Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02001 | Target Info | |||
| Target Name | Phosphodiesterase 4D (PDE4D) | ||||
| Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D; PDE43; DPDE3
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| Target Type | Successful Target | ||||
| Gene Name | PDE4D | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 74 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CI-930
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|
Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
CI-930; CI 930; 86798-59-6; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-5-methyl-; AC1MIBTH; CHEMBL440593; SCHEMBL6052113; CTK5F7194; BDBM14362; AEZZPAQOEUQNBB-UHFFFAOYSA-N; 90791-23-4 (hydrochloride); BDBM50225945; LS-187480; LS-186812; 6-[4-(1-Imidazolyl)phenyl]-5-methyl-3-oxo-2,3,4,5-tetrahydropyridazine; 3-(4-imidazol-1-ylphenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(R)-DULOXETINE
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|
Investigative | Compound Info | ||
| Synonyms |
(R)-duloxetine; Duloxetine, (R)-; 116539-60-7; UNII-TK9VOT90JQ; R-Duloxetine HCl; TK9VOT90JQ; CHEMBL336920; CHEBI:36797; (3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; (3R)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine; Duloxetine impurity A; Ariclaim; Duloxetine hydrochloride impurity A [EP]; Duloxetine hydrochloride specified impurity A [EP]; SCHEMBL1200511; (r)-n-methyl-3-(1-naphthoxy)-3-(2-thienyl)propylamine; DTXSID40151424; ZINC1536780; PDSP1_000970
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-Norfluoxetine
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|
Investigative | Compound Info | ||
| Synonyms |
126924-38-7; SEPROXETINE; UNII-25CO3X0R31; (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE; CHEMBL465123; (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine; 25CO3X0R31; (S)-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine; Seproxetine [INN]; S-Norfluoxetine; AC1MHW5Z; SCHEMBL272873; ZINC4531; CTK8E9555; MolPort-005-941-621; 9173AH; BDBM50254790; AKOS027384574; DB06731; AJ-08214; RT-014029; FT-0673089; NFL_296.1257_14.5; J-005451
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(S)-NORDULOXETINE
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595063; (S)-NORDULOXETINE; SCHEMBL4573573; ZINC34220632; BDBM50304388; (S)-gamma-(1-Naphthyloxy)-2-thiophenepropan-1-amine
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
R-NORDULOXETINE
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594585; R-NORDULOXETINE; BDBM50304393
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434332
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4167151
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466933
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| Activity |
IC50 = 50100 nM
|
[4] | |||
| Compound Name |
(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyridazin-4-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090405; BDBM50314582
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|
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| Activity |
Ki = 51200 nM
|
[5] | |||
| Compound Name |
Chembl4281168
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466917
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|
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| Activity |
IC50 = 52900 nM
|
[6] | |||
| Compound Name |
8-Chloro-5-[2-(methylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184979; BDBM50151642
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|
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| Activity |
IC50 = 53200 nM
|
[7] | |||
| Compound Name |
N-(3-(4-(Pyrimidin-2-yl)piperazin-1-yl)propyl)-4-m-tolylpyridazino[4,5-b]indolizin-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091807; BDBM50314559
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|
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| Activity |
Ki = 54400 nM
|
[5] | |||
| Compound Name |
8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184013; BDBM50151632
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|
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| Activity |
IC50 = 55000 nM
|
[7] | |||
| Compound Name |
Chembl4164011
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466946
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|
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| Activity |
IC50 = 56800 nM
|
[4] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-cyclohexyl-3-methyl-1,3,4-thiadiazol-2-imine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184334; SCHEMBL4249845; SCHEMBL4249847; BDBM50151541; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-cyclohexyl-amine
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|
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| Activity |
IC50 = 57000 nM
|
[8] | |||
| Compound Name |
2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]-3-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184837; BDBM50151540; 2-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-3-hydroxy-benzoic acid
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| Activity |
IC50 = 58250 nM
|
[8] | |||
| Compound Name |
4-Phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propyl)pyridazino[4,5-b]indolizin-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091451; BDBM50314556
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|
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| Activity |
Ki = 59000 nM
|
[5] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL509969; BDBM50273985
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|
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| Activity |
IC50 = 60000 nM
|
[9] | |||
| Compound Name |
Cyclopentyl(4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090031; BDBM50314567
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|
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| Activity |
Ki = 61000 nM
|
[5] | |||
| Compound Name |
(4-(3-(4-(3-Fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)(1-methyl-1H-pyrrol-2-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094023; BDBM50314569
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|
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| Activity |
Ki = 65000 nM
|
[5] | |||
| Compound Name |
(3,4,5-Trimethoxyphenyl)methyl 5-phenylfuran-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2041596; BDBM50385902
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|
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| Activity |
IC50 = 66300 nM
|
[10] | |||
| Compound Name |
7-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-pyridin-3-ylpyrazolo[1,5-a]pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604519; SCHEMBL8216562; BDBM50310204; 7-(3''-Cyclopropylmethoxy-4''-difluoromethoxyphenyl)-2-pyridin-3-yl-pyrazolo[1,5-a]pyrimidine
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|
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| Activity |
EC50 = 66900 nM
|
[11] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pentan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447757; BDBM50273987
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|
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| Activity |
IC50 = 70794.58 nM
|
[9] | |||
| Compound Name |
2-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361706; SCHEMBL4246658; BDBM50151551
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|
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| Activity |
IC50 = 71000 nM
|
[8] | |||
| Compound Name |
Chembl4172684
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|
Investigative | Compound Info | ||
| Synonyms |
ZINC3446649; BDBM50466939; AKOS034023985; MCULE-2053837401; Z27692369; 1-[5-(4-nitrophenyl)furan-2-carbonyl]-1,2,3,4-tetrahydroquinoline; (3,4-Dihydroquinolin-1(2H)-yl)(5-(4-nitrophenyl)furan-2-yl)methanone
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|
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| Activity |
IC50 = 77200 nM
|
[4] | |||
| Compound Name |
N-(1-Azabicyclo[2.2.1]heptan-3-yl)-5-(4-chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185502; BDBM50151548
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|
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| Activity |
IC50 = 79000 nM
|
[8] | |||
| Compound Name |
4-(4-Hydroxy-3-methoxyphenyl]-4-pyridin-3-ylbutan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457217; BDBM50273602
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|
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| Activity |
IC50 = 79432.82 nM
|
[9] | |||
| Compound Name |
(4-(3-(7-(3-Chlorophenyl)-1,2-dimethyl-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093094; BDBM50314573
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|
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| Activity |
Ki = 80900 nM
|
[5] | |||
| Compound Name |
Chembl4160331
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466938
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|
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| Activity |
IC50 = 81300 nM
|
[4] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-cyclopentyl-3-methyl-1,3,4-thiadiazol-2-imine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182788; SCHEMBL4246722; SCHEMBL4246727; BDBM50151582; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-cyclopentyl-amine
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| Activity |
IC50 = 81500 nM
|
[8] | |||
| Compound Name |
Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
ETHYL 3,5-DIMETHYL-1H-4-PYRAZOLECARBOXYLATE; ethyl 3,5-dimethylpyrazole-4-carboxylate; 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER; 4-Pyrazolecarboxylic acid, 3,5-dimethyl-, ethyl ester; 3,5-Dimethylpyrazole-4-carboxylic acid ethyl ester; UNII-SS3UNU86DP; SS3UNU86DP; 3.5. Dimethylpyrazol 4-carbonsaeureaethyl ester; MFCD00159638; 1H-Pyrazole-4-carboxylic acid, 3,5-dimethyl-, ethyl ester; BRN 0123695; 3.5. Dimethylpyrazol 4-carbonsaeureaethyl ester [German]; Maybridge1_007838; Pyrazole carboxylic ester 2; 5-25-04-00140 (Beilstein Handbook Reference); ETHYL3,5-DIMETHYL-1H-4-PYRAZOLECARBOXYLATE; ARONIS24039; SCHEMBL353564; CHEMBL506972; BDBM14779; CTK4H5169; HMS563M06; KS-00000BFS; DTXSID80189206; HMS3604G06; ZINC109930; KS-000046HR; ANW-74092; SBB088178; STK400197; 3,5-dimethyl-4-ethoxycarbonylpyrazole; AKOS004902412; AB04188; AC-9356; DB04271; MCULE-6003338657; Ethyl3,5-Dimethylpyrazole-4-carboxylate; AK-82636; AM803772; SY006731; DB-026565; FT-0679972; ST45053228; Y8850; K-8058; Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate #; 3,5-DiMethylpyrazole-4-carboxylicacid ethyl ester; A822943; AE-848/30748041; 10X-0839; J-520829; Q27095091; Pyrazole-4-carboxylic acid, 3,6-dimethyl-, ethyl ester; Z1354602508; 1H-Pyrazole-4-carboxylicacid, 3,5-dimethyl-, ethyl ester; Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, AldrichCPR
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| Activity |
IC50 = 82000 nM
|
[12] | |||
| Compound Name |
4-(3-Fluorophenyl)-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propyl)pyridazino[4,5-b]indolizin-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092166; BDBM50314562
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| Activity |
Ki = 83000 nM
|
[5] | |||
| Compound Name |
Chembl4289060
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Investigative | Compound Info | ||
| Synonyms |
BDBM50466918
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| Activity |
IC50 = 87300 nM
|
[6] | |||
| Compound Name |
Chembl4283822
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Investigative | Compound Info | ||
| Synonyms |
BDBM50466926
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| Activity |
IC50 = 88200 nM
|
[6] | |||
| Compound Name |
Chembl4174666
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Investigative | Compound Info | ||
| Synonyms |
BDBM50466947
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| Activity |
IC50 = 88300 nM
|
[4] | |||
| Compound Name |
Chembl4165955
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466944
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| Activity |
IC50 = 89200 nM
|
[4] | |||
| Compound Name |
7-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-2-methyl-quinazolin-4-ylamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186868; BDBM50151562
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| Activity |
IC50 = 92330 nM
|
[8] | |||
| Compound Name |
Chembl4204765
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Investigative | Compound Info | ||
| Synonyms |
BDBM50455395
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| Activity |
IC50 = 92580 nM
|
[13] | |||
| Compound Name |
4-(2-Methoxy-4-pentanoylphenoxy)piperidine-1-carboxylic Acidtert-Butyl Ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL455962; BDBM50273984
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| Activity |
IC50 = 93000 nM
|
[9] | |||
| Compound Name |
4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-benzoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL362264; SCHEMBL4247510; SCHEMBL4247512; BDBM50151550; methyl 4-(5-cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)benzoate
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| Activity |
IC50 = 95500 nM
|
[8] | |||
| Compound Name |
Chembl4162324
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Investigative | Compound Info | ||
| Synonyms |
BDBM50466950
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| Activity |
IC50 = 96800 nM
|
[4] | |||
| Compound Name |
5-[2-(2-Aminoethoxy)ethoxy]-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184701; BDBM50151643
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|
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| Activity |
IC50 = 99000 nM
|
[7] | |||
| Compound Name |
(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyridin-4-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090703; BDBM50314576
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|
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pentan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL456366; BDBM50273331
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|
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| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
1-(4-(3-(4-(3-Fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090017; BDBM50314565
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
(4-(3-(1,2-Dimethyl-7-phenyl-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093071; BDBM50314572
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|
||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
(4-(3-(4-Phenylpyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)(pyrazin-2-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090016; BDBM50314558
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Ethyl 2-[4-[3,5-bis(cyclopropylmethoxy)phenyl]-6-methoxy-2-methylquinazolin-7-yl]oxyacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97213; BDBM50072207
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|
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(isoxazol-5-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091448; BDBM50314579
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|
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
1-(4-(3-(4-(3-Fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093347; BDBM50314566
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462517; BDBM50273923
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|
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[4-[3,5-Bis(cyclopropylmethoxy)phenyl]-2-ethyl-7-(2-hydroxyethoxy)quinazolin-6-yl]oxyethanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319809; BDBM50072193; 2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-7-(2-hydroxy-ethoxy)-quinazolin-6-yloxy]-ethanol
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4281304
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|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(4-(3-(7-(3-Fluorophenyl)-1,2-dimethyl-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090701; BDBM50314574
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL446547; BDBM50273921
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pentan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462448; BDBM50273924
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
7-Benzyloxy-4-(3,5-bis-cyclopropylmethoxy-phenyl)-2-ethyl-6-methoxy-quinazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99470; BDBM50072202
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pentan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL507064; BDBM50273922
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090702; BDBM50314575
Click to Show/Hide
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||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
7-(5-Cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364813; SCHEMBL4250343; BDBM50151572; 7-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-quinazolin-4-ylamine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-N-(2-dimethylamino-ethyl)-N-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183040; SCHEMBL4249391; SCHEMBL4249400; BDBM50151537; 4-(5-cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)-N-[2-(dimethylamino)ethyl]-N-methylbenzamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365494; SCHEMBL4251966; BDBM50151558; N-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-cyclohexane-1,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
5-(3-Chlorophenyl)-N-cyclohexyl-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184416; SCHEMBL4250431; BDBM50151556; [5-(3-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-cyclohexyl-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185531; SCHEMBL4249533; SCHEMBL4249536; BDBM50151525; 2-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-(3-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365206; SCHEMBL4246678; SCHEMBL4246681; BDBM50151529; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-(3-fluoro-phenyl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-(4-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362719; SCHEMBL4250388; SCHEMBL4250390; BDBM50151559; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-(4-fluoro-phenyl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-cyclooctyl-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365621; BDBM50151564; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-cyclooctyl-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
5-(4-Chlorophenyl)-3-methyl-N-pentan-3-yl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365402; SCHEMBL4246348; BDBM50151557; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-(1-ethyl-propyl)-amine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-2-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185173; SCHEMBL4249974; SCHEMBL4249976; BDBM50151578; 4-(5-cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)-2-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
[1-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]cyclopentyl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361053; SCHEMBL4250300; SCHEMBL4250301; BDBM50151549; {1-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-cyclopentyl}-methanol
Click to Show/Hide
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||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
N-(3-Bicyclo[2.2.1]heptanyl)-5-(4-chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183789; SCHEMBL4246635; SCHEMBL4246637; BDBM50151563; Bicyclo[2.2.1]hept-2-yl-[5-(4-chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-amine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185532; SCHEMBL4253515; SCHEMBL4253519; BDBM50151539; 3-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-phenol
Click to Show/Hide
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||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183156; SCHEMBL4253575; SCHEMBL4253577; BDBM50151536; 4-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[8] | |||
| Compound Name |
1-[4-Methoxy-3-(piperidin-4-yloxy)phenyl]pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460189; BDBM50273509
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[9] | |||
| Compound Name |
Chembl4206447
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455390
Click to Show/Hide
|
||||
| Activity |
IC50 = 133560 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors. J Med Chem. 2005 Feb 24;48(4):1237-43. | ||||
| REF 2 | Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. | ||||
| REF 3 | Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17(1):337-43. | ||||
| REF 4 | Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3271-3275. | ||||
| REF 5 | Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2163-7. | ||||
| REF 6 | Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3276-3280. | ||||
| REF 7 | Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4627-31. | ||||
| REF 8 | Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4607-13. | ||||
| REF 9 | Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. J Med Chem. 2008 Dec 25;51(24):7673-88. | ||||
| REF 10 | Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds. J Med Chem. 2012 Apr 12;55(7):3274-84. | ||||
| REF 11 | Design, synthesis, and evaluation of 2-aryl-7-(3',4'-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):922-6. | ||||
| REF 12 | Fragment-Based Drug Discovery of Phosphodiesterase Inhibitors. J Med Chem. 2018 Feb 22;61(4):1415-1424. | ||||
| REF 13 | Structure-based design and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1188-1193. | ||||
| REF 14 | Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2891-6. | ||||
| REF 15 | Identification of imidazo[1,2- b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8(4):700-712. | ||||
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