Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | Activating transcription factor 4 (ATF-4) | Literature-reported | Target Info | ||
UniProt ID | ATF4_HUMAN | ||||
Gene Name | ATF4 | ||||
Gene ID | 468 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Clinical trial Target(s) | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [1] | |
CREB-binding protein (CREBBP) | Target Info | PPI Info | [2] | ||
Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [4] | ||
Interacting Discontinued Target(s) | Transcription factor AP-1 (JUN) | Target Info | PPI Info | [3] | |
Interacting Literature-reported Target(s) | Proto-oncogene c-Fos (c-Fos) | Target Info | PPI Info | [3] | |
Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) | Target Info | PPI Info | [5] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. Mol Cell. 2016 Jun 16;62(6):890-902. | ||||
REF 2 | Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein. J Biol Chem. 1997 Sep 19;272(38):24088-95. | ||||
REF 3 | Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4. | ||||
REF 4 | p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J Biol Chem. 2005 Dec 16;280(50):41537-45. | ||||
REF 5 | ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2200-5. |
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