Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80423 Target Info
Target Name von Hippel-Lindau disease tumor suppressor (VHL)
Synonyms pVHL; Protein G7
Target Type Patented-recorded Target
Gene Name VHL
UniProt ID
VHL_HUMAN 
Target Interacting Proteins  Top
Actins [+] 1 Actins +
Interacting Protein Name Beta-actin (ACTB) Interacting Protein Interacting Protein Info
UniProt ID
ACTB_HUMAN 
Synonyms BRWS1; PS1TP5BP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RBX1 (RBX1) Interacting Protein Interacting Protein Info
UniProt ID
RBX1_HUMAN 
Synonyms BA554C12.1; RNF75; ROC1
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [9]
8 Affinity Capture-Western [10]
9 Affinity Capture-Western [11]
10 Co-purification [12]
Interacting Protein Name E3 SUMO-protein ligase PIAS4 (PIAS4) Interacting Protein Interacting Protein Info
UniProt ID
PIAS4_HUMAN 
Synonyms PIASY; Piasg; ZMIZ6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [14]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [16]
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Reconstituted Complex [16]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [17]
3 Yeast two hybrid [18]
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-2 (CUL2) Interacting Protein Interacting Protein Info
UniProt ID
CUL2_HUMAN 
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [1]
5 Affinity Capture-MS [20]
6 Affinity Capture-MS [21]
7 Affinity Capture-MS [22]
8 Affinity Capture-MS [5]
9 Affinity Capture-MS [23]
10 Affinity Capture-Western [8]
11 Affinity Capture-Western [24]
12 Affinity Capture-Western [25]
13 Affinity Capture-Western [26]
14 Affinity Capture-Western [7]
15 Affinity Capture-Western [27]
16 Affinity Capture-Western [28]
17 Affinity Capture-Western [29]
18 Affinity Capture-Western [2]
19 Affinity Capture-Western [23]
20 Affinity Capture-Western [30]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Kinases [+] 4 Kinases +
Interacting Protein Name DNA-directed RNA polymerase II subunit RPB1 (POLR2A) Interacting Protein Interacting Protein Info
UniProt ID
RPB1_HUMAN 
Synonyms POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Affinity Capture-Western [23]
3 Affinity Capture-Western [10]
4 Protein-peptide [10]
Interacting Target Name Aurora kinase A (AURKA) Clinical trial Target Interacting Protein Info
UniProt ID
AURKA_HUMAN 
Synonyms STK6; STK15; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; IAK1; hARK1; BTAK; Breast tumor-amplified kinase; AYK1; Aurora-related kinase 1; Aurora-A; Aurora/IPL1-related kinase 1; Aurora 2; AURA; ARK-1; ARK1; AIRK1; AIK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Affinity Capture-Western [33]
3 Biochemical Activity [33]
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Biochemical Activity [34]
Interacting Target Name Protein kinase C delta (PRKCD) Clinical trial Target Interacting Protein Info
UniProt ID
KPCD_HUMAN 
Synonyms Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; Protein Kinase C delta; PKC-delta; nPKC-delta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Fluorescence Resonance Energy Transfer [36]
Lyases [+] 1 Lyases +
Interacting Protein Name Small ribosomal subunit protein uS3 (RPS3) Interacting Protein Interacting Protein Info
UniProt ID
RS3_HUMAN 
Synonyms S3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [37]
3 Co-fractionation [37]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [38]
2 Reconstituted Complex [39]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name HIF-prolyl hydroxylase 2 (HPH-2) Patented-recorded Target Interacting Protein Info
UniProt ID
EGLN1_HUMAN 
Synonyms SM-20; SM20; Prolyl hydroxylase domain-containing protein 2; Prolyl hydroxylase domaincontaining protein 2; PNAS-137; PNAS-118; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; Hypoxiainducible factor prolyl hydroxylase 2; HPH2; HIFprolyl hydroxylase 2; HIF-PH2; HIFPH2; Egl nine homolog 1; C1orf12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Reconstituted Complex [41]
Peptidases [+] 1 Peptidases +
Interacting Target Name VHL-interacting deubiquitinating enzyme 1 (VDU1) Patented-recorded Target Interacting Protein Info
UniProt ID
UBP33_HUMAN 
Synonyms Ubiquitin-specific-processing protease 33; Ubiquitin thioesterase 33; Ubiquitin carboxyl-terminal hydrolase 33; KIAA1097; hVDU1; Deubiquitinating enzyme 33
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Affinity Capture-Western [43]
3 Biochemical Activity [42]
4 Reconstituted Complex [42]
5 Yeast two hybrid [42]
6 Yeast two hybrid [43]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [44]
3 Affinity Capture-Western [1]
4 Reconstituted Complex [44]
Ribosomal proteins [+] 2 Ribosomal proteins +
Interacting Protein Name Small ribosomal subunit protein uS8 (RPS15A) Interacting Protein Interacting Protein Info
UniProt ID
RS15A_HUMAN 
Synonyms S15a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Protein Name Small ribosomal subunit protein eS1 (RPS3A) Interacting Protein Interacting Protein Info
UniProt ID
RS3A_HUMAN 
Synonyms FTE1; MFTL; S3A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [37]
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-MS [20]
3 Affinity Capture-MS [23]
4 Affinity Capture-Western [45]
5 Affinity Capture-Western [46]
6 Affinity Capture-Western [47]
7 Affinity Capture-Western [48]
8 Affinity Capture-Western [49]
9 Affinity Capture-Western [25]
10 Affinity Capture-Western [50]
11 Affinity Capture-Western [51]
12 Affinity Capture-Western [52]
13 Affinity Capture-Western [53]
14 Affinity Capture-Western [54]
15 Affinity Capture-Western [55]
16 Affinity Capture-Western [56]
17 Affinity Capture-Western [57]
18 Affinity Capture-Western [58]
19 Affinity Capture-Western [59]
20 Affinity Capture-Western [20]
Interacting Target Name Hypoxia-inducible factor 2 alpha (HIF-2A) Successful Target Interacting Protein Info
UniProt ID
EPAS1_HUMAN 
Synonyms PASD2; PAS domain-containing protein 2; MOP2; Member of PAS protein 2; Hypoxia-inducible factor 2-alpha; HLF; HIF-2-alpha; HIF2-alpha; HIF2A; HIF-1-alpha-like factor; EPAS-1; Endothelial PAS domain-containing protein 1; Class E basic helix-loop-helix protein 73; bHLHe73; Basic-helix-loop-helix-PAS protein MOP2
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-Western [60]
3 Affinity Capture-Western [45]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [23]
6 Affinity Capture-Western [10]
7 Affinity Capture-Western [61]
8 Affinity Capture-Western [62]
9 Affinity Capture-Western [63]
10 Affinity Capture-Western [64]
11 Affinity Capture-Western [65]
12 Affinity Capture-Western [66]
13 Reconstituted Complex [61]
14 Yeast two hybrid [67]
Interacting Protein Name Protein Jade-1 (JADE1) Interacting Protein Interacting Protein Info
UniProt ID
JADE1_HUMAN 
Synonyms PHF17
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Reconstituted Complex [68]
3 Yeast two hybrid [69]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Reconstituted Complex [71]
Other proteins [+] 18 Other proteins +
Interacting Protein Name Elongin-C (ELOC) Interacting Protein Interacting Protein Info
UniProt ID
ELOC_HUMAN 
Synonyms SIII; eloC
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [1]
5 Affinity Capture-MS [21]
6 Affinity Capture-MS [5]
7 Affinity Capture-MS [23]
8 Affinity Capture-Western [8]
9 Affinity Capture-Western [27]
10 Affinity Capture-Western [52]
11 Affinity Capture-Western [72]
12 Affinity Capture-Western [73]
13 Affinity Capture-Western [2]
14 Affinity Capture-Western [22]
15 Affinity Capture-Western [23]
16 Affinity Capture-Western [74]
17 Affinity Capture-Western [10]
18 Affinity Capture-Western [61]
19 Affinity Capture-Western [75]
20 Affinity Capture-Western [62]
Interacting Protein Name Elongin-B (ELOB) Interacting Protein Interacting Protein Info
UniProt ID
ELOB_HUMAN 
Synonyms ELOB; SIII
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [1]
5 Affinity Capture-MS [20]
6 Affinity Capture-MS [21]
7 Affinity Capture-MS [5]
8 Affinity Capture-MS [23]
9 Affinity Capture-Western [8]
10 Affinity Capture-Western [25]
11 Affinity Capture-Western [27]
12 Affinity Capture-Western [73]
13 Affinity Capture-Western [2]
14 Affinity Capture-Western [22]
15 Affinity Capture-Western [30]
16 Affinity Capture-Western [74]
17 Affinity Capture-Western [76]
18 Affinity Capture-Western [9]
19 Affinity Capture-Western [10]
20 Affinity Capture-Western [61]
Interacting Target Name Fibronectin (FN1) Clinical trial Target Interacting Protein Info
UniProt ID
FINC_HUMAN 
Synonyms Ugl-Y3; Ugl-Y2; Ugl-Y1; FN; Cold-insoluble globulin; CIG
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [77]
3 Affinity Capture-Western [27]
4 Affinity Capture-Western [78]
5 Affinity Capture-Western [75]
6 Affinity Capture-Western [79]
7 Affinity Capture-Western [80]
8 Affinity Capture-Western [81]
Interacting Protein Name Collagen alpha-2(IV) chain (COL4A2) Interacting Protein Interacting Protein Info
UniProt ID
CO4A2_HUMAN 
Synonyms ICH; POREN2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [78]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [20]
4 Affinity Capture-Western [78]
5 Affinity Capture-Western [20]
Interacting Protein Name Collagen alpha-1(IV) chain (COL4A1) Interacting Protein Interacting Protein Info
UniProt ID
CO4A1_HUMAN 
Synonyms BSVD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [78]
4 Affinity Capture-Western [20]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) Interacting Protein Interacting Protein Info
UniProt ID
HNRPD_HUMAN 
Synonyms AUF1; AUF1A; HNRPD; P37; hnRNPD0
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [82]
3 Biochemical Activity [82]
4 Reconstituted Complex [82]
Interacting Protein Name Prefoldin subunit 3 (VBP1) Interacting Protein Interacting Protein Info
UniProt ID
PFD3_HUMAN 
Synonyms PFD3; PFDN3; VBP.1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [83]
2 Affinity Capture-Western [72]
3 Yeast two hybrid [69]
4 Yeast two hybrid [83]
Interacting Target Name Translationally-controlled tumor protein (TPT1) Discontinued Target Interacting Protein Info
UniProt ID
TCTP_HUMAN 
Synonyms TPT1; TCTP; p23; HRF; Histamine-releasing factor; Fortilin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [70]
3 Reconstituted Complex [70]
Interacting Target Name ELAV-like protein 1 (ELAVL1) Literature-reported Target Interacting Protein Info
UniProt ID
ELAV1_HUMAN 
Synonyms HuR; Hu-antigen R
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [84]
2 Affinity Capture-Western [85]
3 Reconstituted Complex [84]
Interacting Protein Name Hepatocellular carcinoma-associated antigen 57 (DNAJA3) Interacting Protein Interacting Protein Info
UniProt ID
DNJA3_HUMAN 
Synonyms HCA57; TID1; hTID.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [86]
3 Reconstituted Complex [86]
Interacting Protein Name Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) Interacting Protein Interacting Protein Info
UniProt ID
ROA2_HUMAN 
Synonyms HNRPA2B1; hnRNP A2/B1; Heterogeneous nuclear ribonucleoproteins A2/B1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [87]
3 Affinity Capture-Western [88]
Interacting Protein Name T-complex protein 1 subunit alpha (TCP1) Interacting Protein Interacting Protein Info
UniProt ID
TCPA_HUMAN 
Synonyms CCT.alpha; CCT1; CCTa; D6S230E; TCP.1.alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [57]
Interacting Protein Name Collagen alpha-3(IV) chain (COL4A3) Interacting Protein Interacting Protein Info
UniProt ID
CO4A3_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [20]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein L (HNRNPL) Interacting Protein Interacting Protein Info
UniProt ID
HNRPL_HUMAN 
Synonyms HNRPL; hnRNP.L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [87]
Interacting Protein Name Tubulin alpha-1A chain (TUBA1A) Interacting Protein Interacting Protein Info
UniProt ID
TBA1A_HUMAN 
Synonyms B.ALPHA.1; LIS3; TUBA3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [89]
Interacting Protein Name T-complex protein 1 subunit epsilon (CCT5) Interacting Protein Interacting Protein Info
UniProt ID
TCPE_HUMAN 
Synonyms CCT.epsilon; CCTE; HEL.S.69; TCP.1.epsilon
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-MS [1]
Interacting Protein Name T-complex protein 1 subunit gamma (CCT3) Interacting Protein Interacting Protein Info
UniProt ID
TCPG_HUMAN 
Synonyms CCT.gamma; CCTG; PIG48; TCP.1.gamma; TRIC5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [29]
Interacting Protein Name T-complex protein 1 subunit eta (CCT7) Interacting Protein Interacting Protein Info
UniProt ID
TCPH_HUMAN 
Synonyms CCTETA; CCTH; NIP7.1; TCP1ETA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-MS [1]
References  Top
REF 1 Proteomic dissection of the von Hippel-Lindau (VHL) interactome. J Proteome Res. 2011 Nov 4;10(11):5175-82.
REF 2 The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1. Arch Biochem Biophys. 2012 Feb 15;518(2):103-10.
REF 3 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 2004 Dec 15;18(24):3055-65.
REF 4 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 5 The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Oncogene. 2015 Feb 5;34(6):771-9.
REF 6 ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. FEBS Lett. 2005 Dec 19;579(30):6796-802.
REF 7 DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase. Mol Cell Biol. 2013 Apr;33(8):1621-31.
REF 8 An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016 Jan 14;529(7585):172-7.
REF 9 A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase. J Biol Chem. 2002 Aug 16;277(33):30388-93.
REF 10 von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2706-11.
REF 11 Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions. Oncogene. 2006 Jan 19;25(3):370-7.
REF 12 Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. Biochemistry. 2006 Mar 7;45(9):3014-9.
REF 13 PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells. Br J Cancer. 2013 Oct 1;109(7):1795-804.
REF 14 Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS One. 2010 Mar 16;5(3):e9720.
REF 15 pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases. Mol Cells. 2012 Feb;33(2):195-201.
REF 16 FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001 Oct 15;15(20):2675-86.
REF 17 Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6459-63.
REF 18 Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein. Sci Rep. 2015 Jul 27;5:12605.
REF 19 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 20 Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor. J Biol Chem. 2007 May 4;282(18):13264-9.
REF 21 Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. J Biol Chem. 2008 Mar 21;283(12):8005-13.
REF 22 The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2156-61.
REF 23 Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep. 2017 Aug 3;7(1):7190.
REF 24 Substrate-mediated regulation of cullin neddylation. J Biol Chem. 2007 Jun 8;282(23):17032-40.
REF 25 Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex. EMBO Mol Med. 2009 Apr;1(1):66-78.
REF 26 Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex. Neoplasia. 2006 Nov;8(11):956-63.
REF 27 NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. EMBO Rep. 2008 May;9(5):486-91.
REF 28 Dynamic HIF1A regulation during human placental development. Biol Reprod. 2006 Jul;75(1):112-21.
REF 29 Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity. Mol Cell Biol. 2002 Mar;22(6):1947-60.
REF 30 Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein. J Clin Invest. 1999 Dec;104(11):1583-91.
REF 31 The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. Mol Cell Biol. 2008 Apr;28(8):2701-17.
REF 32 Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC). PLoS One. 2013 Jun 13;8(6):e67071.
REF 33 Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Oncogene. 2017 Jun 15;36(24):3450-3463.
REF 34 Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain. J Biol Chem. 2005 Jun 10;280(23):22205-11.
REF 35 Von Hippel-Lindau regulates interleukin-32 stability in ovarian cancer cells. Oncotarget. 2017 Jul 17;8(41):69833-69846.
REF 36 The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta. Biochem J. 2006 Jul 1;397(1):109-20.
REF 37 The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis. J Biol Chem. 2013 Jun 7;288(23):16588-97.
REF 38 Regulation of the transcriptional activation of the androgen receptor by the UXT-binding protein VHL. Biochem J. 2013 Nov 15;456(1):55-66.
REF 39 The von hippel-lindau protein suppresses androgen receptor activity. Mol Endocrinol. 2014 Feb;28(2):239-48.
REF 40 The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol. 2012 Jan 29;14(2):201-8.
REF 41 RHOBTB3 promotes proteasomal degradation of HIF through facilitating hydroxylation and suppresses the Warburg effect. Cell Res. 2015 Sep;25(9):1025-42.
REF 42 Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2002 Feb 15;277(7):4656-62.
REF 43 Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14530-5.
REF 44 p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell. 2006 May 5;22(3):395-405.
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