Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T69200 Target Info
Target Name Mitotic growth and transcription activator (BAF190A)
Synonyms Transcription activator BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SNF2L4; SNF2B; SNF2-beta; Protein brahma homolog 1; Protein BRG-1; BRG1-associated factor 190A; BRG1; ATP-dependent helicase SMARCA4
Target Type Literature-reported Target
Gene Name SMARCA4
Biochemical Class Acid anhydride hydrolase
UniProt ID
SMCA4_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Chromodomain-helicase-DNA-binding protein 4 (CHD4) Interacting Protein Interacting Protein Info
UniProt ID
CHD4_HUMAN 
Synonyms CHD.4; Mi.2b; Mi2.BETA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Yeast two hybrid [1]
Interacting Protein Name Probable global transcription activator SNF2L2 (SMARCA2) Interacting Protein Interacting Protein Info
UniProt ID
SMCA2_HUMAN 
Synonyms BAF190; BRM; NCBRS; SNF2; SNF2L2; SNF2LA; SWI2; Sth1p; hBRM; hSNF2a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-fractionation [4]
Actins [+] 2 Actins +
Interacting Protein Name Actin-like protein 6A (ACTL6A) Interacting Protein Interacting Protein Info
UniProt ID
ACL6A_HUMAN 
Synonyms ACTL6; ARPN.BETA; Arp4; BAF53A; INO80K
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [7]
4 Co-fractionation [8]
5 Co-purification [9]
Interacting Protein Name Beta-actin (ACTB) Interacting Protein Interacting Protein Info
UniProt ID
ACTB_HUMAN 
Synonyms BRWS1; PS1TP5BP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [10]
3 Co-purification [11]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [15]
5 Co-purification [16]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [12]
4 Affinity Capture-Western [19]
5 Co-fractionation [4]
Histones [+] 1 Histones +
Interacting Target Name Gamma-Histone H2AX (H2AFX) Literature-reported Target Interacting Protein Info
UniProt ID
H2AX_HUMAN 
Synonyms Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [21]
Kinases [+] 1 Kinases +
Interacting Protein Name DNA-directed RNA polymerase II subunit RPB1 (POLR2A) Interacting Protein Interacting Protein Info
UniProt ID
RPB1_HUMAN 
Synonyms POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [22]
3 Co-fractionation [4]
4 Co-localization [23]
5 Co-purification [16]
6 Co-purification [9]
Nuclear hormone receptors [+] 2 Nuclear hormone receptors +
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Co-fractionation [4]
3 Proximity Label-MS [25]
4 Reconstituted Complex [26]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Proximity Label-MS [25]
3 Yeast two hybrid [28]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name Protein arginine methyltransferase 5 (PRMT5) Clinical trial Target Interacting Protein Info
UniProt ID
ANM5_HUMAN 
Synonyms SKB1Hs; SKB1 homolog; SKB1; Shk1 kinase-binding protein 1 homolog; Protein arginine N-methyltransferase 5; JBP1; Jak-binding protein 1; IBP72; HRMT1L5; Histone-arginine N-methyltransferase PRMT5; 72 kDa ICln-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Co-fractionation [29]
3 Reconstituted Complex [29]
Transcription regulators [+] 8 Transcription regulators +
Interacting Protein Name SWI/SNF complex subunit SMARCC1 (SMARCC1) Interacting Protein Interacting Protein Info
UniProt ID
SMRC1_HUMAN 
Synonyms BAF155; CRACC1; Rsc8; SRG3; SWI3
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-Western [31]
5 Affinity Capture-Western [30]
6 Affinity Capture-Western [5]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [6]
9 Affinity Capture-Western [32]
10 Affinity Capture-Western [33]
11 Affinity Capture-Western [2]
12 Affinity Capture-Western [34]
13 Affinity Capture-Western [35]
14 Affinity Capture-Western [36]
15 Co-fractionation [8]
16 Co-fractionation [37]
17 Co-purification [16]
18 Co-purification [9]
Interacting Protein Name SWI/SNF complex subunit SMARCC2 (SMARCC2) Interacting Protein Interacting Protein Info
UniProt ID
SMRC2_HUMAN 
Synonyms BAF170; CRACC2; Rsc8
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [31]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [11]
6 Affinity Capture-Western [33]
7 Affinity Capture-Western [38]
8 Co-fractionation [8]
9 Co-fractionation [37]
10 Co-purification [9]
11 Co-purification [11]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [39]
2 Affinity Capture-Western [40]
3 Reconstituted Complex [5]
Interacting Protein Name Myelin expression factor 2 (MYEF2) Interacting Protein Interacting Protein Info
UniProt ID
MYEF2_HUMAN 
Synonyms HsT18564; MEF.2; MST156; MSTP156; myEF.2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Affinity Capture-Western [42]
3 Co-localization [41]
Interacting Protein Name BRG1-associated factor 60A (SMARCD1) Interacting Protein Interacting Protein Info
UniProt ID
SMRD1_HUMAN 
Synonyms BAF60A; CRACD1; Rsc6p
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Co-fractionation [37]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Reconstituted Complex [44]
Interacting Protein Name BRG1-associated factor 60B (SMARCD2) Interacting Protein Interacting Protein Info
UniProt ID
SMRD2_HUMAN 
Synonyms BAF60B; CRACD2; Rsc6p
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-fractionation [37]
Interacting Protein Name BRG1-associated factor 60C (SMARCD3) Interacting Protein Interacting Protein Info
UniProt ID
SMRD3_HUMAN 
Synonyms BAF60C; CRACD3; Rsc6p
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [45]
2 Co-fractionation [37]
Other proteins [+] 7 Other proteins +
Interacting Protein Name Integrase interactor 1 protein (SMARCB1) Interacting Protein Interacting Protein Info
UniProt ID
SNF5_HUMAN 
Synonyms BAF47; INI1; MRD15; PPP1R144; RDT; RTPS1; SNF5; SNF5L1; SWNTS1; Sfh1p; Snr1; hSNFS
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-Western [31]
5 Affinity Capture-Western [30]
6 Affinity Capture-Western [7]
7 Affinity Capture-Western [11]
8 Affinity Capture-Western [32]
9 Affinity Capture-Western [38]
10 Affinity Capture-Western [3]
11 Affinity Capture-Western [46]
12 Affinity Capture-Western [47]
13 Affinity Capture-Western [34]
14 Affinity Capture-Western [48]
15 Co-fractionation [4]
16 Co-fractionation [8]
17 Co-fractionation [37]
18 Co-purification [9]
Interacting Protein Name BRG1-associated factor 57 (SMARCE1) Interacting Protein Interacting Protein Info
UniProt ID
SMCE1_HUMAN 
Synonyms BAF57
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [30]
6 Affinity Capture-Western [32]
7 Co-fractionation [37]
8 Co-purification [9]
Interacting Protein Name AT-rich interactive domain-containing protein 1A (ARID1A) Interacting Protein Interacting Protein Info
UniProt ID
ARI1A_HUMAN 
Synonyms B120; BAF250; BAF250a; BM029; C1orf4; ELD; MRD14; OSA1; P270; SMARCF1; hELD; hOSA1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [32]
5 Affinity Capture-Western [33]
6 Affinity Capture-Western [38]
7 Co-purification [9]
Interacting Protein Name Paired amphipathic helix protein Sin3a (SIN3A) Interacting Protein Interacting Protein Info
UniProt ID
SIN3A_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Affinity Capture-Western [49]
3 Affinity Capture-Western [5]
4 Co-purification [16]
Interacting Protein Name Zinc finger protein ubi-d4 (DPF2) Interacting Protein Interacting Protein Info
UniProt ID
REQU_HUMAN 
Synonyms REQ; UBID4; ubi.d4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [6]
3 Co-fractionation [8]
Interacting Target Name Polybromo-1 (PBRM1) Literature-reported Target Interacting Protein Info
UniProt ID
PB1_HUMAN 
Synonyms Protein polybromo-1; Polybromo-1D; PB1; hPB1; BRG1-associated factor 180; BAF180
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [50]
2 Affinity Capture-Western [51]
Interacting Protein Name Non-POU domain-containing octamer-binding protein (NONO) Interacting Protein Interacting Protein Info
UniProt ID
NONO_HUMAN 
Synonyms NMT55; NRB54; P54; P54NRB; PPP1R114
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [3]
References  Top
REF 1 Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. J Biol Chem. 2003 Dec 19;278(51):51638-45.
REF 2 Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15012-7.
REF 3 Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb). Biochem J. 2008 Apr 1;411(1):201-9.
REF 4 Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix. J Cell Biol. 1997 Apr 21;137(2):263-74.
REF 5 mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol. 2003 Nov;23(21):7475-87.
REF 6 Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J Biol Chem. 2010 Jul 16;285(29):21951-60.
REF 7 Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998 Nov 25;95(5):625-36.
REF 8 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 9 Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996 Oct 1;15(19):5370-82.
REF 10 Recruitment of SWI/SNF complex is required for transcriptional activation of the SLC11A1 gene during macrophage differentiation of HL-60 cells. J Biol Chem. 2011 Apr 15;286(15):12839-49.
REF 11 Heterocomplex formation by Arp4 and -actin is involved in the integrity of the Brg1 chromatin remodeling complex. J Cell Sci. 2012 Aug 15;125(Pt 16):3870-82.
REF 12 BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. Mol Cell Biol. 2013 May;33(9):1819-29.
REF 13 BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell. 2000 Jul 21;102(2):257-65.
REF 14 Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors. Biochem J. 2006 Oct 15;399(2):297-304.
REF 15 REST repression of neuronal genes requires components of the hSWI.SNF complex. J Biol Chem. 2002 Oct 25;277(43):41038-45.
REF 16 Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Genes Dev. 2001 Mar 1;15(5):603-18.
REF 17 Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell. 2000 Mar 31;101(1):79-89.
REF 18 Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol. 2004 Nov;24(21):9527-41.
REF 19 Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells. J Cell Sci. 2007 Aug 15;120(Pt 16):2904-11.
REF 20 Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. EMBO J. 2006 Sep 6;25(17):3986-97.
REF 21 A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. EMBO J. 2010 Apr 21;29(8):1434-45.
REF 22 BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation. Acta Biochim Biophys Sin (Shanghai). 2005 Jul;37(7):440-6.
REF 23 Apical role for BRG1 in cytokine-induced promoter assembly. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14611-6.
REF 24 Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J Biol Chem. 2007 May 18;282(20):14992-9.
REF 25 Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Mol Cell Proteomics. 2017 Aug;16(8):1462-1474.
REF 26 Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor tau1 activation domain. Mol Cell Biol. 2000 Mar;20(6):2004-13.
REF 27 Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells. J Biol Chem. 2004 Apr 23;279(17):17319-28.
REF 28 Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. Mol Endocrinol. 2009 Nov;23(11):1776-86.
REF 29 SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem. 2002 Jun 21;277(25):22330-7.
REF 30 BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem. 2008 Nov 21;283(47):32254-63.
REF 31 Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. Hum Mol Genet. 2001 Nov 1;10(23):2651-60.
REF 32 A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005 Dec 1;19(23):2849-61.
REF 33 The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo. Mol Cell Biol. 2008 Feb;28(4):1413-26.
REF 34 BRG1 mutations found in human cancer cell lines inactivate Rb-mediated cell-cycle arrest. J Cell Physiol. 2011 Aug;226(8):1989-97.
REF 35 Mammalian chromatin remodeling complex SWI/SNF is essential for enhanced expression of the albumin gene during liver development. J Biochem. 2006 Feb;139(2):177-88.
REF 36 BAF60a interacts with p53 to recruit the SWI/SNF complex. J Biol Chem. 2008 May 2;283(18):11924-34.
REF 37 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 38 p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes. Mol Cell Biol. 1998 Jun;18(6):3596-603.
REF 39 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 40 BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol. 2002 Mar;22(5):1307-16.
REF 41 Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. EMBO J. 2006 Feb 8;25(3):490-501.
REF 42 MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex. Mol Cell Biol. 2005 May;25(10):3997-4009.
REF 43 Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol. 2002 Sep;22(18):6471-9.
REF 44 Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev. 2000 Oct 1;14(19):2441-51.
REF 45 Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex. EMBO J. 2012 Jan 18;31(2):301-16.
REF 46 The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. J Cell Physiol. 2010 Nov;225(2):569-76.
REF 47 The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem. 2006 Jul 21;281(29):19960-8.
REF 48 Placing the HIRA histone chaperone complex in the chromatin landscape. Cell Rep. 2013 Apr 25;3(4):1012-9.
REF 49 Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Mol Cell Biol. 2002 Feb;22(3):835-48.
REF 50 The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer. J Pathol. 2018 Jan;244(1):36-48.
REF 51 PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev. 2005 Jul 15;19(14):1662-7.

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