Target Information
Target General Information | Top | |||||
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Target ID |
T11211
(Former ID: TTDS00367)
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Target Name |
Androgen receptor (AR)
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Synonyms |
Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR
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Gene Name |
AR
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Target Type |
Successful target
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[1] | ||||
Disease | [+] 11 Target-related Diseases | + | ||||
1 | Acne vulgaris [ICD-11: ED80] | |||||
2 | Acute myeloid leukaemia [ICD-11: 2A60] | |||||
3 | Alcoholic liver disease [ICD-11: DB94] | |||||
4 | Breast cancer [ICD-11: 2C60-2C6Y] | |||||
5 | Chronic obstructive pulmonary disease [ICD-11: CA22] | |||||
6 | Female pelvic pain [ICD-11: GA34] | |||||
7 | Hypo-osmolality/hyponatraemia [ICD-11: 5C72] | |||||
8 | Low bone mass disorder [ICD-11: FB83] | |||||
9 | Mammary tumour [ICD-11: 2C60-2C6Z] | |||||
10 | Prostate cancer [ICD-11: 2C82] | |||||
11 | Testicular dysfunction [ICD-11: 5A81] | |||||
Function |
Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Click to Show/Hide
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BioChemical Class |
Nuclear hormone receptor
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UniProt ID | ||||||
Sequence |
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQ SALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSAD LKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELC KAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAG KSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQ SRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAA GPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAP YGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRL ETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRN DCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKL TVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSR MYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELD RIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEII SVQVPKILSGKVKPIYFHTQ Click to Show/Hide
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3D Structure | Click to Show 3D Structure of This Target | AlphaFold | ||||
ADReCS ID | BADD_A01831 | |||||
HIT2.0 ID | T20JZ2 |
Drugs and Modes of Action | Top | |||||
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Approved Drug(s) | [+] 19 Approved Drugs | + | ||||
1 | ARN-509 | Drug Info | Approved | Acute myeloid leukaemia | [2] | |
2 | Bicalutamide | Drug Info | Approved | Prostate cancer | [3], [4] | |
3 | Clascoterone | Drug Info | Approved | Acne vulgaris | [5] | |
4 | Cyproterone | Drug Info | Approved | Prostate cancer | [6] | |
5 | Darolutamide | Drug Info | Approved | Prostate cancer | [7] | |
6 | Dromostanolone | Drug Info | Approved | Mammary tumour | [4], [8] | |
7 | Enzalutamide | Drug Info | Approved | Prostate cancer | [9] | |
8 | Ethylestrenol | Drug Info | Approved | Testosterone deficiency | [10] | |
9 | Fludrocortisone | Drug Info | Approved | Cerebral salt-wasting syndrome | [11], [12] | |
10 | Flufenamic Acid | Drug Info | Approved | Dysmenorrhea | [10], [13] | |
11 | Fluoxymesterone | Drug Info | Approved | Breast cancer | [4], [10], [14] | |
12 | Flutamide | Drug Info | Approved | Prostate cancer | [15], [16] | |
13 | Hydroxyflutamide | Drug Info | Approved | Prostate cancer | [17], [18] | |
14 | Nandrolone | Drug Info | Approved | Osteoporosis | [19], [4] | |
15 | Nilutamide | Drug Info | Approved | Prostate cancer | [20], [18] | |
16 | Oxandrolone | Drug Info | Approved | Alcoholic hepatitis | [21], [22] | |
17 | Prasterone | Drug Info | Approved | Chronic obstructive pulmonary disease | [23] | |
18 | Testosterone | Drug Info | Approved | Osteoporosis | [24], [25] | |
19 | Dihydrotestosterone | Drug Info | Phase 4 | Prostate hyperplasia | [26], [27] | |
Clinical Trial Drug(s) | [+] 21 Clinical Trial Drugs | + | ||||
1 | HC-1119 | Drug Info | Phase 3 | Prostate cancer | [28] | |
2 | ZANOTERONE | Drug Info | Phase 3 | Prostate hyperplasia | [29] | |
3 | ASC-J9 | Drug Info | Phase 2 | Thrombosis | [30] | |
4 | ASCJ-9 | Drug Info | Phase 2 | Alopecia | [31] | |
5 | AZD5312 | Drug Info | Phase 2 | Prostate cancer | [32] | |
6 | MK-0773 | Drug Info | Phase 2 | Osteoporosis | [33] | |
7 | Testogen TDS | Drug Info | Phase 2 | Hypogonadism | [34] | |
8 | TOK-001 | Drug Info | Phase 2 | Prostate cancer | [35], [36] | |
9 | APC-100 | Drug Info | Phase 1/2 | Prostate cancer | [37] | |
10 | ARV-110 | Drug Info | Phase 1/2 | Prostate cancer | [38] | |
11 | ARV-471 | Drug Info | Phase 1/2 | Breast cancer | [39] | |
12 | ONC1-13B | Drug Info | Phase 1/2 | Prostate cancer | [40] | |
13 | AZD-3514 | Drug Info | Phase 1 | Prostate cancer | [41] | |
14 | CC-94676 | Drug Info | Phase 1 | Prostate cancer | [42] | |
15 | Drug 2881078 | Drug Info | Phase 1 | Heart failure | [43] | |
16 | DT-200 | Drug Info | Phase 1 | Duchenne dystrophy | [44] | |
17 | EPI-7386 | Drug Info | Phase 1 | Prostate cancer | [45] | |
18 | PS-178990 | Drug Info | Phase 1 | Muscle atrophy | [46] | |
19 | RAD-140 | Drug Info | Phase 1 | Breast cancer | [32] | |
20 | TAS3681 | Drug Info | Phase 1 | Prostate cancer | [32] | |
21 | TESTOSTERONE BUCICLATE | Drug Info | Phase 1 | Contraception | [47] | |
Discontinued Drug(s) | [+] 11 Discontinued Drugs | + | ||||
1 | GW-275919 | Drug Info | Discontinued in Phase 2 | Pain | [48] | |
2 | HE-2000 | Drug Info | Discontinued in Phase 2 | Cystic fibrosis | [49] | |
3 | NP-619 | Drug Info | Discontinued in Phase 2 | Alopecia | [50] | |
4 | Testosterone glucoside | Drug Info | Discontinued in Phase 2 | Hypogonadism | [51] | |
5 | GSK2849466 | Drug Info | Discontinued in Phase 1 | Heart failure | [52] | |
6 | LGD2941 | Drug Info | Discontinued in Phase 1 | Osteoporosis | [53] | |
7 | MX-4509 | Drug Info | Discontinued in Phase 1 | Neurological disorder | [54] | |
8 | Opterone | Drug Info | Discontinued in Phase 1 | Hormone deficiency | [55] | |
9 | PF-06260414 | Drug Info | Discontinued in Phase 1 | Cachexia | [56] | |
10 | LG-2293 | Drug Info | Terminated | Prostate cancer | [58] | |
11 | ZD-3980 | Drug Info | Terminated | Prostate hyperplasia | [59] | |
Preclinical Drug(s) | [+] 1 Preclinical Drugs | + | ||||
1 | GLPG-0492 | Drug Info | Preclinical | Cachexia | [57] | |
Mode of Action | [+] 7 Modes of Action | + | ||||
Inhibitor | [+] 22 Inhibitor drugs | + | ||||
1 | ARN-509 | Drug Info | [2] | |||
2 | Fludrocortisone | Drug Info | [65] | |||
3 | Flufenamic Acid | Drug Info | [66] | |||
4 | HC-1119 | Drug Info | [78] | |||
5 | ZANOTERONE | Drug Info | [79] | |||
6 | ASC-J9 | Drug Info | [80] | |||
7 | TOK-001 | Drug Info | [35] | |||
8 | APC-100 | Drug Info | [37] | |||
9 | EPI-7386 | Drug Info | [90] | |||
10 | HE-2000 | Drug Info | [93] | |||
11 | Opterone | Drug Info | [84] | |||
12 | 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane | Drug Info | [101] | |||
13 | 11-methyl-6,11-dihydro-5H-benzo[a]carbazol-9-ol | Drug Info | [102] | |||
14 | 6,11-dihydrothiochromeno[4,3-b]indol-8-ol | Drug Info | [102] | |||
15 | Calusterone | Drug Info | [105] | |||
16 | OXENDLONE | Drug Info | [110] | |||
17 | Palodesangren C | Drug Info | [110] | |||
18 | Palodesangren D | Drug Info | [110] | |||
19 | Palodesangren E | Drug Info | [110] | |||
20 | RU-59063 | Drug Info | [111] | |||
21 | [3H]methyltrienolone | Drug Info | [104] | |||
22 | [3H]mibolerone | Drug Info | [111] | |||
Antagonist | [+] 18 Antagonist drugs | + | ||||
1 | Bicalutamide | Drug Info | [1], [60] | |||
2 | Clascoterone | Drug Info | [5] | |||
3 | Cyproterone | Drug Info | [61] | |||
4 | Darolutamide | Drug Info | [7] | |||
5 | Flutamide | Drug Info | [1] | |||
6 | Hydroxyflutamide | Drug Info | [18], [69], [70] | |||
7 | Nilutamide | Drug Info | [72] | |||
8 | Prasterone | Drug Info | [74] | |||
9 | ONC1-13B | Drug Info | [87] | |||
10 | AZD-3514 | Drug Info | [88] | |||
11 | TAS3681 | Drug Info | [32] | |||
12 | MX-4509 | Drug Info | [70] | |||
13 | ARN34 | Drug Info | [69] | |||
14 | ASC-JMX2 | Drug Info | [103] | |||
15 | CH-4933468 | Drug Info | [103] | |||
16 | DL-3 | Drug Info | [103] | |||
17 | HYG-440 | Drug Info | [109] | |||
18 | SX-ARPC | Drug Info | [112] | |||
Binder | [+] 2 Binder drugs | + | ||||
1 | Dromostanolone | Drug Info | [62], [63] | |||
2 | PS-178990 | Drug Info | [91] | |||
Modulator | [+] 22 Modulator drugs | + | ||||
1 | Enzalutamide | Drug Info | [10] | |||
2 | Ethylestrenol | Drug Info | [64] | |||
3 | Dihydrotestosterone | Drug Info | [77] | |||
4 | AZD5312 | Drug Info | [82] | |||
5 | MK-0773 | Drug Info | [83] | |||
6 | Testogen TDS | Drug Info | [84] | |||
7 | Drug 2881078 | Drug Info | [89] | |||
8 | DT-200 | Drug Info | [44] | |||
9 | RAD-140 | Drug Info | [92] | |||
10 | GW-275919 | Drug Info | [48] | |||
11 | NP-619 | Drug Info | [94] | |||
12 | GSK2849466 | Drug Info | [95] | |||
13 | LGD2941 | Drug Info | [96] | |||
14 | PF-06260414 | Drug Info | [97] | |||
15 | GLPG-0492 | Drug Info | [98] | |||
16 | LG-2293 | Drug Info | [99] | |||
17 | ZD-3980 | Drug Info | [100] | |||
18 | Andromustine | Drug Info | [103] | |||
19 | ASC-JMZ1 | Drug Info | [103] | |||
20 | EPI-001 | Drug Info | [107] | |||
21 | GTx-027 | Drug Info | [108] | |||
22 | SARMs | Drug Info | [103] | |||
Agonist | [+] 9 Agonist drugs | + | ||||
1 | Fluoxymesterone | Drug Info | [67], [68] | |||
2 | Nandrolone | Drug Info | [71] | |||
3 | Oxandrolone | Drug Info | [73] | |||
4 | Testosterone | Drug Info | [75], [76] | |||
5 | TESTOSTERONE BUCICLATE | Drug Info | [84] | |||
6 | Testosterone glucoside | Drug Info | [84] | |||
7 | Boldenone | Drug Info | [104] | |||
8 | Delta1-dihydrotestosterone | Drug Info | [106] | |||
9 | Testetrol | Drug Info | [113] | |||
Enhancer | [+] 1 Enhancer drugs | + | ||||
1 | ASCJ-9 | Drug Info | [81] | |||
Degrader | [+] 3 Degrader drugs | + | ||||
1 | ARV-110 | Drug Info | [85] | |||
2 | ARV-471 | Drug Info | [86] | |||
3 | CC-94676 | Drug Info | [42] |
Chemical Structure based Activity Landscape of Target | Top |
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Drug Property Profile of Target | Top | |
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(1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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(3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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(5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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"RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five |
Co-Targets | Top | |||||
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Co-Targets |
Target Poor or Non Binders | Top | |||||
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Target Poor or Non Binders |
Target Regulators | Top | |||||
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Target-regulating microRNAs | ||||||
Target-interacting Proteins |
Target Profiles in Patients | Top | |||||
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Target Expression Profile (TEP) | ||||||
Drug Resistance Mutation (DRM) |
Target Affiliated Biological Pathways | Top | |||||
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KEGG Pathway | [+] 3 KEGG Pathways | + | ||||
1 | Oocyte meiosis | |||||
2 | Pathways in cancer | |||||
3 | Prostate cancer | |||||
NetPath Pathway | [+] 3 NetPath Pathways | + | ||||
1 | EGFR1 Signaling Pathway | |||||
2 | AndrogenReceptor Signaling Pathway | |||||
3 | FSH Signaling Pathway | |||||
PID Pathway | [+] 7 PID Pathways | + | ||||
1 | Regulation of nuclear SMAD2/3 signaling | |||||
2 | Coregulation of Androgen receptor activity | |||||
3 | Regulation of Androgen receptor activity | |||||
4 | Nongenotropic Androgen signaling | |||||
5 | Regulation of nuclear beta catenin signaling and target gene transcription | |||||
6 | FOXA1 transcription factor network | |||||
7 | Notch-mediated HES/HEY network | |||||
Reactome | [+] 2 Reactome Pathways | + | ||||
1 | Nuclear Receptor transcription pathway | |||||
2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | |||||
WikiPathways | [+] 6 WikiPathways | + | ||||
1 | SIDS Susceptibility Pathways | |||||
2 | Integrated Pancreatic Cancer Pathway | |||||
3 | Prostate Cancer | |||||
4 | Integrated Breast Cancer Pathway | |||||
5 | Nuclear Receptors | |||||
6 | Androgen receptor signaling pathway |
Target-Related Models and Studies | Top | |||||
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Target Validation |
References | Top | |||||
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REF 1 | Androgen receptor as a target in androgen-independent prostate cancer. Urology. 2002 Sep;60(3 Suppl 1):132-8; discussion 138-9. | |||||
REF 2 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||||
REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2863). | |||||
REF 4 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||||
REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 | |||||
REF 6 | Drug information of Cyproterone, 2008. eduDrugs. | |||||
REF 7 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 | |||||
REF 8 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6947). | |||||
REF 9 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||||
REF 10 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
REF 11 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2873). | |||||
REF 12 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010060. | |||||
REF 13 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2447). | |||||
REF 14 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2861). | |||||
REF 15 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6943). | |||||
REF 16 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075298. | |||||
REF 17 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2862). | |||||
REF 18 | Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol. 2007 Apr;4(4):236-44. | |||||
REF 19 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6949). | |||||
REF 20 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2864). | |||||
REF 21 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7092). | |||||
REF 22 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076761. | |||||
REF 23 | Direct agonist/antagonist functions of dehydroepiandrosterone. Endocrinology. 2005 Nov;146(11):4568-76. | |||||
REF 24 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2858). | |||||
REF 25 | Emerging drugs for hypogonadism. Expert Opin Emerg Drugs. 2006 Nov;11(4):685-707. | |||||
REF 26 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2856). | |||||
REF 27 | ClinicalTrials.gov (NCT00062790) Effect Of Dutasteride On Intraprostatic Dihydrotestosterone (DHT) Levels. U.S. National Institutes of Health. | |||||
REF 28 | ClinicalTrials.gov (NCT03850795) HC-1119 Versus Enzalutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC). U.S. National Institutes of Health. | |||||
REF 29 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002570) | |||||
REF 30 | ClinicalTrials.gov (NCT03612856) Safety and Efficacy Study of AB023 (Xisomab 3G3) in End Stage Renal Disease Patients on Chronic Hemodialysis. U.S. National Institutes of Health. | |||||
REF 31 | ClinicalTrials.gov (NCT01289574) Topical ASC-J9 Cream for Acne. U.S. National Institutes of Health. | |||||
REF 32 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
REF 33 | ClinicalTrials.gov (NCT00529659) A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005). U.S. National Institutes of Health. | |||||
REF 34 | ClinicalTrials.gov (NCT01894308) A Dose Ranging Study to Examine Testagen TDS-Testosterone 5%. U.S. National Institutes of Health. | |||||
REF 35 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8638). | |||||
REF 36 | Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor. Clin Cancer Res. 2014 Aug 1;20(15):4075-85. | |||||
REF 37 | 2011 Pipeline of Adamis Pharmaceuticals. | |||||
REF 38 | ClinicalTrials.gov (NCT03888612) Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC). U.S. National Institutes of Health. | |||||
REF 39 | ClinicalTrials.gov (NCT04072952) A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer (mBC). U.S. National Institutes of Health. | |||||
REF 40 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039208) | |||||
REF 41 | ClinicalTrials.gov (NCT01351688) An Open Label Prostate Cancer Study in Japanese Patients. U.S. National Institutes of Health. | |||||
REF 42 | ClinicalTrials.gov (NCT04428788) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CC-94676 in Subjects With Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health. | |||||
REF 43 | ClinicalTrials.gov (NCT02567773) Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078. | |||||
REF 44 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
REF 45 | ClinicalTrials.gov (NCT04421222) Oral EPI-7386 in Patients With Metastatic Castration-Resistant Prostate Cancer (EPI-7386). U.S. National Institutes of Health. | |||||
REF 46 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027228) | |||||
REF 47 | Testosterone buciclate (20 Aet-1) in hypogonadal men: pharmacokinetics and pharmacodynamics of the new long-acting androgen ester. J Clin Endocrinol Metab. 1992 Nov;75(5):1204-10. | |||||
REF 48 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010426) | |||||
REF 49 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010830) | |||||
REF 50 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028305) | |||||
REF 51 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018266) | |||||
REF 52 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036899) | |||||
REF 53 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013541) | |||||
REF 54 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020680) | |||||
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