMIN3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-fractionation [3]
4 Co-purification [3]
Actins [+] 1 Actins +
Interacting Protein Name Beta-actin (ACTB) Interacting Protein Interacting Protein Info
UniProt ID
ACTB_HUMAN 
Synonyms BRWS1; PS1TP5BP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [5]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name Gem-associated protein 5 (GEMIN5) Interacting Protein Interacting Protein Info
UniProt ID
GEMI5_HUMAN 
Synonyms GEMIN.5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [6]
Interacting Target Name UNR-interacting protein (STRAP) Literature-reported Target Interacting Protein Info
UniProt ID
STRAP_HUMAN 
Synonyms WD-40 repeat protein PT-WD; UNRIP; UNR-interacting protein; MAWD; MAP activator with WD repeats
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [7]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name Histone-glutamine methyltransferase (FBL) Interacting Protein Interacting Protein Info
UniProt ID
FBRL_HUMAN 
Synonyms FIB; FLRN; RNU3IP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [8]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Yeast two hybrid [5]
Ribosomal proteins [+] 1 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein eL13 (RPL13) Interacting Protein Interacting Protein Info
UniProt ID
RL13_HUMAN 
Synonyms BBC1; D16S444E; D16S44E; L13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [5]
Other proteins [+] 12 Other proteins +
Interacting Protein Name Gem-associated protein 2 (GEMIN2) Interacting Protein Interacting Protein Info
UniProt ID
GEMI2_HUMAN 
Synonyms SIP1; SIP1.delta
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [2]
3 Co-fractionation [3]
4 Co-purification [3]
5 Reconstituted Complex [10]
6 Yeast two hybrid [5]
Interacting Protein Name Gem-associated protein 4 (GEMIN4) Interacting Protein Interacting Protein Info
UniProt ID
GEMI4_HUMAN 
Synonyms HC56; HCAP1; HHRF.1; p97
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [2]
3 Co-fractionation [3]
4 Co-purification [3]
Interacting Protein Name Small nuclear ribonucleoprotein Sm D1 (SNRPD1) Interacting Protein Interacting Protein Info
UniProt ID
SMD1_HUMAN 
Synonyms HsT2456; SMD1; SNRPD; Sm.D1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [3]
3 Co-purification [3]
4 Reconstituted Complex [10]
Interacting Protein Name Small nuclear ribonucleoprotein Sm D2 (SNRPD2) Interacting Protein Interacting Protein Info
UniProt ID
SMD2_HUMAN 
Synonyms SMD2; SNRPD1; Sm.D2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-fractionation [3]
3 Co-purification [3]
4 Reconstituted Complex [11]
Interacting Protein Name Far upstream element-binding protein 1 (FUBP1) Interacting Protein Interacting Protein Info
UniProt ID
FUBP1_HUMAN 
Synonyms FBP; FUBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [12]
3 Yeast two hybrid [12]
Interacting Protein Name Small nuclear ribonucleoprotein polypeptides B and B1 (SNRPB) Interacting Protein Interacting Protein Info
UniProt ID
RSMB_HUMAN 
Synonyms COD; SNRPB1; Sm.B/B; SmB/B; SmB/SmB; snRNP.B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [13]
3 Reconstituted Complex [14]
Interacting Protein Name Gem-associated protein 7 (GEMIN7) Interacting Protein Interacting Protein Info
UniProt ID
GEMI7_HUMAN 
Synonyms SIP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [15]
Interacting Protein Name Gem-associated protein 8 (GEMIN8) Interacting Protein Interacting Protein Info
UniProt ID
GEMI8_HUMAN 
Synonyms FAM51A1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [16]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein R (HNRNPR) Interacting Protein Interacting Protein Info
UniProt ID
HNRPR_HUMAN 
Synonyms HNRPR; hnRNP.R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [17]
Interacting Protein Name U7 snRNA-associated Sm-like protein LSm10 (LSM10) Interacting Protein Interacting Protein Info
UniProt ID
LSM10_HUMAN 
Synonyms MST074; MSTP074
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [11]
Interacting Protein Name U7 snRNA-associated Sm-like protein LSm11 (LSM11) Interacting Protein Interacting Protein Info
UniProt ID
LSM11_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [11]
Interacting Protein Name Gem-associated protein 6 (GEMIN6) Interacting Protein Interacting Protein Info
UniProt ID
GEMI6_HUMAN 
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
References  Top
REF 1 Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. J Cell Biol. 1999 Dec 13;147(6):1181-94.
REF 2 Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs. J Cell Sci. 2003 May 15;116(Pt 10):1905-13.
REF 3 Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins. Hum Mol Genet. 2000 Aug 12;9(13):1977-86.
REF 4 The SMN interactome includes Myb-binding protein 1a. J Proteome Res. 2010 Jan;9(1):556-63.
REF 5 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 6 Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem. 2002 Feb 15;277(7):5631-6.
REF 7 A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex. PLoS One. 2014 Jun 12;9(6):e99493.
REF 8 The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr Biol. 2001 Jul 24;11(14):1079-88.
REF 9 A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy. J Biol Chem. 2002 Jan 25;277(4):2852-9.
REF 10 The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell. 1997 Sep 19;90(6):1013-21.
REF 11 Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. J Biol Chem. 2005 Oct 14;280(41):34435-40.
REF 12 The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain. FEBS Lett. 2000 Mar 24;470(2):207-10.
REF 13 Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron. J Biol Chem. 2012 Dec 21;287(52):43741-52.
REF 14 Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein. RNA. 2001 Nov;7(11):1531-42.
REF 15 Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem. 2002 Mar 1;277(9):7540-5.
REF 16 Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity. Hum Mol Genet. 2016 Apr 1;25(7):1392-405.
REF 17 SMN interacts with a novel family of hnRNP and spliceosomal proteins. EMBO J. 2001 Oct 1;20(19):5443-52.

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