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Protein General Information |
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Full Name |
Ubiquitin carboxyl-terminal hydrolase 22 (USP22)
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UniProt ID |
UBP22_HUMAN
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Gene Name |
USP22
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Gene ID |
23326
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Interacting TTD Target Information |
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Interacting Clinical trial Target(s) |
NAD-dependent deacetylase sirtuin-1 (SIRT1) |
Target Info
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PPI Info
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[1] |
Interacting Literature-reported Target(s) |
Proto-oncogene c-Myc (MYC) |
Target Info
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PPI Info
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[2] |
References |
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REF 1 |
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol. 2013 Apr;33(8):1487-502.
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REF 2 |
Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells. J Cell Physiol. 2017 Dec;232(12):3664-3676.
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