Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02703 | Target Info | |||
| Target Name | Nitric-oxide synthase inducible (NOS2) | ||||
| Synonyms |
iNOS; Peptidyl-cysteine S-nitrosylase NOS2; Nitric oxide synthase, inducible; NOS2A; NOS type II; Inducible NOS; Inducible NO synthase; Hepatocyte NOS; HEP-NOS
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NOS2 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 169 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Hexahydro-cyclopenta[b]pyrrol-(2Z)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361419; Hexahydro-cyclopenta[b]pyrrol-(2Z)-ylideneamine; BDBM50150921
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Hexahydro-pyrrolizin-(3E)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hexahydro-pyrrolizin-(3E)-ylideneamine; CHEMBL185535; 765304-80-1; 3h-pyrrolizin-3-imine,hexahydro-; BDBM50150910
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397745; 1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea
Click to Show/Hide
|
||||
| Activity |
IC50 = 97000 nM
|
[2] | |||
| Compound Name |
4-Propylpyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Propyl-pyridin-2-ylamine; 4-Propylpyridin-2-ylamine; 2-Amino-4-propylpyridine; 2-Pyridinamine,4-propyl-; 4-propyl-2-pyridinamine; CHEMBL59235; 4-propylpyridine-2-amine; 2-amino-4-propyl pyridine; 2-Amino-4- propylpyridine; 2-Amino-4-n-propylpyridine; 2--Amino-4-n-propylpyridine; SCHEMBL105611; CTK5B3602; DTXSID00427455; ZINC2582067; 2922AJ; BDBM50091812; AKOS013445809; 2-AMINO-4-(N-PROPYL)PYRIDINE; AB03633; QC-4949; VZ29702; AB0095934; DB-053969; FT-0640775; Z-6708; A833379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N'-[4-(1H-Pyrazol-5-yl)phenyl]ethanimidamide;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543381
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-(4-Acetylphenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543143
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
2-Methyl-octahydro-benzo[b][1,4]thiazepin-(4E)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186360; BDBM50155781
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N'-[4-(Dimethylamino)phenyl]ethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544789
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
6-Methyl-[1,4]thiazepan-(5E)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188073; BDBM50155791; AKOS006379603
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[[4-(1-Aminoethylideneamino)phenyl]methyl]morpholine-4-carboxamide;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554248
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-(4-Cyanophenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL545023
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
6,7-Dihydro-5H-cyclopenta[b]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-amino-6,7-dihydro-5h-1-pyrindine; CHEMBL292690; 5H,6H,7H-cyclopenta[b]pyridin-2-amine; 5H-Cyclopenta[b]pyridin-2-amine, 6,7-dihydro-; SCHEMBL3162510; BDBM50091795; ZINC18531795; AKOS004120953; 6,7-Dihydro-5H-[1]pyrindin-2-ylamine; Z1198183883
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N'-[4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)phenyl]ethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542910
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
Hexahydro-indolizin-(3E)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185600; BDBM50150925
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Amino-4-chloropyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-chloropyridin-2-amine; 4-Chloro-pyridin-2-ylamine; 2-Pyridinamine, 4-chloro-; 4-Chloro-2-pyridinamine; 2-Amino-4-chloro pyridine; MFCD04113820; 4-chloro-2-pyridylamine; 2-amino-4-chloro-pyridine; CHEMBL293728; 2-Amino-4-chloropyridine, 97%; Pyridines; zlchem 258; PubChem5695; 4-chlorpyridin-2-amine; 2-Amino4-chloropyridine; 2-amino-4-chloropyridin; 4-chloro pyridin-2-amine; 4-chloro-2-pyridinylamine; 4-chloropyridin-2-ylamine; ACMC-209f2e; 4-chloro-2-amino-pyridine; 2-Amino-4-chloropyrinidine; 4-Chloro-2-pyridinamine #; AF-399/42648911; KSC174S0B; SCHEMBL200134; (4-chloro-pyridin-2-yl)-amine; CTK0H4900; 4-CHLORO-2-AMINOPYRIDINE; DTXSID70342444; ZLC0070; HMS1655J15; ACT01317; BCP27213; EBD35685; ANW-23796; BBL011142; BDBM50091810; CA0058; SBB051892; STK802454; WT2255; ZINC19735878; (R)-2-Amino-7-phosphonoheptanoicacid; AKOS000320218; AC-2716; CCG-303312; CS-W008962; LS20373; MCULE-8549815465; PB32361; PS-5339; QC-9998; AK-23590; BR-23590; SC-02165; SY002647; 19798-80-2 4-Chloro-2-aminopyridine; AB0005623; DB-000134; AM20050920; FT-0602556; ST45175164; A-6379; 798A802; Q-200231; F1926-0004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[4-(1-Aminoethylideneamino)phenyl]acetic acid;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555389
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
Tetrahydro-pyrrolo[1,2-c]thiazol-(3Z)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360669; BDBM50150932
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N'-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]ethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542913
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-[4-(Hydroxymethyl)phenyl]ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542431
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Fluorobenzo[d]oxazol-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Fluoro-1,3-benzoxazol-2(3H)-one; 5-Fluoro-2(3H)-benzoxazolone; 5-fluoro-3H-1,3-benzoxazol-2-one; 5-Fluoro-3H-benzooxazol-2-one; CHEMBL101266; MFCD08059539; 5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one; 5-Fluorobenzoxazol-2(3H)-one; NSC146763; ACMC-20am3n; 5-fluoro-benzoxazol-2-one; 5-Fluoro-2-benzoxazolinone; 5-Fluorobenzoxazolin-2-one; SCHEMBL244162; 5-Fluoro-3H-benzoxazol-2-one; CTK4B9228; KS-00000SFR; 2(3H)-Benzoxazolone,5-fluoro-; DTXSID50301852; 5-fluoro-3-hydrobenzoxazol-2-one; 5-Fluoro-2-hydroxybenzo[d]oxazole; ZINC1728885; BDBM50290804; EBD177944; SBB086882; AKOS011655126; 5-Fluoro-2(3H)-benzoxazolone, 96%; CCG-339791; DS-9112; NSC-146763; 5-fluoranyl-3H-1,3-benzoxazol-2-one; 5-Fluoro-2,3-dihydrobenzoxazole-2-one; AK157798; BP-13411; SY101449; CS-0038220; Z9761; A-8554; A806789; J-006548; Z1889710358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-Acetimidoylamino-Benzoic Acid HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540555
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Methyl-4,5-dihydro-1,3-thiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185505; 5-methyl-4,5-dihydro-thiazol-2-ylamine; 2-amino-5-methylthiazoline; SCHEMBL6637787; SCHEMBL9870593; 2-amino-5-methyl-2-thiazoline; 5-methyl-1,3-thiazolidin-2-imine; BDBM50150913; AKOS006220699; MCULE-5641549444; 5-Methyl-thiazolidin-(2E)-ylideneamine; Thiazole, 2-amino-4,5-dihydro-5-methyl-; 5-Methyl-4,5-dihydro-1,3-thiazol-2-amine #
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Spiro[1H-quinazoline-2,4'-piperidine]-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171556; SCHEMBL7804498; Spiro[piperidine-4,2'(1'H)-quinazolin]-4'-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N'-(4-Methylsulfanylphenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544557
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
Hexahydro-thiazolo[3,4-a]pyridin-(3Z)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185867; BDBM50150934
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N'-(4-Nitrophenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540299
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-[4-(1-Hydroxyethyl)phenyl]ethanimidamide;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542677
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Aminoisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoquinolin-3-amine; 3-Isoquinolinamine; Isoquinolin-3-ylamine; Isoquinoline, 3-amino-; Isoquinoline-3-amine; CHEMBL61743; 3-isoquinolylamine; isoquinolin-3-imine; NSC218383; zlchem 309; PubChem6217; isoquinoline-3-ylamine; uPa_46; 3-Aminoisoquinoline, 97%; SCHEMBL177520; 3-aminoisoquinoline, AldrichCPR; CTK1A3054; CTK4C1857; ZLC0134; WT720; ZINC157801; ACT01923; ANW-50449; BBL101046; BDBM50091818; MFCD00102190; SBB051996; STL554840; 25475-67-6 isoquinolin-3-amine; AKOS005256578; AB03416; CS-W009009; LS20125; NSC-218383; PS-4190; QC-9358; SDCCGMLS-0065877.P001; VQ10150; KS-00002A44; AC-26693; AK-27774; BR-27774; SC-02915; AB0005934; DB-011136; A5134; AM20051003; C2373; FT-0627505; S-2565; 71442-EP2295432A1; 71442-EP2308833A2; 475I676; W-202073
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 2-[4-(1-aminoethylideneamino)phenyl]acetate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL545256
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
4-Methyl-1,3-benzoxazol-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Methylbenzoxazol-2(3H)-one; 4-Methyl-3H-benzooxazol-2-one; CHEMBL320850; 4-methyl-3H-benzoxazol-2-one; MFCD16742805; 4-methyl-2,3-dihydro-1,3-benzoxazol-2-one; methyl-benzoxazolinone; SCHEMBL1285749; 4-Methylbenzoxazole-2(3H)-one; 4-methyl-3H-benz-oxazol-2-one; 2(3H)-Benzoxazolone, 4-methyl-; 2-Hydroxy-4-methylbenzo[d]oxazole; KS-00003T1Q; 4-methylbenzo[d]oxazol-2(3H)-one; BDBM50290809; ZINC26728949; AKOS011655123; SB22918; SY130158; TS-01951; DB-123531; 4-METHYL-3H-1,3-BENZOXAZOL-2-ONE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
6-Methyl-1,3-benzoxazol-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methylbenzo[d]oxazol-2(3H)-one; 6-methyl-3H-1,3-benzoxazol-2-one; 6-Methylbenzoxazol-2(3H)-one; 6-Methyl-3H-benzooxazol-2-one; 2(3H)-Benzoxazolone, 6-methyl-; CHEMBL95524; MFCD02090051; NSC280712; 6-methylbenzoxazolin-2-one; SCHEMBL244119; CTK1A3737; DTXSID80314112; ZINC163636; 2-Hydroxy-6-methylbenzo[d]oxazole; ALBB-013599; 7799AD; BDBM50290819; AKOS005174094; NSC-280712; BP-20116; SC-32249; SY081557; DS-009133; R5460; 6-Methyl-1,3-benzoxazol-2(3H)-one, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-Phenyl-4,5-dihydro-1,3-thiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183268; SCHEMBL6257456; 4-phenyl-1,3-thiazolidin-2-imine; BDBM50150917; MCULE-6223280688; 4-Phenyl-thiazolidin-(2E)-ylideneamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N'-[4-(Pyrazol-1-ylmethyl)phenyl]ethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553132
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-(4-Methoxyphenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544093; SR-01000439374; SR-01000439374-1
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[3-(Aminomethyl)phenyl]-N'-methylethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544559
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Chloro-2-mercaptobenzoxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-chlorobenzo[d]oxazole-2-thiol; 5-chloro-1,3-benzoxazole-2-thiol; 5-Chlorobenzooxazole-2-thiol; 5-Chlorobenzo[d]oxazole-2(3H)-thione; 5-chloro-benzooxazole-2-thiol; 2(3H)-Benzoxazolethione, 5-chloro-; 5-chloro-3H-1,3-benzoxazole-2-thione; 2-Mercapto-5-chlorobenzoxazole; 5-Chloro-2-thioxobenzoxazoline; 2-Benzoxazolethiol, 5-chloro-; BENZOXAZOLE, 5-CHLORO-2-MERCAPTO-; 5-Chloranyl-3~{h}-1,3-Benzoxazole-2-Thione; CHEMBL99703; 5-CHLOROBENZOXAZOLE-2-THIOL; MFCD00175241; 5-chloro-3-hydrobenzoxazole-2-thione; 2-Benzoxazolinethione, 5-chloro-; NSC 26187; NSC26187; PubChem8704; ACMC-20am4o; Maybridge1_007032; SCHEMBL777690; 5-chloro-2-mercapto-benzoxazol; CTK6H2118; HMS561H14; DTXSID10177419; ZINC349058; 5-Chloro-2-mercaptobenzo[d]oxazole; 5-Chloro-3H-benzooxazole-2-thione; ACT09314; ALBB-004124; BCP15804; CS-M1396; EBD24321; BBL025677; BDBM50290805; CCG-54507; NSC-26187; SBB003707; STK502094; 5-Chloro-2-mercaptobenzoxazole, 97%; 5-Chlorobenzo[d]oxazole-2(3H)thione; AKOS000116656; AKOS015912994; AB04398; AS07121; DS-2753; MCULE-7527631705; KS-00000F42; 2-Benzoxazolinethione, 5-chloro- (8CI); 5-Chloro-1,3-benzoxazole-2(3H)-thione; AK111072; AM803553; BP-10021; ST059829; AB0005810; DB-021258; DB-029117; BB 0240843; FT-0638260; Z4453; 2(3H)-Benzoxazolethione, 5-chloro- (9CI); EN300-04022; 4B-098; M-7804; 5-chloro-2,3-dihydro-1,3-benzoxazole-2-thione; 876C193; SR-01000643599-1; W-201953; Q27456066; Z56824483
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-Phenyl-Acetamidine Hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553453
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Phenyl-3,4-dihydro-2h-pyrrol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364781; BRN 0472717; 3,4-Dihydro-3-phenyl-2H-pyrrol-5-amine; 2H-Pyrrol-5-amine, 3,4-dihydro-3-phenyl-; 4-Phenylpyrrolidin-2-imine; 5-22-10-00040 (Beilstein Handbook Reference); SCHEMBL11497728; DTXSID80945001; BDBM50150918; 4-Phenyl-pyrrolidin-(2Z)-ylideneamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Oxazolo[4,5-b]pyridin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3H-Oxazolo[4,5-b]pyridin-2-one; 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one; Oxazolo(4,5-b)pyridin-2(3H)-one; [1,3]oxazolo[4,5-b]pyridin-2-ol; [1,3]oxazolo[4,5-b]pyridin-2(3H)-one; CHEMBL329270; MFCD00204215; 2H,3H-[1,3]oxazolo[4,5-b]pyridin-2-one; 3H-[1,3]oxazolo[4,5-b]pyridin-2-one; PubChem11061; SCHEMBL340652; 2-oxooxazolo[4,5-b]pyridine; oxazolo[4,5-b]pyridin-2-one; SCHEMBL22221895; CTK2F7580; DTXSID50209667; ACT01337; BCP10943; 1,3-oxazolo[4,5-b]pyridin-2-ol; ANW-50287; BDBM50290808; MFCD09065038; RW4042; SBB085918; ZINC14989119; Oxazolo[4,5-b]pyridine-2(3H)-one; AKOS006229689; AKOS015855703; AS-5312; MCULE-3642289517; QC-3645; KS-00000E76; 2,3-Dihydropyrido[2,3-d][1,3]oxaz; AC-24171; AK-28047; BR-28047; CS-10384; SC-17102; SY007988; AB0013108; DB-006454; AM20061876; CS-0012220; FT-0601106; EN300-93029; 32D726; A-2477; Z-8130; [1,3]oxazolo[4,5-b]pyridin-2-ol, AldrichCPR; 832O726; W-200556; Q27117908; 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N'-(4-Fluorophenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554192
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-(4-Bromophenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544790; SCHEMBL2860585
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
Tert-butyl 4-(1-aminoethylideneamino)benzoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542909
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
2,3,6,7-Tetrahydro-1H-1,4-diazepin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361049; SCHEMBL2760930; [1,4]Diazepan-(5E)-ylideneamine; BDBM50155793; AKOS006379981
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N'-[4-(2-Morpholin-4-yl-2-oxoethyl)phenyl]ethanimidamide;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539802
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
4-Acetimidoylamino-Benzamide HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540558
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-[4-[(Pyridin-2-ylamino)methyl]phenyl]ethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557337
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
Piperidine-3-Carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783074; BDBM50346523; AKOS017553409
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[8] | |||
| Compound Name |
Chembl2203710
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142586; BDBM50401274
Click to Show/Hide
|
||||
| Activity |
IC50 = 51700 nM
|
[9] | |||
| Compound Name |
2,2-Dimethyl-1H-quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL173006; SCHEMBL7806667; BDBM50124523; 4-Quinazolinamine, 1,2-dihydro-2,2-dimethyl-; 2,2-Dimethyl-1,2-dihydro-quinazolin-4-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[7] | |||
| Compound Name |
N'-[3-(1-Azabicyclo[2.2.2]octan-3-yl)-1H-indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142317
Click to Show/Hide
|
||||
| Activity |
IC50 = 52100 nM
|
[10] | |||
| Compound Name |
Ethyl N'-(4-nitrophenyl)carbamimidothioate;hydroiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543092
Click to Show/Hide
|
||||
| Activity |
Ki = 54000 nM
|
[11] | |||
| Compound Name |
N'-[3-[(1R,3S)-3-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036272
Click to Show/Hide
|
||||
| Activity |
IC50 = 54100 nM
|
[12] | |||
| Compound Name |
N'-[3-[(1S,3S)-3-(Ethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036276
Click to Show/Hide
|
||||
| Activity |
IC50 = 54200 nM
|
[12] | |||
| Compound Name |
Ethyl N'-[4-(trifluoromethoxy)phenyl]carbamimidothioate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554651; SCHEMBL7785801
Click to Show/Hide
|
||||
| Activity |
Ki = 55000 nM
|
[11] | |||
| Compound Name |
Chembl1957354
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122273; CHEMBL1963156; BDBM106700; US8586620, 47; N'-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[13] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216999
Click to Show/Hide
|
||||
| Activity |
IC50 = 55200 nM
|
[14] | |||
| Compound Name |
N'-[3-[1-[2-(3-Chlorophenyl)ethyl]-4-hydroxypiperidin-4-yl]phenyl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220997
Click to Show/Hide
|
||||
| Activity |
IC50 = 57500 nM
|
[15] | |||
| Compound Name |
Chembl1957350
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122065; CHEMBL1963528; BDBM106699; US8586620, 46; N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[13] | |||
| Compound Name |
Chembl1957353
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122005; CHEMBL1963529; BDBM106697; US8586620, 43; N'-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[13] | |||
| Compound Name |
Piperidine-4-Carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PIPERIDINE-4-CARBOXAMIDINE; CHEMBL1783089; 4-Piperidinecarboximidamide; SCHEMBL3649561; DTXSID30621005; ZINC2547899; 4464AJ; BDBM50346524; AKOS006328601; NE63598; SB40192; DB-080183; FT-0767606
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[8] | |||
| Compound Name |
Chembl2206931
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216789; BDBM50401275
Click to Show/Hide
|
||||
| Activity |
IC50 = 58200 nM
|
[9] | |||
| Compound Name |
N'-[3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216993
Click to Show/Hide
|
||||
| Activity |
IC50 = 58200 nM
|
[16] | |||
| Compound Name |
N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216551
Click to Show/Hide
|
||||
| Activity |
IC50 = 58500 nM
|
[16] | |||
| Compound Name |
N'-[4-[2-(2-Hydroxyethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4572090; CHEMBL3675244; BDBM111490; US8618286, 16
Click to Show/Hide
|
||||
| Activity |
IC50 = 58700 nM
|
[17] | |||
| Compound Name |
N'-[1-[2-(Dimethylamino)ethyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216301
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[18] | |||
| Compound Name |
Benzyl 4-[3-[[amino(thiophen-2-yl)methylidene]amino]phenyl]-4-hydroxypiperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220996
Click to Show/Hide
|
||||
| Activity |
IC50 = 60100 nM
|
[15] | |||
| Compound Name |
N'-[4-[2-(2-Hydroxyethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499723; CHEMBL3675253; BDBM111500; US8618286, 26
Click to Show/Hide
|
||||
| Activity |
IC50 = 60100 nM
|
[17] | |||
| Compound Name |
(R)-3-(3-Acetimidoylamino-propylsulfanyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158297; BDBM50086465; S-[3-(1-Iminoethylamino)propyl]-L-cysteine
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[19] | |||
| Compound Name |
N'-[4-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499444; CHEMBL3675240; BDBM111486; US8618286, 12; N-(4-(2-(dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 62900 nM
|
[17] | |||
| Compound Name |
Ethyl 4-[[amino(ethylsulfanyl)methylidene]amino]benzoate;hydroiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL545670
Click to Show/Hide
|
||||
| Activity |
Ki = 63000 nM
|
[11] | |||
| Compound Name |
N-{2-[1-(Tetrahydro-pyran-4-yl)-piperidin-4-ylamino]-benzothiazol-6-yl}-thiophene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389312; BDBM50206069
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[2] | |||
| Compound Name |
N'-[1-[4-(Dimethylamino)butyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216739
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[18] | |||
| Compound Name |
N'-[4-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499591; CHEMBL3675254; BDBM111501; US8618286, 27; N-(4-(2-(dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 66500 nM
|
[17] | |||
| Compound Name |
N'-[1-[2-(1-Methylpyrrolidin-2-yl)ethyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216522
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[18] | |||
| Compound Name |
N'-[3-[3-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036273
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[12] | |||
| Compound Name |
N'-[1-(3-Morpholin-4-ylpropyl)indol-6-yl]thiophene-3-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122092; CHEMBL3216500
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[18] | |||
| Compound Name |
N'-[4-[2-(Methylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499175; CHEMBL3675236; BDBM111482; US8618286, 8; N-(4-(2-(Methylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 70600 nM
|
[17] | |||
| Compound Name |
N'-[1-[2-[(2S)-1-Methylpyrrolidin-2-yl]ethyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216280
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[18] | |||
| Compound Name |
N'-[1-[2-[(2R)-1-Methylpyrrolidin-2-yl]ethyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142303
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[10] | |||
| Compound Name |
N'-[1-(1-Methylazepan-4-yl)indol-5-yl]furan-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142301
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[20] | |||
| Compound Name |
N'-[1-[2-(2-Hydroxyethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217010
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[21] | |||
| Compound Name |
2-Benzyl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553678
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[22] | |||
| Compound Name |
(2R)-2-Amino-3-[(2R)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951128
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[23] | |||
| Compound Name |
N-(2-{1-[2-(4-Bromo-phenyl)-ethyl]-piperidin-4-ylamino}-benzothiazol-6-yl)-thiophene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233654; BDBM50206068
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
N'-(4-Piperidin-4-yl-2,3-dihydro-1,4-benzothiazin-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499977; CHEMBL3675256; BDBM111503; US8618286, 29; N-(4-(piperidin-4-yl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 76800 nM
|
[17] | |||
| Compound Name |
8-Chloro-6,7-difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87219; BDBM50117553; (3aR)-6,7-Difluoro-8-chloro-2,3,3aalpha,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[24] | |||
| Compound Name |
N-(2-Amino-benzothiazol-5-yl)-thiophene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233228; SCHEMBL1677732; BDBM50206067; N'-(2-amino-1,3-benzothiazol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[2] | |||
| Compound Name |
N'-[1-(3-Morpholin-4-ylpropyl)indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216283
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[18] | |||
| Compound Name |
3-(3-Acetimidoylamino-phenyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL49010; BDBM50289678
Click to Show/Hide
|
||||
| Activity |
Ki = 82000 nM
|
[25] | |||
| Compound Name |
N'-[4-[2-(Ethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499857; CHEMBL3675251; BDBM111498; US8618286, 24; N-(4-(2-(Ethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 82300 nM
|
[17] | |||
| Compound Name |
N'-[1-[4-(Methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956107; CHEMBL1956108; SCHEMBL19379236; SCHEMBL19379239; BDBM50365330; BDBM50365339
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[26] | |||
| Compound Name |
Chembl1957352
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122058; CHEMBL1963179; BDBM106701; US8586620, 51; N'-[[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]methyl]thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[13] | |||
| Compound Name |
N'-[[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]methyl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122314; CHEMBL3216320
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[16] | |||
| Compound Name |
N,4,6-Trimethylpyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112139; (4,6-Dimethyl-pyridin-2-yl)-methyl-amine; 4,6-dimethyl-2-methylaminopyridine; SCHEMBL943294; BDBM50148165; AKOS006351330
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[27] | |||
| Compound Name |
8-Trifluoromethyl-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313001; BDBM50117557; (3aR)-8-(Trifluoromethyl)-2,3,3aalpha,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[24] | |||
| Compound Name |
N'-[1-[2-(Propan-2-ylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215675
Click to Show/Hide
|
||||
| Activity |
IC50 = 89400 nM
|
[21] | |||
| Compound Name |
N-{2-[1-(4-Fluoro-benzyl)-piperidin-4-ylamino]-benzothiazol-5-yl}-thiophene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233648; BDBM50206071
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[2] | |||
| Compound Name |
Chembl2203711
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217218; BDBM50401273
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[9] | |||
| Compound Name |
N'-[1-[3-(Dimethylamino)propyl]indol-5-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217185
Click to Show/Hide
|
||||
| Activity |
IC50 = 95100 nM
|
[20] | |||
| Compound Name |
2-Amino-3-[3-(N''-methyl-guanidino)-phenyl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL48861; BDBM50289679
Click to Show/Hide
|
||||
| Activity |
Ki = 96000 nM
|
[25] | |||
| Compound Name |
N-Benzyl-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911885; SCHEMBL3567859; BDBM50356507
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
n-Methyl-3,4,5,6-tetrahydropyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268294; NSC157920; 2-PYRIDINAMINE, 3,4,5,6-TETRAHYDRO-N-METHYL-; N-methyliminopiperidine; N-Methyl-2-piperidinimine; N-methyl-2,3,4,5-tetrahydropyridin-6-amine; SCHEMBL7623417; SCHEMBL10070969; CTK4G8884; DTXSID60303342; ZINC5158898; BDBM50062144; Methyl-piperidin-(2Z)-ylidene-amine; AKOS006349763; MCULE-3924232585; NE60857; NSC-157920; 2,3,4,5-tetrahydro-6-(methylamino)pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
4-(4-{6-[(Thiophene-2-carboximidoyl)-amino]-benzothiazol-2-ylamino}-piperidin-1-ylmethyl)-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234499; BDBM50206063
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-[1-(1-Methylpyrrolidin-3-yl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216558
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
1-Methyl-2-piperidinimine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-Methylpiperidin-2-imine; CHEMBL266980; 1-methyl-piperidin-2-ylideneamine; 2-imino-1-methylpiperidine; 2-imino-1 -methylpiperidine; SCHEMBL7622419; DTXSID00498746; BDBM50062141; 1-Methyl-piperidin-(2Z)-ylideneamine; AKOS010784835
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
N'-[4-[2-(Dimethylamino)ethyl]-3-oxo-1,4-benzoxazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL500027; CHEMBL3675233; BDBM111479; US8618286, 5
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N'-[1-[2-(Ethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217217
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911997; SCHEMBL3567034; BDBM50356503
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N'-[4-[2-(Ethylamino)ethyl]-2,3-dihydro-1,4-benzoxazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499625; CHEMBL3675235; BDBM111481; US8618286, 7; N-(4-(2-(Ethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
CID 11523510
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911891; SCHEMBL3561903; BDBM50356513; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N-(1H-indol-5-ylmethyl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N'-[1-[2-(1-Methylpyrrolidin-2-yl)ethyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N'-[1-[2-[2-Hydroxyethyl(methyl)amino]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216120
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4-(4-{6-[(Thiophene-2-carboximidoyl)-amino]-benzothiazol-2-ylamino}-piperidin-1-ylmethyl)-benzoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397710; BDBM50206075
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-[1-(4-Imidazol-1-ylbutyl)indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216080
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[2-[1,3-Benzodioxol-5-ylmethyl(methyl)amino]ethyl]-2-imidazol-1-yl-6-methylpyrimidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911988; BDBM50356502
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N'-[4-[2-(1-Methylpyrrolidin-2-yl)ethyl]-3-oxo-1,4-benzoxazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4572081; CHEMBL3675229; BDBM111475; US8618286, 1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N'-[1-(2-Piperidin-1-ylethyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216552
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
3,4-Dimethoxy-2-(methylsulfanylmethyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800525; BDBM50418848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
Pyridinone, 27
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521786; BDBM29256
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
N-{2-[1-(3-Methoxy-benzyl)-piperidin-4-ylamino]-benzothiazol-6-yl}-thiophene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233655; BDBM50206065
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-(1-Piperidin-4-yl-3,4-dihydro-2H-quinolin-6-yl)thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217198
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
Quinoline, 32
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490726; BDBM29262; N-(3-chlorophenyl)-N-[(8-fluoroquinolin-4-yl)methyl]-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
N'-[1-[2-(Dimethylamino)ethyl]-8-fluoro-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216545
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1185460; SCHEMBL232295; BDBM50418843
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
CID 11631971
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911889; SCHEMBL3566838; BDBM50356511
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N'-[1-[2-(Methylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2675930; CHEMBL3216121
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N'-(1-Piperidin-4-yl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215662
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
N'-[1-(Oxan-4-yl)-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1955934; BDBM50365332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
N'-[2-Oxo-1-(2-piperidin-1-ylethyl)-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(S)-3-(3-Acetimidoylamino-propoxy)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157074; BDBM50086471; O-[3-(1-Iminoethylamino)propyl]-L-serine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N'-[1-(1-Methylpiperidin-4-yl)-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217197
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N'-[1-[2-[Ethyl(methyl)amino]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216119
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N'-[1-[3-(2-Hydroxyethylamino)propyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216787
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N'-(1-Cyclohexyl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1955933; BDBM50365331
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
N-(3-Chlorophenyl)-N-((8-fluoro-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylthiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 31; CHEMBL490122; SCHEMBL5094472; BDBM29260
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
N'-[1-[2-(1-Methylpyrrolidin-2-yl)ethyl]-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216994
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
4-Propyl-2-piperidinimine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6657; BDBM50062130; 4-Propyl-piperidin-(2Z)-ylideneamine; DA-09530; FT-0751966; 4-propyl-2,3,4,5-tetrahydropyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
4-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157846; SCHEMBL5515300; BDBM50086460; 2-amino-4-[2-(1-aminoethylideneamino)ethylsulfonyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-N'-methyl-N'-(6-methyl-2-pyrrol-1-ylpyrimidin-4-yl)propane-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911884; BDBM50356506
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N'-[1-(3-Morpholin-4-ylpropyl)indol-6-yl]furan-3-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122198; CHEMBL3215625
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N'-[2-Oxo-1-(3-pyrrolidin-1-ylpropyl)-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
3-[3-(1-Iminoethylamino)propylsulfonyl]-L-alanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157190; BDBM50086463; (R)-3-(3-Acetimidoylamino-propane-1-sulfonyl)-2-amino-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
4,5-Dimethoxy-2-(methylsulfanylmethyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800524; BDBM50418858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-Amino-3-(3-guanidino-phenyl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL49934; 3-guanidino-DL-phenylalanine; SCHEMBL7260682; 2-amino-3-[3-(diaminomethylideneamino)phenyl]propanoic Acid; BDBM50289682
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[25] | |||
| Compound Name |
N'-[3-[1-[2-(2,3-Dichlorophenyl)ethyl]-4-hydroxypiperidin-4-yl]phenyl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221001
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[15] | |||
| Compound Name |
Quinoline, 30
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492146; BDBM29259; N-(3-chlorophenyl)-N-[(8-fluoro-2-methoxyquinolin-4-yl)methyl]-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
4-(2-Acetimidoylamino-ethanesulfinyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155318; SCHEMBL5512623; BDBM50086469; 2-amino-4-[2-(1-aminoethylideneamino)ethylsulfinyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N'-[1-[3-(Methylamino)propyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N'-[1-[2-(Methylamino)ethyl]-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216995
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
CID 11609610
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911890; SCHEMBL3562106; BDBM50356512; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methyl-N-(pyridin-4-ylmethyl)propane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Saquayamycins A1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071401; BDBM50390001
Click to Show/Hide
|
||||
| Activity |
IC50 = 101200 nM
|
[34] | |||
| Compound Name |
6-(4-Chloro-phenyl)-4-piperidin-1-yl-5,6,7,8-tetrahydro-pteridin-2-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101879; BDBM50115162; 6-(4-chlorophenyl)-4-piperidin-1-yl-5,6,7,8-tetrahydropteridin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 106200 nM
|
[35] | |||
| Compound Name |
N'-[3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216321
Click to Show/Hide
|
||||
| Activity |
IC50 = 107900 nM
|
[16] | |||
| Compound Name |
(R)-2-(S)-Amino-3-methyl-5-(2-methyl-isothioureido)-pentanoic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL196721; BDBM50167727
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[36] | |||
| Compound Name |
N'-[4-[3-(Dimethylamino)propyl]-2,3-dihydro-1,4-benzothiazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499260; CHEMBL3675250; BDBM111496; US8618286, 22; N-(4-(3-(Dimethylamino)propyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 115000 nM
|
[17] | |||
| Compound Name |
N'-[4-(2-Pyrrolidin-1-ylethyl)-2,3-dihydro-1,4-benzothiazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499565; CHEMBL3675239; BDBM111485; US8618286, 11
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[17] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]thiophene-3-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217210
Click to Show/Hide
|
||||
| Activity |
IC50 = 118000 nM
|
[14] | |||
| Compound Name |
1-Benzyl-3-(2-isobutyrylamino-4-oxo-6,7-diphenyl-4,6,7,8-tetrahydro-3H-pteridine-5-carbonyl)-pyridinium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321741; PHS-72; BDBM50115130
Click to Show/Hide
|
||||
| Activity |
IC50 = 122700 nM
|
[35] | |||
| Compound Name |
N-[3-(2-Amino-5-methoxyphenyl)-3-hydroxypropyl]-N'-methylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800212; J3.549.668H
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[37] | |||
| Compound Name |
N'-[4-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]furan-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499671; CHEMBL3675247; BDBM111493; US8618286, 19; N-(4-(2-(dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)furan-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 136000 nM
|
[17] | |||
| Compound Name |
N-[2-(2-Pyridin-2-yl-ethylamino)-benzothiazol-5-yl]-thiophene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395580; BDBM50206072
Click to Show/Hide
|
||||
| Activity |
IC50 = 139000 nM
|
[2] | |||
| Compound Name |
N-[2-(2-Morpholin-4-yl-ethylamino)-benzothiazol-5-yl]-thiophene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233024; BDBM50206081
Click to Show/Hide
|
||||
| Activity |
IC50 = 141000 nM
|
[2] | |||
| Compound Name |
N'-[3-[4-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036268; CHEMBL2036269
Click to Show/Hide
|
||||
| Activity |
IC50 = 142000 nM
|
[12] | |||
| Compound Name |
N'-[3-[4-(Dimethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2034995; CHEMBL2036267
Click to Show/Hide
|
||||
| Activity |
IC50 = 149000 nM
|
[12] | |||
| Compound Name |
N'-[3-[4-(Ethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036270; CHEMBL2036271
Click to Show/Hide
|
||||
| Activity |
IC50 = 155000 nM
|
[12] | |||
| Compound Name |
N'-[4-(2-Piperidin-1-ylethyl)-2,3-dihydro-1,4-benzothiazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499633; CHEMBL3675242; BDBM111488; US8618286, 14; N-(4-(2-(Piperidin-1-yl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 172000 nM
|
[17] | |||
| Compound Name |
N'-[4-[3-(Methylamino)propyl]-2,3-dihydro-1,4-benzothiazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499836; CHEMBL3639741; BDBM111497; US8618286, 23; N-(4-(3-(methylamino)propyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 172000 nM
|
[17] | |||
| Compound Name |
(2R)-2-Amino-3-[(2S)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953808
Click to Show/Hide
|
||||
| Activity |
IC50 = 197000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 41 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-NAME
Click to Show/Hide
|
Phase 2 | Compound Info | ||
| Synonyms |
N-Nitroarginine methyl ester; NG-NITROARGININE METHYL ESTER; N(G)-Nitroarginine methyl ester; N-Nitro-L-arginine methylester; Ngamma-Nitro-L-arginine methyl ester; N(G)-Nitro-L-arginine methyl ester; N(sup G)-Nitro-L-arginine methyl ester; N-omega-Nitro-O-arginine methyl ester; Methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate; Methyl N5-(N'-nitrocarbamimidoyl)-L-ornithinate; N(5)-(Imino(nitroamino)methyl)-L-ornithine methyl ester; N-.omega.-Nitro-O-arginine methyl ester; L-Ornithine, N(5)-(imino(nitroamino)methyl)-, methyl ester; Methyl (2S)-2-amino-5-[(amino-nitramido-methylidene)amino]pentanoate
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000000 nM
|
[38] | |||
| Compound Name |
L-2-Amino-4-(Guanidinooxy)Butyric Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
L-canavanine; canavanine; Canavanin; 543-38-4; 2-Amino-4-(guanidinooxy)butyric acid; L-2-AMINO-4-(GUANIDINOOXY)BUTYRIC ACID; UNII-3HZV514J4B; O-((Aminoiminomethyl)amino)-L-homoserine; O-carbamimidamido-L-homoserine; 3HZV514J4B; CHEMBL443732; CHEBI:609827; (L)-CANAVANINE; O-((Aminoiminomethyl)amino)homoserine; GGB; HSDB 3471; AI3-52153; L-Homoserine, O-((aminoiminomethyl)amino)-; Butyric acid, 2-amino-4-(guanidinooxy)-, L-; C5H12N4O3; L(+)-Canavanine; Tocris-0673; Spectrum_001137; Spectrum3_001206; Spectrum2_000800
Click to Show/Hide
|
||||
| Activity |
Ki = 220000 nM
|
[39] | |||
| Compound Name |
6-(4-Chloro-phenyl)-N*4*-cyclohexylmethyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98547; BDBM50115131; 6-(4-chlorophenyl)-4-N-(cyclohexylmethyl)-5,6,7,8-tetrahydropteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 214200 nM
|
[35] | |||
| Compound Name |
6-Phenyl-N*4*,N*4*-dipropyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185766; BDBM50170718; 6-phenyl-4-N,4-N-dipropyl-5,6,7,8-tetrahydropteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 229800 nM
|
[35] | |||
| Compound Name |
2-[2-[7-[[Amino(thiophen-2-yl)methylidene]amino]-2,3-dihydro-1,4-benzothiazin-4-yl]ethyl-methylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499209; CHEMBL3675245; BDBM111491; US8618286, 17
Click to Show/Hide
|
||||
| Activity |
IC50 = 241000 nM
|
[17] | |||
| Compound Name |
N'-[4-[2-(Methylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]furan-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499888; CHEMBL3675248; BDBM111494; US8618286, 20; N-(4-(2-(methylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)furan-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 268000 nM
|
[17] | |||
| Compound Name |
6-(4-Methoxyphenyl)-4-N,4-N-dipropyl-5,6,7,8-tetrahydropteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100716; BDBM50115168; 6-(4-Methoxy-phenyl)-N*4*,N*4*-dipropyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 280500 nM
|
[35] | |||
| Compound Name |
[(1R)-1-Amino-4-(diaminomethylideneamino)butyl]boronic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448330; BDBM50071730
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[40] | |||
| Compound Name |
6-(4-Chloro-phenyl)-N*4*,N*4*-diethyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319722; BDBM50115159; 6-(4-chlorophenyl)-4-N,4-N-diethyl-5,6,7,8-tetrahydropteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 307400 nM
|
[35] | |||
| Compound Name |
3-Quinolinecarbonitrile, 4-[(2-amino-6-benzothiazolyl)amino]-6-methyl-7-[2-(1-piperidinyl)ethoxy]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486370; 3-Quinolinecarbonitrile,4-[(2-amino-6-benzothiazolyl)amino]-6-methyl-7-[2-(1-piperidinyl)ethoxy]-; BDBM50275756; ZINC45484716; 4-(2-aminobenzo[d]thiazol-6-ylamino)-6-methyl-7-(2-(piperidin-1-yl)ethoxy)quinoline-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 313000 nM
|
[41] | |||
| Compound Name |
(2S)-1-[2-[7-[[Amino(thiophen-2-yl)methylidene]amino]-2,3-dihydro-1,4-benzothiazin-4-yl]ethyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4572079; CHEMBL3675246; BDBM111492; US8618286, 18
Click to Show/Hide
|
||||
| Activity |
IC50 = 341000 nM
|
[17] | |||
| Compound Name |
N'-[4-[2-(Methylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499616; CHEMBL3675255; BDBM111502; US8618286, 28; N-(4-(2-(methylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 348000 nM
|
[17] | |||
| Compound Name |
1-[3-(2-Aminophenyl)-3-hydroxypropyl]-3-methylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798114
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[37] | |||
| Compound Name |
Tert-butyl (2S,3S)-2-amino-3-[2-[[amino(methylsulfanyl)methylidene]amino]ethyl]hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197055; BDBM50167730; (S)-2-(S)-Amino-3-[2-(2-methyl-isothioureido)-ethyl]-hexanoic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 370000 nM
|
[36] | |||
| Compound Name |
4-(1-Diazo-2,2,2-trifluoro-ethyl)-benzoic acid 2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364546; BDBM50170717
Click to Show/Hide
|
||||
| Activity |
IC50 = 374200 nM
|
[35] | |||
| Compound Name |
N',N'-Dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100659; SCHEMBL5518262; BDBM50081585; 4-N,4-N-dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine; N*4*,N*4*-Dibenzyl-6-(4-methoxy-phenyl)-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[35] | |||
| Compound Name |
N',N'-Dibenzyl-6-phenylpteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101399; SCHEMBL5514521; BDBM50081589; 4-N,4-N-dibenzyl-6-phenylpteridine-2,4-diamine; N*4*,N*4*-Dibenzyl-6-phenyl-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 451800 nM
|
[35] | |||
| Compound Name |
N'-(5-Fluoro-1-piperidin-4-yl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956106; BDBM50365338
Click to Show/Hide
|
||||
| Activity |
IC50 = 481000 nM
|
[26] | |||
| Compound Name |
2-Amino-6-(ethoxymethyl)pteridin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188475; 4(1H)-Pteridinone, 2-amino-6-(ethoxymethyl)-; ACMC-20m77o; SCHEMBL10849935; CTK0G6338; DTXSID20545468; BDBM50170720; 2-Amino-6-ethoxymethyl-3H-pteridin-4-one; 2-AMINO-6-(ETHOXYMETHYL)-1H-PTERIDIN-4-ONE
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[35] | |||
| Compound Name |
2-Amino-5-benzoyl-5,6,7,8-tetrahydro-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101495; BDBM50115136
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[35] | |||
| Compound Name |
2-Amino-4-hydroxy-6-(4-fluorophenyl)pteridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98102; SCHEMBL3760493; BDBM50115154; 2-amino-6-(4-fluorophenyl)-1H-pteridin-4-one; 2-Amino-6-(4-fluoro-phenyl)-3H-pteridin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[35] | |||
| Compound Name |
2-Amino-propionic acid 2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359988; BDBM50170719
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[35] | |||
| Compound Name |
2-Amino-6-naphthalen-1-yl-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188157; BDBM50170721
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[35] | |||
| Compound Name |
[(1R)-1-Acetamido-4-(diaminomethylideneamino)butyl]boronic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2448331; BDBM50071731
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[40] | |||
| Compound Name |
N'-[5-Fluoro-1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956109; CHEMBL1956110; BDBM50365340; BDBM50365341
Click to Show/Hide
|
||||
| Activity |
IC50 = 522000 nM
|
[26] | |||
| Compound Name |
6-[[(3S,4S)-1-Benzyl-4-(3-phenylpropylamino)pyrrolidin-3-yl]methyl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3701182; SCHEMBL10325876; BDBM172320; US9090589, 2
Click to Show/Hide
|
||||
| Activity |
Ki = 609000 nM
|
[42] | |||
| Compound Name |
1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-methylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798072
Click to Show/Hide
|
||||
| Activity |
IC50 = 710000 nM
|
[37] | |||
| Compound Name |
1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-ethylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798324
Click to Show/Hide
|
||||
| Activity |
IC50 = 770000 nM
|
[37] | |||
| Compound Name |
1-[3-(2-Aminophenyl)-3-hydroxypropyl]-3-propylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799119
Click to Show/Hide
|
||||
| Activity |
IC50 = 880000 nM
|
[37] | |||
| Compound Name |
1-[3-(2-Amino-5-chlorophenyl)-3-hydroxypropyl]-3-propylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799105
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[37] | |||
| Compound Name |
(R)-5-Acetimidoylamino-2-(S)-amino-3-methyl-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370170; BDBM50167726
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
6-Methyl-arginine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8709503; CHEMBL1161638
Click to Show/Hide
|
||||
| Activity |
Ki = 1400000 nM
|
[39] | |||
| Compound Name |
(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416103
Click to Show/Hide
|
||||
| Activity |
IC50 > 1850000 nM
|
[43] | |||
| Compound Name |
2,7-Diamino-7-iminoheptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Heptanoic acid, 2,7-diamino-7-imino-; CHEMBL369349; 6-Amidino-2-aminohexanoic acid; Heptanoic acid, 2,7-diamino-7-imino-, (+-)-; SCHEMBL1286242; CTK1A8016; DTXSID20947004; 7-amino-2-azaniumyl-7-iminoheptanoate
Click to Show/Hide
|
||||
| Activity |
Ki > 3000000 nM
|
[39] | |||
| Compound Name |
(2S)-2-Amino-5-[carbamoyl(methyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408088; SCHEMBL12493127; BDBM50375815
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[44] | |||
| Compound Name |
1-Amino-3-phenyl-8-fluoro-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL414608; 8-fluoro-3-phenyl-3,4-dihydroisoquinolin-1-amine; SCHEMBL8063228; BDBM50098932; 8-Fluoro-3-phenyl-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000000 nM
|
[38] | |||
| Compound Name |
3-Cyclopropyl-3,4-dihydroisoquinolin-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7931; SCHEMBL8057421; BDBM50098934; 3-Cyclopropyl-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000000 nM
|
[38] | |||
| Compound Name |
1-Amino-3-(4-fluorophenyl)-8-chloro-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267075; SCHEMBL8056723; BDBM50098935; 8-chloro-3-(4-fluorophenyl)-3,4-dihydroisoquinolin-1-amine; 8-Chloro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000000 nM
|
[38] | |||
| Compound Name |
1-Amino-3-(4-fluorophenyl)-8-fluoro-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7945; SCHEMBL8058500; 8-fluoro-3-(4-fluorophenyl)-3,4-dihydroisoquinolin-1-amine; BDBM50098940; 8-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000000 nM
|
[38] | |||
| Compound Name |
1-Amino-3-(2-thiazolyl)-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL274402; SCHEMBL8045532; BDBM50098939; 3-Thiazol-2-yl-3,4-dihydro-isoquinolin-1-ylamine; 3-(1,3-thiazol-2-yl)-3,4-dihydroisoquinolin-1-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 880000000 nM
|
[38] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 = 170000000 nM
|
[38] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. | ||||
| REF 2 | Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. | ||||
| REF 3 | Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1975-8. | ||||
| REF 4 | N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J Med Chem. 1998 Jul 16;41(15):2858-71. | ||||
| REF 5 | Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. | ||||
| REF 6 | Inhibition of nitric oxide synthase by benzoxazolones. Bioorg Med Chem Lett. 1997 Nov 18;7(22):2887-92. | ||||
| REF 7 | 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6. | ||||
| REF 8 | Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):3037-40. | ||||
| REF 9 | Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine. Eur J Med Chem. 2012 Sep;55:94-107. | ||||
| REF 10 | Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. J Med Chem. 2011 Oct 27;54(20):7408-16. | ||||
| REF 11 | Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem. 1997 Jun 6;40(12):1901-5. | ||||
| REF 12 | First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. J Med Chem. 2012 Apr 12;55(7):3488-501. | ||||
| REF 13 | US patent application no. 8586620B2, Substituted indole compounds having NOS inhibitory activity | ||||
| REF 14 | NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with -Opioid Agonist Activity. ACS Med Chem Lett. 2012 Jan 30;3(3):227-31. | ||||
| REF 15 | Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold. Medchemcomm. 2011;2:201-5. | ||||
| REF 16 | 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1980-4. | ||||
| REF 17 | US patent application no. 8618286B2, Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity | ||||
| REF 18 | 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5234-8. | ||||
| REF 19 | Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg Med Chem Lett. 2000 Mar 20;10(6):597-600. | ||||
| REF 20 | 1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5301-4. | ||||
| REF 21 | 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate. J Med Chem. 2012 Mar 22;55(6):2882-93. | ||||
| REF 22 | 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase. J Med Chem. 1998 Sep 10;41(19):3675-83. | ||||
| REF 23 | US patent application no. 20020111493A1, Amidino compounds useful as nitric oxide synthase inhibitors | ||||
| REF 24 | Dihydroquinolines as novel n-NOS inhibitors. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2561-4. | ||||
| REF 25 | Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase. Bioorg Med Chem Lett. 1997 Jul 8;7(13):1763-8. | ||||
| REF 26 | Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. J Med Chem. 2012 Jan 26;55(2):943-55. | ||||
| REF 27 | 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J Med Chem. 2004 Jun 3;47(12):3320-3. | ||||
| REF 28 | Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6888-94. | ||||
| REF 29 | Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101. | ||||
| REF 30 | Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS). Bioorg Med Chem Lett. 2012 Apr 1;22(7):2510-3. | ||||
| REF 31 | Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. J Med Chem. 2011 Aug 11;54(15):5562-75. | ||||
| REF 32 | Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4228-32. | ||||
| REF 33 | Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J Med Chem. 2009 May 14;52(9):3047-62. | ||||
| REF 34 | Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose. J Nat Prod. 2012 Jul 27;75(7):1383-92. | ||||
| REF 35 | Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. J Med Chem. 2005 Jul 28;48(15):4783-92. | ||||
| REF 36 | Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2881-5. | ||||
| REF 37 | N,N'-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase. Medchemcomm. 2016;7:667-78. | ||||
| REF 38 | 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1023-6. | ||||
| REF 39 | L-arginine analogs as alternate substrates for nitric oxide synthase. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3934-41. | ||||
| REF 40 | Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2573-6. | ||||
| REF 41 | Selectively nonselective kinase inhibition: striking the right balance. J Med Chem. 2010 Feb 25;53(4):1413-37. | ||||
| REF 42 | US patent application no. 9090589B2, Specific nNOS inhibitors for the therapy and prevention of human melanoma | ||||
| REF 43 | Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. J Med Chem. 2002 Apr 11;45(8):1686-9. | ||||
| REF 44 | N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system. Bioorg Med Chem. 2008 Mar 1;16(5):2305-12. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.