Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T82254 Target Info
Target Name Apoptosis regulator BAK (BAK)
Synonyms CDN1; Bcl2like protein 7; Bcl2L7; Bcl2-L-7; Bcl2 homologous antagonist/killer; Bcl-2-like protein 7; Bcl-2 homologous antagonist/killer
Target Type Literature-reported Target
Gene Name BAK1
Biochemical Class B-cell lymphoma Bcl-2
UniProt ID
BAK_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target Interacting Protein Info
UniProt ID
B2CL1_HUMAN 
Synonyms Bcl-XL; BCLX; Bcl-2-like protein 1; Bcl2like protein 1; Bcl2-L-1; Bcl2L1; BCL2L; Apoptosis regulator Bcl-X
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Fluorescence Resonance Energy Transfer [4]
5 Protein-peptide [5]
6 Reconstituted Complex [6]
7 Yeast two hybrid [7]
8 Yeast two hybrid [2]
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Target Name Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Clinical trial Target Interacting Protein Info
UniProt ID
MCL1_HUMAN 
Synonyms mcl1/EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-related protein EAT/mcl1; Bcl-2-like protein 3; Bcl2-L-3; BCL2L3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [3]
4 Protein-peptide [10]
5 Reconstituted Complex [11]
6 Yeast two hybrid [12]
Interacting Target Name Apoptosis regulator Bcl-2 (BCL-2) Successful Target Interacting Protein Info
UniProt ID
BCL2_HUMAN 
Synonyms Bcl-2; Apoptosis regulator Bcl-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Protein-peptide [14]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [11]
3 Co-fractionation [15]
4 Reconstituted Complex [11]
References  Top
REF 1 Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol. 1999 Mar 8;144(5):903-14.
REF 2 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 3 Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis. Biochem Pharmacol. 2011 Jan 1;81(1):32-42.
REF 4 High-throughput methods to detect dimerization of Bcl-2 family proteins. Anal Biochem. 2003 Nov 15;322(2):170-8.
REF 5 Development of a high-throughput fluorescence polarization assay for Bcl-x(L). Anal Biochem. 2002 Aug 1;307(1):70-5.
REF 6 Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb;3(2):173-82.
REF 7 An empirical framework for binary interactome mapping. Nat Methods. 2009 Jan;6(1):83-90.
REF 8 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 9 Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88.
REF 10 Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 2005 Jun 1;19(11):1294-305.
REF 11 Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 2004 May;6(5):443-50.
REF 12 MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J Biol Chem. 2000 Aug 18;275(33):25255-61.
REF 13 Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 2004 Feb 20;116(4):527-40.
REF 14 Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem. 2001 Dec 6;44(25):4313-24.
REF 15 Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. J Biol Chem. 2011 Aug 19;286(33):28749-60.

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