Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T56051 Target Info
Target Name Ubiquitin thioesterase L1 (UCHL1)
Synonyms Ubiquitin thiolesterase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin carboxy-terminal hydrolase L1; UCH-L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
Target Type Preclinical Target
Gene Name UCHL1
Biochemical Class Peptidase
UniProt ID
UCHL1_HUMAN 
Target Interacting Proteins  Top
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Kinases [+] 1 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [4]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 9 Experimental Evidences +
1 Biochemical Activity [5]
2 Biochemical Activity [6]
3 Biochemical Activity [7]
4 Biochemical Activity [8]
5 Biochemical Activity [9]
6 Biochemical Activity [10]
7 Co-crystal Structure [11]
8 Reconstituted Complex [11]
9 Reconstituted Complex [9]
References  Top
REF 1 Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem. 2008 Aug 29;283(35):23731-8.
REF 2 Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy. Autophagy. 2008 Aug;4(6):827-9.
REF 3 Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem. 2005 Sep 9;280(36):31870-81.
REF 4 Systematic identification of molecular links between core and candidate genes in breast cancer. J Mol Biol. 2015 Mar 27;427(6 Pt B):1436-1450.
REF 5 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
REF 6 Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases. FEBS J. 2012 Mar;279(6):1106-18.
REF 7 Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry. 1998 Mar 10;37(10):3358-68.
REF 8 Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.
REF 9 Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome. Sci Rep. 2017 Mar 24;7:45174.
REF 10 Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. Biochemistry. 2016 Aug 23;55(33):4708-19.
REF 11 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9117-22.

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