Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Extracellular signal-regulated kinase 1 (ERK1) | Clinical trial | Target Info | ||
UniProt ID | MK03_HUMAN | ||||
Gene Name | MAPK3 | ||||
Gene ID | 5595 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Clinical trial Target(s) | ERK activator kinase 1 (MEK1) | Target Info | PPI Info | [1] | |
ERK activator kinase 2 (MEK2) | Target Info | PPI Info | [1] | ||
Extracellular signal-regulated kinase 2 (ERK2) | Target Info | PPI Info | [2] | ||
Stress-activated protein kinase 2a (p38 alpha) | Target Info | PPI Info | [3] | ||
Dual specificity protein phosphatase 1 (DUSP1) | Target Info | PPI Info | [4] | ||
Extracellular signal-regulated kinase 1 (ERK1) | Target Info | PPI Info | [5] | ||
Interacting Literature-reported Target(s) | Ribosomal protein S6 kinase alpha-2 (RSK2) | Target Info | PPI Info | [6] | |
Deoxyhypusine synthase (DHPS) | Target Info | PPI Info | [7] |
References | Top | ||||
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REF 1 | Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. J Biol Chem. 1996 Feb 23;271(8):4230-5. | ||||
REF 2 | Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44. | ||||
REF 3 | p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels. Mol Cell Biol. 2003 May;23(9):3079-90. | ||||
REF 4 | Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science. 1999 Dec 24;286(5449):2514-7. | ||||
REF 5 | A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells. PLoS One. 2009 Oct 22;4(10):e7541. | ||||
REF 6 | The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20. | ||||
REF 7 | Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2014 Apr 11;5:3650. |
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