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| Protein General Information |
Top |
| Full Name |
Tuberin (TSC2)
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| UniProt ID |
TSC2_HUMAN
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| Gene Name |
TSC2
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| Gene ID |
7249
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| Interacting TTD Target Information |
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| Interacting Successful Target(s) |
Estrogen receptor (ESR) |
Target Info
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PPI Info
|
[1] |
| Interacting Clinical trial Target(s) |
Glycogen synthase kinase-3 beta (GSK-3B) |
Target Info
|
PPI Info
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[2] |
| Interacting Patented-recorded Target(s) |
Ribosomal protein S6 kinase alpha-1 (RSK1) |
Target Info
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PPI Info
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[3] |
| References |
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| REF 1 |
Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2. J Biol Chem. 2004 May 28;279(22):23114-22.
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| REF 2 |
The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J Biol Chem. 2003 Feb 21;278(8):5947-51.
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| REF 3 |
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94.
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