Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | Erythropoietin Receptor (EPOR) | Successful | Target Info | ||
UniProt ID | EPOR_HUMAN | ||||
Gene Name | EPOR | ||||
Gene ID | 2057 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Janus kinase 2 (JAK-2) | Target Info | PPI Info | [1] | |
Interacting Clinical trial Target(s) | Protein-tyrosine phosphatase SHP-2 (PTPN11) | Target Info | PPI Info | [2] | |
Erythropoietin (EPO) | Target Info | PPI Info | [3] | ||
Interacting Literature-reported Target(s) | Suppressor of cytokine signaling 3 (SOCS3) | Target Info | PPI Info | [4] |
References | Top | ||||
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REF 1 | The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell. 2001 Dec;8(6):1327-38. | ||||
REF 2 | Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. Blood. 1996 Jun 1;87(11):4495-501. | ||||
REF 3 | beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation. Blood. 2007 Jun 15;109(12):5215-22. | ||||
REF 4 | CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem. 2000 Sep 22;275(38):29338-47. |
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