| References |
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| REF 1 |
Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells. J Exp Med. 1995 Dec 1;182(6):1801-6.
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| REF 2 |
Involvement of Janus kinases in the insulin signaling pathway. Eur J Biochem. 1995 Dec 1;234(2):656-60.
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| REF 3 |
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell. 2001 Dec;8(6):1327-38.
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| REF 4 |
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 1993 Jul 30;74(2):227-36.
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| REF 5 |
Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor. J Biol Chem. 1995 Jun 16;270(24):14776-85.
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| REF 6 |
Multimeric growth hormone receptor complexes serve as signaling platforms. J Biol Chem. 2014 Jan 3;289(1):65-73.
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| REF 7 |
SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates. Biochem Biophys Res Commun. 1996 Nov 1;228(1):122-7.
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| REF 8 |
Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. J Biol Chem. 1997 Jan 10;272(2):1032-7.
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| REF 9 |
Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. Blood. 1996 Jun 1;87(11):4495-501.
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| REF 10 |
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem. 2001 Dec 21;276(51):47771-4.
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| REF 11 |
Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling. J Mol Endocrinol. 2005 Apr;34(2):339-51.
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| REF 12 |
ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem. 1999 Jun 11;274(24):17209-18.
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| REF 13 |
Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 9;6(283):ra55.
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| REF 14 |
A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
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| REF 15 |
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell. 2011 Feb 15;19(2):283-94.
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| REF 16 |
The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999 Oct 29;274(44):31531-42.
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| REF 17 |
Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J Biol Chem. 1997 Jul 11;272(28):17694-702.
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| REF 18 |
EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1227-37.
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| REF 19 |
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival. Br J Cancer. 2016 Jul 12;115(2):212-22.
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| REF 20 |
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 1994 Sep 15;13(18):4361-9.
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| REF 21 |
An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene. 1997 Feb 20;14(7):751-61.
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| REF 22 |
Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. Cell Signal. 2010 Aug;22(8):1206-13.
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| REF 23 |
Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):105-12.
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| REF 24 |
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses. Biochem J. 2014 Mar 1;458(2):395-405.
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| REF 25 |
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol. 2002 May;22(10):3316-26.
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| REF 26 |
SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. J Biol Chem. 2003 Dec 26;278(52):52021-31.
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| REF 27 |
The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells. Oncogene. 2001 Feb 15;20(7):849-58.
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| REF 28 |
JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. J Biol Chem. 2009 May 15;284(20):13481-8.
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| REF 29 |
Negative regulation of FAK signaling by SOCS proteins. EMBO J. 2003 Oct 1;22(19):5036-46.
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| REF 30 |
Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun. 1997 Oct 20;239(2):439-46.
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| REF 31 |
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 1999 Mar 1;18(5):1309-20.
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| REF 32 |
A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 1997 Jun 26;387(6636):921-4.
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| REF 33 |
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem. 2000 Sep 22;275(38):29338-47.
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| REF 34 |
Suppressor of cytokine signaling-3 Provides a novel interface in the cross-talk between angiotensin II and insulin signaling systems. Endocrinology. 2005 Feb;146(2):579-88.
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| REF 35 |
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 1999 Jun;4(6):339-51.
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| REF 36 |
Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity. J Biol Chem. 1997 May 30;272(22):14334-40.
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| REF 37 |
Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. EMBO J. 1995 Jan 16;14(2):257-65.
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| REF 38 |
Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J Immunol. 1998 Mar 15;160(6):2742-50.
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| REF 39 |
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J Exp Med. 2001 Jan 15;193(2):263-9.
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| REF 40 |
Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor. Endocrinology. 1998 Mar;139(3):884-93.
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