Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T73184 Target Info
Target Name Histone-lysine N-methyltransferase SETD7 (SETD7)
Synonyms SET9; SET7/9; SET7; SET domain-containing protein 7; Lysine N-methyltransferase 7; KMT7; KIAA1717; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7
Target Type Literature-reported Target
Gene Name SETD7
Biochemical Class Methyltransferase
UniProt ID
SETD7_HUMAN 
Target Interacting Proteins  Top
Histones [+] 1 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 5 Experimental Evidences +
1 Biochemical Activity [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
4 Biochemical Activity [4]
5 Co-crystal Structure [3]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [5]
2 Biochemical Activity [6]
3 Protein-peptide [5]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Interacting Protein Info
UniProt ID
DNMT1_HUMAN 
Synonyms MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [7]
3 Biochemical Activity [8]
4 Co-crystal Structure [8]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [9]
2 Biochemical Activity [3]
3 Co-crystal Structure [3]
4 Yeast two hybrid [10]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [12]
3 Biochemical Activity [11]
4 Biochemical Activity [13]
5 Biochemical Activity [14]
6 Reconstituted Complex [11]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Transcription initiation factor TFIID subunit 10 (TAF10) Interacting Protein Interacting Protein Info
UniProt ID
TAF10_HUMAN 
Synonyms TAF2A; TAF2H; TAFII30
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Biochemical Activity [1]
3 Biochemical Activity [15]
4 Co-crystal Structure [1]
References  Top
REF 1 Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol. 2006 Feb;13(2):140-6.
REF 2 Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell. 2001 Dec;8(6):1207-17.
REF 3 Regulation of p53 activity through lysine methylation. Nature. 2004 Nov 18;432(7015):353-60.
REF 4 Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells. Circ Res. 2012 Apr 13;110(8):1067-76.
REF 5 Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell. 2008 May 9;30(3):336-47.
REF 6 Regulation of estrogen receptor by histone methyltransferase SMYD2-mediated protein methylation. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17284-9.
REF 7 Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5076-81.
REF 8 A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol. 2011 Jan;18(1):42-8.
REF 9 Repression of p53 activity by Smyd2-mediated methylation. Nature. 2006 Nov 30;444(7119):629-32.
REF 10 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 11 Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J. 2009 Apr 22;28(8):1055-66.
REF 12 Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem. 2008 Sep 26;283(39):26771-81.
REF 13 Lysine methylation of the NF-B subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-B signaling. Nat Immunol. 2011 Jan;12(1):29-36.
REF 14 Regulation of NF-kappaB activity through lysine monomethylation of p65. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18972-7.
REF 15 Gene-specific modulation of TAF10 function by SET9-mediated methylation. Mol Cell. 2004 Apr 23;14(2):175-82.

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