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| Protein General Information (TTD Target) |
Top |
| Full Name |
Nuclear factor erythroid 2-related factor 2 (Nrf2)
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Successful
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Target Info
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| UniProt ID |
NF2L2_HUMAN
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| Gene Name |
NFE2L2
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| Gene ID |
4780
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| Interacting TTD Target Information |
Top |
| Interacting Clinical trial Target(s) |
CREB-binding protein (CREBBP) |
Target Info
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PPI Info
|
[1] |
| Interacting Discontinued Target(s) |
Transcription factor AP-1 (JUN) |
Target Info
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PPI Info
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[2] |
| References |
Top |
| REF 1 |
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta. 2008 May;1783(5):713-27.
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| REF 2 |
Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene. 1998 Dec 17;17(24):3145-56.
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