Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T92477 Target Info
Target Name Suppressor of cytokine signaling 3 (SOCS3)
Synonyms STAT-induced STAT inhibitor 3; STAT induced STAT inhibitor 3; SSI3; SSI-3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS3; CIS-3
Target Type Literature-reported Target
Gene Name SOCS3
UniProt ID
SOCS3_HUMAN 
Target Interacting Proteins  Top
Cytokine receptors [+] 1 Cytokine receptors +
Interacting Target Name Erythropoietin Receptor (EPOR) Successful Target Interacting Protein Info
UniProt ID
EPOR_HUMAN 
Synonyms Full-length form; EPO-R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [3]
Kinases [+] 5 Kinases +
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [7]
6 Biochemical Activity [8]
7 Reconstituted Complex [9]
8 Yeast two hybrid [10]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [12]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Far Western [15]
3 Reconstituted Complex [15]
4 Yeast two hybrid [16]
Interacting Target Name Janus kinase 1 (JAK-1) Successful Target Interacting Protein Info
UniProt ID
JAK1_HUMAN 
Synonyms Tyrosine-protein kinase JAK1; JAK1B; JAK1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Biochemical Activity [18]
Interacting Target Name Focal adhesion kinase 2 (PTK2B) Literature-reported Target Interacting Protein Info
UniProt ID
FAK2_HUMAN 
Synonyms Related adhesion focal tyrosine kinase; RAFTK; PYK2; Protein-tyrosine kinase 2-beta; Proline-rich tyrosine kinase 2; FAK2; FADK 2; Cell adhesion kinase beta; Calcium-regulated non-receptor proline-rich tyrosine kinase; Calcium-dependent tyrosine kinase; CAK-beta; CAKB; CADTK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Yeast two hybrid [10]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Elongin-C (ELOC) Interacting Protein Interacting Protein Info
UniProt ID
ELOC_HUMAN 
Synonyms SIII; eloC
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [22]
References  Top
REF 1 CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem. 2000 Sep 22;275(38):29338-47.
REF 2 A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur J Biochem. 2002 May;269(10):2516-26.
REF 3 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem. 2003 Jan 3;278(1):661-71.
REF 4 Suppressor of cytokine signaling-3 Provides a novel interface in the cross-talk between angiotensin II and insulin signaling systems. Endocrinology. 2005 Feb;146(2):579-88.
REF 5 The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells. Oncogene. 2001 Feb 15;20(7):849-58.
REF 6 Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 1999 Jun;4(6):339-51.
REF 7 SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling. Oncogene. 2009 Aug 27;28(34):3069-80.
REF 8 Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates. Growth Factors. 2014 Feb;32(1):1-10.
REF 9 Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity. 2012 Feb 24;36(2):239-50.
REF 10 Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun. 1997 Oct 20;239(2):439-46.
REF 11 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 12 Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J Biol Chem. 2002 Aug 23;277(34):30716-23.
REF 13 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 14 SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov;27(5):811-23.
REF 15 Negative regulation of FAK signaling by SOCS proteins. EMBO J. 2003 Oct 1;22(19):5036-46.
REF 16 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 17 Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Mol Endocrinol. 2000 Mar;14(3):440-8.
REF 18 SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol Cell Biol. 1999 Jul;19(7):4980-8.
REF 19 SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro. BMC Cancer. 2008 May 28;8:150.
REF 20 Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G. FASEB J. 2007 Jan;21(1):217-22.
REF 21 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 2004 Dec 15;18(24):3055-65.
REF 22 Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J Biol Chem. 2003 Aug 22;278(34):31972-9.

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