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| Protein General Information (TTD Target) |
Top |
| Full Name |
Protein arginine methyltransferase 5 (PRMT5)
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Clinical trial
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Target Info
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| UniProt ID |
ANM5_HUMAN
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| Gene Name |
PRMT5
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| Gene ID |
10419
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| Interacting TTD Target Information |
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| Interacting Successful Target(s) |
Janus kinase 2 (JAK-2) |
Target Info
|
PPI Info
|
[1] |
| Interacting Clinical trial Target(s) |
Protein arginine methyltransferase 5 (PRMT5) |
Target Info
|
PPI Info
|
[2] |
| Interacting Literature-reported Target(s) |
Mitotic growth and transcription activator (BAF190A) |
Target Info
|
PPI Info
|
[3] |
| References |
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| REF 1 |
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell. 2011 Feb 15;19(2):283-94.
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| REF 2 |
Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. J Biol Chem. 2001 Apr 6;276(14):11393-401.
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| REF 3 |
mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol. 2003 Nov;23(21):7475-87.
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