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| Protein General Information (TTD Target) |
Top |
| Full Name |
Vascular endothelial growth factor receptor 1 (FLT-1)
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Successful
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Target Info
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| UniProt ID |
VGFR1_HUMAN
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| Gene Name |
FLT1
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| Gene ID |
2321
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| References |
Top |
| REF 1 |
N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain. PLoS One. 2014 Nov 11;9(11):e112794.
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| REF 2 |
Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells. Cell Signal. 2012 Jan;24(1):214-23.
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| REF 3 |
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11709-14.
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