Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T03634 | Target Info | |||
| Target Name | CREB-binding protein (CREBBP) | ||||
| Synonyms |
CREBbinding protein; CBP
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| Target Type | Clinical trial Target | ||||
| Gene Name | CREBBP | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 29 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID26394986-Compound-44
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Patented | Compound Info | ||
| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-(4-Benzoyl-1-phenyl-1H-pyrazole-3-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1087680; BDBM50311454; ZINC36651847; MCULE-4986786687
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Coumarin, 3-amino-4-(1-pyrrolidinyl)-
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Investigative | Compound Info | ||
| Synonyms |
3-Amino-4-(1-pyrrolidinyl)coumarin; MLS000711271; SMR000281038; 3-amino-4-pyrrolidin-1-ylchromen-2-one; 3-amino-4-(1-pyrrolidinyl)-2H-chromen-2-one; Oprea1_023545; Oprea1_166100; cid_43001; 3-amino-4-pyrrolidino-coumarin; CHEMBL1594894; BDBM67263; CTK5A9724; DTXSID10208010; HMS1607M18; HMS2662O16; ZINC272726; 3-amino-4-pyrrolidinylchromen-2-one; CCG-15144; AKOS000636150; MCULE-5427441435; NCGC00245228-01; 3-azanyl-4-pyrrolidin-1-yl-chromen-2-one; ST50006656; 3-AMINO-4-(PYRROLIDIN-1-YL)COUMARIN; 3-amino-4-pyrrolidin-1-yl-2H-chromen-2-one; 3-amino-4-(1-pyrrolidinyl)-1-benzopyran-2-one; 3-Amino-4-(pyrrolidin-1-yl)-2H-chromen-2-one; AH-262/31958012; SR-01000390145; 3-Amino-4-(1-pyrrolidinyl)-2H-1-benzopyran-2-one; SR-01000390145-1
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-Acetylbenzimidazole-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4168537; BDBM50311452; SBB072020; ZINC40546446; AKOS023556231; 1-acetyl-1H-benzimidazole-2-carbonitrile; 1-Acetyl-1H-benzoimidazole-2-carbonitrile; ST45027360; J3.620.430C
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4162464
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Investigative | Compound Info | ||
| Synonyms |
ZINC211339; BDBM50311453; AKOS000623718; CCG-311026; MCULE-2192796433; EU-0082690; ST50282145; 3-acetyl-1-phenyl-1H-4,5,6,7-tetrahydroindazole; 1-(1-Phenyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)ethan-1-one
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(9-Acetylcarbazol-3-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
N-(9-acetyl-9H-carbazol-3-yl)acetamide; CHEMBL1368966; Oprea1_666304; MLS000698919; HMS2546F20; ZINC4118120; BDBM50311842; AKOS002242673; MCULE-8833091083; SMR000229827; ST50753119; AP-124/40683333; SR-01000109818; SR-01000109818-1
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(1-Acetylindol-3-yl)methyl acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4167293; SCHEMBL7124186; BDBM50311451; (1-acetyl-1H-indol-3-yl)methyl acetate
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4160970
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Investigative | Compound Info | ||
| Synonyms |
BDBM50311834
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4160237
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Investigative | Compound Info | ||
| Synonyms |
BDBM50311456
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-(4-Chlorophenyl)-2-methylphthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4164710; SCHEMBL8864802; BDBM50311831; STK829736; ZINC33756878; AKOS002337388; MCULE-5220998833; ST51065882; 4-(4-chlorophenyl)-2-methyl-1(2H)-phthalazinone; 4-(4-chlorophenyl)-2-methylphthalazin-1(2H)-one; AN-829/14136004; 4-(4-chlorophenyl)-2-methyl-2-hydrophthalazin-1-one
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Coumarin, 3-amino-4-anilino-
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Investigative | Compound Info | ||
| Synonyms |
3-amino-4-anilino-2H-chromen-2-one; CHEMBL1549374; 3-Amino-4-anilinocoumarin; BRN 1649246; Oprea1_362448; Oprea1_544299; MLS000058813; CTK5A9723; DTXSID00208009; HMS2417B11; ZINC254947; BDBM50311457; AKOS000636096; 3-amino-4-(phenylamino)chromen-2-one; MCULE-2206365262; SDCCGMLS-0038969.P002; 3-AMINO-4-(PHENYLAMINO)COUMARIN; SMR000069079; 3-Amino-4-anilino-2H-1-benzopyran-2-one; ST50989359; AH-034/32475055
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3,4-Diacetyl-5-methyl-1-phenylpyrazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3443736; BDBM50311837; STK699142; ZINC15084657; AKOS005530637; MCULE-6381842341; ST092112; 1,1'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)diethanone; 1,1'-(1-Phenyl-5-methyl-1H-pyrazole-3,4-diyl)bisethanone; 1-(3-acetyl-5-methyl-1-phenyl-1H-pyrazol-4-yl)-1-ethanone
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[3-(3,4-Dihydro-2H-quinolin-1-yl)propyl]-2-methyl-3-oxo-4H-1,4-benzoxazine-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754735; SCHEMBL18199626
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| Activity |
IC50 = 51000 nM
|
[3] | |||
| Compound Name |
Chembl4291134
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468911; MCULE-3578611835; 6-oxo-N-[2-(6-oxo-3-phenylpyridazin-1(6H)-yl)ethyl]piperazine-2-carboxamide
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| Activity |
IC50 = 55000 nM
|
[4] | |||
| Compound Name |
1-[3-(3,5-Dimethyl-1,2-oxazol-4-yl)phenyl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1828980; BDBM50353590
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| Activity |
IC50 = 55700 nM
|
[5] | |||
| Compound Name |
(2E)-4-[(5-Acetyl-2-methoxyphenyl)amino]-4-oxobut-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770026; SCHEMBL17395847; SCHEMBL17395849; (E)-4-(5-acetyl-2-methoxyanilino)-4-oxobut-2-enoic acid; ZINC6857180; BBL019328; BDBM50148559; MFCD09269722; STK279146; AKOS022060445; H6881
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| Activity |
IC50 = 60000 nM
|
[6] | |||
| Compound Name |
2-[(5-Acetyl-2-ethoxyphenyl)carbamoyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3771157; SCHEMBL17395818; BDBM50148564
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| Activity |
IC50 = 64000 nM
|
[6] | |||
| Compound Name |
4-(3-Ethoxyphenyl)-3,5-dimethyl-1,2-oxazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1828981; BDBM50353591
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| Activity |
IC50 = 86900 nM
|
[5] | |||
| Compound Name |
Methyl indole-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
Methyl 1H-indole-3-carboxylate; Indole-3-carboxylic Acid Methyl Ester; Methyl 3-indolecarboxylate; 1H-Indole-3-carboxylic acid, methyl ester; 3-carbomethoxyindole; 3-methoxycarbonylindole; 1H-Indole-3-carboxylic acid methyl ester; methylindole-3-carboxylate; MFCD00189407; Indole-3-carboxylic acid, methyl ester; CHEMBL2270066; 3-carbomethoxy indole; PubChem7506; ACMC-209rqq; methyl indole 3-carboxylate; 3-methoxycarbonyl-1H-indole; KSC490C1F; SCHEMBL1093530; CTK3J0112; KS-00000BOI; ZINC66126; DTXSID10343334; HMS1661G01; Methyl 1H-indole-3-carboxylate #; Methyl indole-3-carboxylate, 99%; BCP00917; CS-D1229; ANW-40224; BBL010669; BDBM50250885; HTS001783; METHYL INDOLE-3- CARBOXYLATE; SBB012373; STK397421; AKOS000579454; MCULE-1094551134; SDCCGMLS-0065824.P001; AK-47146; SC-46735; SC-63798; ST066881; SY020043; AB0021789; FT-0628332; I0491; W1078; I-2505; M-5770; 7T-1502; Q27133581; Z57164966; F2190-0648
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| Activity |
IC50 = 99000 nM
|
[7] | |||
| Compound Name |
4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059509; BDBM50249797
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-4-(5-Acetyl-2-fluoroanilino)-4-oxobut-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3769540; BDBM50148561
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(E)-4-(5-Acetyl-2-methylanilino)-4-oxobut-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3769841; BDBM50148560
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Methyl-6-amino-2(3H)-benzothiazolone
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Investigative | Compound Info | ||
| Synonyms |
6-Amino-3-methylbenzo[d]thiazol-2(3H)-one; 6-AMINO-3-METHYL-2,3-DIHYDRO-1,3-BENZOTHIAZOL-2-ONE; CHEMBL4072960; 6-amino-3-methyl-1,3-benzothiazol-2(3H)-one; Oprea1_024205; SCHEMBL3035789; BDBM50250886; MFCD00848405; STL507403; AKOS037489236; 6-amino-3-methyl-2(3H)-benzothiazolone; AS-68875; 6-amino-3-methyl-1,3-benzothiazol-2-one; DB-100479; CS-0060742
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-Acetyl-3,5-dimethyl-N-[2-methyl-5-(1,3,4-oxadiazol-2-yl)phenyl]-1H-pyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775724; BDBM50150938; ZINC47329967; AKOS034579759; MCULE-4764474234; J3.601.415F; Z768032418; N-[2-Methyl-5-(1,3,4-oxadiazole-2-yl)phenyl]-3,5-dimethyl-4-acetyl-1H-pyrrole-2-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[(5-Acetyl-2-ethoxyphenyl)carbamoyl]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3771223; BDBM50148563
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
6-{(5Z)-5-[1-(4-Fluorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221317; ZINC1820778; STK706542; AKOS005178237
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| Activity |
IC50 = 115700 nM
|
[10] | |||
| Compound Name |
(2R)-2-Ethyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3813701; SCHEMBL17680224; BDBM50178202
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| Activity |
IC50 = 120000 nM
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[11] | |||
| Compound Name |
(2S)-2-(Hydroxymethyl)-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3815068; SCHEMBL4905898; BDBM50178201
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| Activity |
IC50 = 130000 nM
|
[11] | |||
| Compound Name |
5-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-1-[2-(Morpholin-4-Yl)ethyl]-2-(2-Phenylethyl)-1h-Benzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3753333; BDBM50238255; J3.528.933J; Q27453097; 1-(2-(4-Morpholinyl)ethyl)-2-(2-phenylethyl)-5-(3,5-dimethylisoxazole-4-yl)-1H-benzoimidazole
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| Activity |
IC50 = 160000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
3-Methyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one; CHEMBL3813890; 2,3-Dihydro-3-methyl-1,5-benzodiazepin-4(5H)-one; F1216-0227; 3-methyl-2,3,4,5-tetrahydro-1,5-benzodiazepin-2(1H)-one; 3-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one; Oprea1_309360; SCHEMBL11658348; CTK6C3642; KS-00003KIT; 3-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one; DTXSID90389992; HMS1683H19; ALBB-017638; 5239AE; BDBM50178205; MFCD00168266; SBB027802; STK866162; AKOS000275345; AKOS016040985; FS-1830; MCULE-7989418370; AB0159584; BB 0219740; FT-0687545; ST50070595; EN300-48621; L-4371; 3-methyl-1H,3H,4H,5H-benzo[b]1,4-diazepin-2-one; 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-3-methyl-; 3-methyl-1H,3H,4H,5H-benzo[b]1,4-diazaperhydroepin-2-one; 3-Methyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one
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| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
3,5 Dimethyl-4-Phenyl-1,2-Oxazole
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Investigative | Compound Info | ||
| Synonyms |
3,5-dimethyl-4-phenyl-1,2-oxazole; CHEMBL1828979; 4-Phenyl 3,5-Dimethyl Isoxazole; Isoxazole, 3,5-dimethyl-4-phenyl-; 3,5-Dimethyl-4-phenylisoxazole; SCHEMBL12134072; DTXSID00416046; BDBM50353589; ZINC33836256; AKOS015951136; Q27457171; Z1939437573
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
1,3,4,5-Tetrahydro-2H-1,5-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one; 1,3,4,5-Tetrahydro-benzo[b][1,4]diazepin-2-one; 1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one; 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one; NSC 11707; 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-; 1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one; CHEMBL3814945; MFCD00612448; 1,3,4,5-Tetrahydrobenzo[b][1,4]diazepin-2-one; NSC11707; Oprea1_427458; Oprea1_532708; SCHEMBL4071447; CTK1H2663; KS-00001ZZQ; DTXSID20279211; ALBB-017852; CS-B1191; ZINC3865934; ANW-64213; BDBM50178206; NSC-11707; SBB045898; STK866161; AKOS000271473; MCULE-9582091420; SDCCGMLS-0065551.P001; AK-45215; AM806818; BR-45215; DA-19095; SY079183; DB-027128; BB 0216543; FT-0657643; ST50070594; W7095; 1H,3H,4H,5H-benzo[b]1,4-diazepin-2-one; EN300-79181; 55T077; S-6034; 4,5-Dihydro-1H-1,5-benzodiazepin-2(3H)-one; 7W-0803; A831499; 1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one; 1,3,4,5-tetrahydro-2H-1,5-benzodiazepine-2-One; 1,3,4,5-Tetrahydrobenzo[b] [1,4]diazepin-2-one; 1H,3H,4H,5H-benzo[b]1,4-diazaperhydroepin-2-one; 2-Oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine; J-514090; 2,6-diazabicyclo[5.4.0]undeca-7,9,11-trien-5-one; F1216-0226
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| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
4,4-Dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3813958; SCHEMBL4910229; 4,4-dimethyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one; BDBM50178203; MFCD21840720; ZINC38887912; AKOS017844130; NE20135; 4,4-dimethyl-3,5-dihydro-1H-1,5-benzodiazepin-2-one; 4,4-dimethyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one; 4,4-dimethyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one; 4,4-dimethyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one
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| Activity |
IC50 > 200000 nM
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[11] | |||
| Compound Name |
Methyl 2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylate; methyl 2-oxo-3H-1,3-benzoxazole-6-carboxylate; CHEMBL4087272; Methyl 2-Oxidanylidene-3~{h}-1,3-Benzoxazole-6-Carboxylate; SCHEMBL2548767; CTK5D6765; DTXSID20502718; 8801AE; BDBM50249042; MFCD12827780; SBB091548; ZINC39247236; AKOS005072819; FD-0742; MCULE-8202412032; KS-0000252R; DA-03245; FT-0681310; Methyl 2-hydroxybenzo[d]oxazole-6-carboxylate; methyl 2-oxo-3-hydrobenzoxazole-6-carboxylate; J-522058
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| Activity |
IC50 = 455000 nM
|
[12] | |||
| Compound Name |
Butyrolactone 3
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347571; (2S,3R)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid; (2S,3R)-4-methylene-5-oxo-2-propyl-3-oxolanecarboxylic acid; CTK8E7544; AOB5007; DTXSID60435253; BDBM50371233; ZINC14724235; AKOS006290263; BRD-K68584490-001-01-2; Q27216229; 2beta-Propyl-4-methylene-5-oxotetrahydrofuran-3alpha-carboxylic acid
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| Activity |
IC50 = 500000 nM
|
[13] | |||
| Compound Name |
(2R,3R)-4-Methylidene-5-oxo-3-propyloxolane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3775750; BDBM50151657
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| Activity |
IC50 = 500000 nM
|
[1] | |||
| Compound Name |
2-[5-(3,5-Dimethyl-1,2-oxazol-4-yl)-2-(2-phenylethyl)benzimidazol-1-yl]-N,N-dimethylethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752301
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| Activity |
IC50 = 500000 nM
|
[3] | |||
| Compound Name |
3-Methyl-3,4-dihydro-1H-quinoxalin-2-one
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Investigative | Compound Info | ||
| Synonyms |
3-methyl-3,4-dihydro-2(1H)-quinoxalinone; 3-Methyl-3,4-dihydroquinoxalin-2(1H)-one; 3-methyl-1,2,3,4-tetrahydroquinoxalin-2-one; 3-methyl-1,3,4-trihydroquinoxalin-2-one; ACMC-1AIFD; Oprea1_141365; SCHEMBL1101924; SCHEMBL8314713; CHEMBL4211780; CTK4H1699; DTXSID00377067; ALBB-031489; ANW-27782; MFCD00231317; SBB056026; AKOS003000534; AKOS016050409; 2J-532S; MCULE-6958625418; PB10143; KS-000004U2; AB0002634; DB-068931; 3-Methyl-3,4-dihydroquinoxaline-2(1H)-one; CS-0051283; FT-0680203; ST50448175; V5300; 2(1H)-Quinoxalinone,3,4-dihydro-3-methyl-; C-4101; 10.14272/BEAJCHFCYQOFGS-UHFFFAOYSA-N.1; (3RS)-3-Methyl-3,4-dihydroquinoxalin-2(1H)-one; doi:10.14272/BEAJCHFCYQOFGS-UHFFFAOYSA-N.1; J-512846; Z1295543908
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| Activity |
IC50 = 1900000 nM
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[14] | |||
| Compound Name |
(4s)-4-Methyl-1,3,4,5-tetrahydro-2h-1,5-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3814706; SCHEMBL17680234; CTK8E0436; ZINC152520; BDBM50178208; TS-02442; 4alpha-Methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
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| Activity |
IC50 > 2000000 nM
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[11] | |||
| Compound Name |
1-Methyl-2-pyrrolidinone
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Investigative | Compound Info | ||
| Synonyms |
N-Methylpyrrolidone; N-Methyl-2-pyrrolidone; 1-methylpyrrolidin-2-one; Methylpyrrolidone; 1-Methyl-2-pyrrolidone; N-Methyl-2-pyrrolidinone; M-Pyrol; N-Methylpyrrolidinone; 1-Methylpyrrolidone; 2-Pyrrolidinone, 1-methyl-; 1-Methylpyrrolidinone; n-methyl-pyrrolidone; 1-Methylazacyclopentan-2-one; 1-Methyl-5-pyrrolidinone; N-methylpyrrolidin-2-one; N-Methyl-gamma-butyrolactam; N-methyl pyrrolidone; 1-methylpyrrolidine-2-one; N-methyl pyrrolidinone; Methyl-2-pyrrolidinone; 1-methyl-2-pyrrolidon; Methyl pyrrolidone; Methylpyrrolidinone; UNII-JR9CE63FPM; N-Methyl-alpha-pyrrolidone; N-Methylpyrrolidon; NSC 4594; Agsolex 1; N-Methyl-alpha-pyrrolidinone; N-methyl-pyrrolidinone; N-Methyl-2-pyrrolidon; N-Methylpyrrolid-2-one; MFCD00003193; JR9CE63FPM; N-methyl-pyrrolidin-2-one; 1-methyl-pyrrolidin-2-one; N-Methyl-.alpha.-pyrrolidone; CHEMBL12543; N-Methyl-.gamma.-butyrolactam; N-Methyl-.alpha.-pyrrolidinone; DTXSID6020856; NSC-4594; N-Methylpyrrolidinon; 1-Methyl-2-pyrrolidinone, anhydrous; 1-Methyl-2-pyrrolidinone, HPLC Grade; DSSTox_CID_856; N 0131; DSSTox_RID_75828; DSSTox_GSID_20856; pharmasolve; 2-Pyrrolidinone, methyl-; CCRIS 1633; Methylpyrrolidone, N-; HSDB 5022; Pyrrolidinone, methyl-; 1-Methyl-2-pyrrolidinone, 99.5%, for HPLC; Methylpyrrolidone [NF]; 1-Methyl-2-pyrrolidinone, 99.5+%, ACS reagent; 1-Methyl-2-pyrrolidinone, 99+%, for spectroscopy; EINECS 212-828-1; Micropure ultra; AI3-23116; N-methypyrrolidone; Pyrol M; N-methylpirrolidone; 1methylpyrrolidinone; n-methyl pyrrolidon; n-methylbutyrolactam; N-methy pyrrolidone; N-methyl-pyrolidone; N-methyl-pyrrolidon; N-methylpyrolidinone; 1-methylpyrolidinone; Microposit 2001; n-methylpyrollidinone; N-methlypyrrolidinone; N-methyl pirrolidone; N-methyl pyrollidone; N-methyl-pyrollidone; N-methylpyrrolidone-; NMP,SP Grade; 1-methyl pyrrolidone; 1-methyl-pyrrolidone; methyl-2-pyrrolidone; N-methy pyrrolidinone; N-methyl pyrolidinone; N-methyl-pyrolidinone; N-methyl- pyrrolidone; N-methylpyrro-lidinone; N-methylpyrroli-dinone; N-methylpyrrolidin-one; 1-methyl-2pyrrolidone; 1-methyl2-pyrrolidone; 1methyl-2-pyrrolidone; 1-methyl pyrrolidinone; 1-methyl-pyrrolidinone; methylpyrrolidin-2-one; N-methy-2-pyrrolidone; N-methyl 2-pyrolidone; N-methyl-2-pyrolidone; 1-methyl-2-pyrolidone; PubChem17618; N-methyl 2-pyrrolidone; N-methyl-2-pyrollidone; 1-methyl-2-pirrolidone; 1-methyl-2-pyroldinone; 1-methylpyrrolid-2-one; 1methyl-2-pyrrolidinone; ACMC-1CKWA; n-methylpyrrolidine-2one; N-methyl-2-pyrolidinone; N-methyl-2-pyrrolidinon; N-methylpyrolidin-2-one; 1-methy-2-pyrrolidinone; 1-methyl-2-pyrolidinone; N-methyl 2-pyrrolidinone; N-methyl-2-pyrollidinone; N-methyl-pyrrolid-2-one; N-methylpyrollidin-2-one; 1 -methyl-2-pyrrolidone; 1-methyl 2-pyrrolidinone; 1-methyl-2-pyrollidinone; 1-methyl-pyrrolin-2-one; N-Methylpyrrolidone-(2); NMP, N-Methylpyrrolidone; 1-Methyl-pyrrolidin-2one; N-methylpyrrolidine-2-one; WLN: T5NVTJ A; N-methyl -2-pyrrolidinone; 1 -methyl-2-pyrrolidinone; 1-methyl -2-pyrrolidinone; 1-methyl-2- pyrrolidinone; EC 212-828-1; 2-Pyrrolidone, 1-methyl-; 1-methyl-pyrrolidine-2-one; 1-N-methyl-2-pyrrolidinone; N-methyl-pyrrolidin -2-one; KSC201Q7R; 1-Methylazacyclopentane-2-one; GTPL9520; 1-Methyl-2- pyrrolidin-2-one; CTK1A1878; NSC4594; KS-000002OB; ZINC3860621; Tox21_202350; Tox21_300097; 1-Methyl-2-pyrrolidinone, 99.5%; 2447AB; ANW-38658; BDBM50353587; N-Methyl pyrrolidon (Peptide Grade); s6282; SBB060297; STL183295; N-Methyl-2-pyrrolidinone ACS reagent; AKOS000120930; 1-Methyl-2-pyrrolidinone, BioSolv(R); DB12521; MCULE-1381506705; SL 1332; 1-Methyl-2-pyrrolidone, Reagent, ACS; NCGC00247902-01; NCGC00247902-02; NCGC00253935-01; NCGC00259899-01; BR-30156; SC-18144; 1-Methyl-2-pyrrolidinone, 99%, extra pure; 1-Methyl-2-pyrrolidone (Low water content); AM20110252; CS-0017258; FT-0608052; FT-0672137; FT-0698122; FT-0700571; M0418; M3055; ST51046511; 1-Methyl-2-pyrrolidinone, analytical standard; 1-Methyl-2-pyrrolidinone, anhydrous, 99.5%; 1-Methyl-2-pyrrolidinone, for HPLC, >=99%; 1-Methyl-2-pyrrolidinone, for synthesis, 99%; C11118; M 0418; Q33103; Residual Solvent Class 2 - N-Methylpyrrolidone; 1-Methyl-2-pyrrolidinone, ReagentPlus(R), 99%; 17283-EP2272834A1; 17283-EP2272849A1; 17283-EP2275469A1; 17283-EP2287153A1; 17283-EP2287940A1; 17283-EP2289510A1; 17283-EP2289868A1; 17283-EP2289965A1; 17283-EP2295399A2; 17283-EP2298313A1; 17283-EP2298763A1; 17283-EP2298767A1; 17283-EP2298828A1; 17283-EP2301929A1; 17283-EP2301935A1; 17283-EP2301983A1; 17283-EP2305243A1; 17283-EP2305674A1; 17283-EP2308838A1; 17283-EP2308857A1; 17283-EP2308926A1; 17283-EP2309564A1; 17283-EP2309584A1; 17283-EP2311815A1; 17283-EP2311831A1; 17283-EP2314586A1; 17283-EP2314587A1; 32226-EP2301933A1; 32226-EP2311827A1; 32356-EP2298731A1; 32356-EP2301933A1; 32356-EP2311827A1; 33443-EP2287147A2; 33443-EP2292624A1; 33443-EP2295409A1; 33443-EP2301922A1; 33443-EP2308812A2; 33443-EP2311815A1; 34253-EP2269989A1; 34253-EP2270113A1; 34253-EP2272817A1; 34253-EP2272935A1; 34253-EP2277875A2; 34253-EP2292607A2; 34253-EP2298778A1; 34253-EP2305657A2; 34253-EP2308492A1; 34253-EP2311850A1; 47604-EP2269983A1; 47604-EP2269984A1; 47604-EP2269990A1; 47604-EP2277875A2; 47604-EP2292227A2; 47604-EP2298770A1; 47604-EP2298774A1; 47604-EP2301921A1; 47604-EP2301926A1; 47604-EP2305642A2; 47604-EP2305650A1; 47604-EP2305667A2; 47604-EP2308861A1; 47604-EP2308880A1; 47604-EP2311811A1; 49793-EP2272509A1; 49793-EP2272835A1; 49793-EP2272848A1; 49793-EP2274983A1; 49793-EP2277858A1; 49793-EP2283898A1; 49793-EP2292607A2; 49793-EP2295411A1; 49793-EP2298761A1; 49793-EP2305633A1; 49793-EP2305687A1; 49793-EP2308812A2; 49793-EP2308960A1; 49793-EP2311824A1; 49793-EP2311825A1; 49793-EP2380872A1; 72367-EP2279741A2; 72367-EP2287153A1; 72367-EP2287155A1; 72367-EP2292615A1; 72367-EP2295415A1; 72367-EP2298747A1; 72367-EP2308867A2; 72367-EP2308870A2; 77850-EP2272846A1; 77850-EP2277868A1; 77850-EP2277869A1; 77850-EP2277870A1; 77850-EP2284166A1; 77850-EP2292608A1; 77850-EP2292616A1; 77850-EP2298305A1; 77850-EP2298749A1; 77850-EP2305033A1; 77850-EP2308866A1; 78692-EP2277875A2; 78692-EP2292619A1; 78692-EP2305667A2; 78692-EP2305688A1; 78692-EP2375479A1; 85636-EP2292616A1; 85636-EP2298769A1; 85636-EP2305657A2; 107610-EP2272517A1; 107610-EP2298746A1; 108900-EP2281861A2; 108900-EP2298769A1; 139735-EP2269983A1; 139735-EP2269984A1; 139735-EP2292607A2; 153002-EP2280002A1; 153002-EP2287164A1; 153002-EP2289881A1; 2-PYRROLIDONE,1-METHYL MFC5 H9 N1 O1; A842053; 1-Methyl-2-pyrrolidinone, ACS reagent, >=99.0%; 2,5-Dichloro-4,6-dimethyl pyridine-3-carbonitrile; J-504921; J-803017; 1-Methyl-2-pyrrolidinone, biotech. grade, >=99.7%; 1-Methyl-2-pyrrolidinone, p.a., ACS reagent, 99%; F0001-2169
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| Activity |
IC50 = 2300000 nM
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[5] | |||
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| References | Top | ||||
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| REF 1 | KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases. J Med Chem. 2016 Feb 25;59(4):1249-70. | ||||
| REF 2 | Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. Eur J Med Chem. 2018 Mar 10;147:238-252. | ||||
| REF 3 | Fragments in bromodomain drug discovery. Medchemcomm. 2015;6:1587-604. | ||||
| REF 4 | In silico fragment-based drug design with SEED. Eur J Med Chem. 2018 Aug 5;156:907-917. | ||||
| REF 5 | 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J Med Chem. 2011 Oct 13;54(19):6761-70. | ||||
| REF 6 | Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain. J Med Chem. 2016 Feb 25;59(4):1350-6. | ||||
| REF 7 | A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. J Med Chem. 2017 Dec 28;60(24):10151-10171. | ||||
| REF 8 | Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60(2):668-680. | ||||
| REF 9 | Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics. J Med Chem. 2016 Feb 25;59(4):1340-9. | ||||
| REF 10 | Rhodanine carboxylic acids as novel inhibitors of histone acetyltransferases. Medchemcomm. 2012;3:305-11. | ||||
| REF 11 | Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). ACS Med Chem Lett. 2016 Mar 15;7(5):531-6. | ||||
| REF 12 | Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2472-2478. | ||||
| REF 13 | Development of second generation epigenetic agents. Medchemcomm. 2012;3:135-61. | ||||
| REF 14 | Chemical probes and inhibitors of bromodomains outside the BET family. Medchemcomm. 2016 Dec 7;7(12):2246-2264. | ||||
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