Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T28025 Target Info
Target Name Proto-oncogene c-Fos (c-Fos)
Synonyms G0S7; G0/G1 switch regulatory protein 7; Cellular oncogene fos; C-fos
Target Type Literature-reported Target
Gene Name FOS
Biochemical Class Basic leucine zipper bZIP
UniProt ID
FOS_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Cyclic AMP-dependent transcription factor ATF-2 (ATF2) Interacting Protein Interacting Protein Info
UniProt ID
ATF2_HUMAN 
Synonyms CRE.BP1; CREB.2; CREB2; HB16; TREB7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Fluorescence Resonance Energy Transfer [4]
5 Reconstituted Complex [5]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
3 Reconstituted Complex [6]
4 Yeast two hybrid [7]
Transcription regulators [+] 7 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [3]
5 Affinity Capture-Western [9]
6 Affinity Capture-Western [10]
7 Affinity Capture-Western [11]
8 Affinity Capture-Western [12]
9 Co-fractionation [12]
10 Co-localization [13]
11 Co-localization [12]
12 Fluorescence Resonance Energy Transfer [10]
13 Reconstituted Complex [14]
14 Reconstituted Complex [5]
15 Reconstituted Complex [15]
16 Reconstituted Complex [16]
17 Reconstituted Complex [17]
18 Reconstituted Complex [18]
19 Reconstituted Complex [19]
20 Yeast two hybrid [20]
Interacting Protein Name Transcription factor jun-D (JUND) Interacting Protein Interacting Protein Info
UniProt ID
JUND_HUMAN 
Synonyms AP.1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [3]
5 Affinity Capture-Western [21]
6 Reconstituted Complex [5]
Interacting Protein Name Transcription factor jun-B (JUNB) Interacting Protein Interacting Protein Info
UniProt ID
JUNB_HUMAN 
Synonyms AP.1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [8]
4 Affinity Capture-MS [3]
5 Fluorescence Resonance Energy Transfer [4]
6 Yeast two hybrid [22]
Interacting Target Name Runt-related transcription factor 2 (RUNX2) Literature-reported Target Interacting Protein Info
UniProt ID
RUNX2_HUMAN 
Synonyms SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha Asubunit; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEBP2A; PEA2-alpha A; Osteoblast-specific transcription factor 2; OSF-2; OSF2; Oncogene AML-3; Core-binding factor subunit alpha-1; CBF-alpha-1; CBFA1; AML3; Acute myeloid leukemia 3 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Reconstituted Complex [23]
3 Yeast two hybrid [24]
Interacting Protein Name Cyclic AMP-responsive element-binding protein 5 (CREB5) Interacting Protein Interacting Protein Info
UniProt ID
CREB5_HUMAN 
Synonyms CRE.BPA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Yeast two hybrid [22]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [25]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [26]
2 Fluorescence Resonance Energy Transfer [4]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Centromere protein O (CENPO) Interacting Protein Interacting Protein Info
UniProt ID
CENPO_HUMAN 
Synonyms CENP.O; ICEN.36; MCM21R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [22]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 4 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4.
REF 5 A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One. 2010 Feb 24;5(2):e9289.
REF 6 Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes. FASEB J. 2008 Sep;22(9):3337-47.
REF 7 Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. J Biol Chem. 1998 Jul 3;273(27):16651-4.
REF 8 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 9 Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. J Biol Chem. 2010 Jun 25;285(26):20343-57.
REF 10 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 11 Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol Cell Biol. 2005 Aug;25(16):6964-79.
REF 12 c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics. Mol Cell Biol. 2010 Aug;30(15):3767-78.
REF 13 Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24.
REF 14 Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. J Biol Chem. 2001 Jan 26;276(4):2852-7.
REF 15 Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene. 1998 Dec 17;17(24):3145-56.
REF 16 Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2. J Biol Chem. 2005 Sep 23;280(38):32569-77.
REF 17 Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol Cancer Ther. 2006 Aug;5(8):2034-42.
REF 18 Characterization of a c-Jun-responsive module in the 5'-flank of the human CYP2J2 gene that regulates transactivation. Biochem J. 2005 Nov 1;391(Pt 3):631-40.
REF 19 Thioredoxin-1 and its natural inhibitor, vitamin D3 up-regulated protein 1, are differentially regulated by PPARalpha in human macrophages. J Mol Biol. 2008 Dec 19;384(3):564-76.
REF 20 Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. Oncogene. 1997 May 1;14(17):2091-8.
REF 21 Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA. J Biol Chem. 2001 Aug 24;276(34):32362-72.
REF 22 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 23 AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem. 2001 Jun 8;276(23):20029-38.
REF 24 Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem. 2002 Jan 4;277(1):816-22.
REF 25 p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res. 2002 Jan 1;62(1):141-51.
REF 26 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.

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