Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T86052 Target Info
Target Name Telomerase reverse transcriptase (TERT)
Synonyms Telomerase-associated protein 2; Telomerase catalytic subunit; TRT; TP2; TCS1; HEST2; EST2
Target Type Clinical trial Target
Gene Name TERT
Biochemical Class Kinase
UniProt ID
TERT_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name X-ray repair cross-complementing 5 (Ku80) Literature-reported Target Interacting Protein Info
UniProt ID
XRCC5_HUMAN 
Synonyms X-ray repair cross-complementing protein 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); TLAA; Thyroid-lupus autoantigen; Nuclear factor IV; Lupus Ku autoantigen protein p86; Ku86; G22P2; DNA repair protein XRCC5; CTCBF; CTC85; CTC box-binding factor 85 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase 2 subunit 2; 86 kDa subunit of Ku antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Telomerase-binding protein EST1A (SMG6) Interacting Protein Interacting Protein Info
UniProt ID
EST1A_HUMAN 
Synonyms C17orf31; EST1A; SMG.6; hSMG5/7a
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [3]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
Isomerases [+] 1 Isomerases +
Interacting Protein Name Prostaglandin E synthase 3 (PTGES3) Interacting Protein Interacting Protein Info
UniProt ID
TEBP_HUMAN 
Synonyms P23; TEBP; cPGES
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
3 Yeast two hybrid [6]
Kinases [+] 1 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Fluorescence Resonance Energy Transfer [8]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
References  Top
REF 1 Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem. 2002 Dec 6;277(49):47242-7.
REF 2 The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis. BMC Mol Biol. 2011 Oct 18;12:45.
REF 3 Functional conservation of the telomerase protein Est1p in humans. Curr Biol. 2003 Apr 15;13(8):698-704.
REF 4 CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity. J Biol Chem. 2010 Dec 31;285(53):42033-45.
REF 5 Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem. 2001 May 11;276(19):15571-4.
REF 6 Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 1999 Apr 1;13(7):817-26.
REF 7 Pectenotoxin-2 represses telomerase activity in human leukemia cells through suppression of hTERT gene expression and Akt-dependent hTERT phosphorylation. FEBS Lett. 2008 Oct 15;582(23-24):3263-9.
REF 8 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 9 Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT. Oncogene. 2010 Jul 15;29(28):4101-12.
REF 10 hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation. Gut. 2017 Jan;66(1):31-42.

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