Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05849 | Target Info | |||
| Target Name | Gastrin/cholecystokinin type B receptor (CCKBR) | ||||
| Synonyms |
Cholecystokinin-2 receptor; CCKRB; CCK2-R; CCK-BR; CCK-B receptor
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| Target Type | Successful Target | ||||
| Gene Name | CCKBR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 129 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Alprazolam
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Approved | Compound Info | ||
| Synonyms |
Alcelam; Algad; Alpaz; Alplax; Alpram; Alprax; Alprazolamum; Alprazolan; Alpronax; Alprox; Alviz; Alzam; Alzolam; Alzon;Anpress; ApoAlpraz; Azor; Bestrol; Cassadan; Constan; Esparon; Frontal; Helex; Intensol; Ksalol; Mialin; Neurol; Niravam; NovoAlprazol; NuAlpraz; Panistat; Panix; Pharnax; Prazam; Prazolan; Prinox; Ralozam; Relaxol; Restyl; Solanax; Tafil; Tensivan; Tranax; Trankimazin; Tranquinal; Tricalma; Unilan; Valeans; Xanagis; Xanax; Xanolam; Xanor; Zacetin; Zanapam; Zaxan; Zenax; Zolam; Zolan; Zolarem; Zoldac; Zoldax; Zopax; Zopic; Zotran; Alphapharm Brand of Alprazolam; Alprazolam Alphapharm Brand; Alprazolam Apotex Brand; Alprazolam Kenral Brand; Alprazolam Novopharm Brand; Alprazolam Orion Brand; Alprazolam Pfizer Brand; Alprazolam Temmler Brand; Alprazolam extended release tablets; Alprazolam intensol; Alprazolam solution; Apo Alpraz; Apotex Brand of Alprazolam; Arzneimittelwerk Dresden Brand of Alprazolam; Kenral Brand of Alprazolam; Novo Alprazol; Novopharm Brand of Alprazolam; Nu Alpraz; Nu Pharm Brand of Alprazolam; Orion Brand of Alprazolam; Pfizer Brand of Alprazolam; Tafil D; Temmler Brand of Alprazolam; Xanax TS; Xanax XR; D 65MT; D65MT; TGAR01P; Tus 1; U 31889; AP-1002; AZ-002; Alprazolam Nu-Pharm Brand; Alprazolam-d5; Alprazolamum [INN-Latin]; Apo-Alpraz; D-65MT; Gen-Alprazolan; Niravam (TN); Novo-Alprazol; Nu-Alpraz; Nu-Pharm Brand of Alprazolam; Staccato-alprazolam; TUS-1; U-31889; U31,889; Xanax (TN); Xanor (TN); U-31,889; Alprazolam (JP15/USP/INN); Alprazolam [USAN:INN:BAN:JAN]; 8-Chloro-1-methyl-6-(phenyl-d5)-4H-(1,2,4)triazolo[4,3-a][1,4]benzodiazepine; 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine; 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine; 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-alpha)(1,4)benzodiazepine; 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Triazolam
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Approved | Compound Info | ||
| Synonyms |
Clorazolam; Halcion; Hypnostat; Novidorm; Novodorm; Songar; Triazolamum; Trilam; Apo Triazo; Apotex Brand of Triazolam; Gen Triazolam; Genpharm Brand of Triazolam; Gerard Brand of Triazolam; Pfizer Brand of Triazolam; Triazolam Pfizer Brand; TGAR01H; U 33030; Alti-Triazolam; Apo-Triazo; Gen-Triazolam; Halcion (TN); Halcion (triazolam); Hypam (TN); Novo-Triolam; Triazolamum [INN-Latin]; Trilam (TN); U 33,030; U-33030; U33,030; Apo-Triazo (TN); U-33,030; Triazolam (JAN/USP/INN); Triazolam [USAN:BAN:INN:JAN]; 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine; 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine; 8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine; 8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine; 8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
RO-054520
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL13095; 844-11-1; 5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; RO-054520; AC1L4W0W; SCHEMBL11858895; CTK5F2279; DTXSID00233371; ZINC3650317; BDBM50019250; AKOS030555310; Ro-05-4520; 5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; 1-Methyl-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
BETA-CCM
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Investigative | Compound Info | ||
| Synonyms |
beta-CCM; Methyl beta-carboline-3-carboxylate; beta-Carboline-3-carboxylic acid methyl ester; 69954-48-9; 3-Carbomethoxy-beta-carboline; UNII-I2A008F6YL; methyl 9H-pyrido[3,4-b]indole-3-carboxylate; CHEMBL453066; CHEMBL268191; I2A008F6YL; Methyl 9H-Pyrido(3,4-b)indole-3-carboxylate; methyl 9H-beta-carboline-3-carboxylate; 9H-beta-Carboline-3-carboxylic acid methyl ester; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, methyl ester; C13H10N2O2; Beta CCM; Lopac-E-002; Biomol-NT_000273; AC1L32LA; Lopac0_000523; SCHEMBL1066725
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
tifluadom
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Investigative | Compound Info | ||
| Synonyms |
Tifluadom; dl-Tifluadom; Tifluadom [INN]; 83386-35-0; KC 5103; EINECS 280-380-4; Tifluadom (INN); C22H20FN3OS; CHEBI:9591; CHEMBL169703; 81656-30-6; 3-Thiophenecarboxamide, N-((5-(2-fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-2-yl)methyl)-; N-[[5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]thiophene-3-carboxamide; 3-Thiophenecarboxamide,N-[[5-(2-fluorophenyl)- 2,3-dihydro-1-methyl-1H-1,4- benzodiazepin-2-yl]methyl]-; titfluadom
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
CR-2345
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL558614
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| Activity |
IC50 = 120500 nM
|
[5] | |||
| Compound Name |
(3R)-4-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[3-[[3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]-5-methylhexanoyl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL423405; BDBM50020577
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
CCK antagonist synthetic 8
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9526199; CHEMBL1907740; BDBM82391; (3R)-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; 3(R)-[(1H-indol-3-yl)methyl]-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
3,4-Dichloro-N-[1-(dipentylamino)-5-(4-methylpiperazin-1-yl)-1,5-dioxopentan-2-yl]benzamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL537834
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
3-{2-[2-Tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoylamino}-N-(1-carbamoylmethyl-2-phenyl-ethyl)-succinamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143400; CHEMBL151729; BDBM50020570
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
(3R)-3-[[2-[[(2R)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-[3-[(2-methylphenyl)carbamoylamino]phenyl]propanoyl]amino]-4-[[(2S)-1-amino-3-(4-methylphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302027; BDBM50407326
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| Activity |
IC50 = 50118.72 nM
|
[8] | |||
| Compound Name |
2-Chloro-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72841; 2-Chloro-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide; SCHEMBL643128; BDBM50019185; 3-(RS)-(o-Chlorobenzoylamino)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 2-Chloro-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide. 0.02CHCl3
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| Activity |
IC50 = 52000 nM
|
[2] | |||
| Compound Name |
(R)-2-Amino-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL307034; 2-Amino-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenyl-propionamide; BDBM50019192
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
Benzyl 4-[[5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methylamino]-4-oxobutanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL343969; BDBM50013198
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
(3R)-1-(Cyclopropylmethyl)-5-(2-fluorophenyl)-3-(1H-indol-3-ylmethyl)-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907737; SCHEMBL9526128; BDBM50367533
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| Activity |
IC50 = 58000 nM
|
[7] | |||
| Compound Name |
N-[(3S)-5-(2-Fluorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907840; SCHEMBL9866187; BDBM50367640
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| Activity |
IC50 = 60000 nM
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[2] | |||
| Compound Name |
1-[(4R)-6-(2-Fluorophenyl)-4-(1H-indol-3-ylmethyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]-N,N-dimethylmethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL300926; BDBM50023141
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| Activity |
IC50 = 60000 nM
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[1] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-[4-[(2-chlorophenyl)carbamoylamino]phenyl]propanoyl]amino]-4-[[(2R)-1-amino-3-(4-methylphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302150; BDBM50407328
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| Activity |
IC50 = 63095.73 nM
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[8] | |||
| Compound Name |
N-(9H-beta-Carbolin-3-yl)-2-(1H-indol-3-yl)-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL353304; SCHEMBL10516830; 2-(1H-indol-3-yl)-N-(9H-pyrido[3,4-b]indol-3-yl)acetamide; BDBM50281703
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| Activity |
IC50 = 67000 nM
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[3] | |||
| Compound Name |
(3R)-1-Methyl-3-[(1-methylindol-3-yl)methyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907724; SCHEMBL9866380; BDBM50367516
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| Activity |
IC50 = 67000 nM
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[7] | |||
| Compound Name |
N-(9H-beta-Carbolin-3-yl)-3-phenyl-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169675; BDBM50281704; L002424
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| Activity |
IC50 = 68000 nM
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[3] | |||
| Compound Name |
CCK-A Agonist 23
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88629; SCHEMBL8814559; BDBM85152
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| Activity |
IC50 = 69183.1 nM
|
[10] | |||
| Compound Name |
(S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-{[(S)-2-[(S)-3-(1H-indol-3-yl)-2-methylamino-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-succinamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL434674; BDBM50040524
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| Activity |
IC50 = 69200 nM
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[11] | |||
| Compound Name |
[1-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL32301; BDBM50024320
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| Activity |
Ki = 70000 nM
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[12] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-, (S)-
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Investigative | Compound Info | ||
| Synonyms |
CCK antagonist synthetic 6; (S)-1,3-Dihydro-7-chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-2H-1,4-benzodiazepin-2-one; SCHEMBL9526220; CHEMBL1907931; BDBM82390; DTXSID70198741; (S)-7-Chloro-3-(1H-indole-3-ylmethyl)-5-phenyl-1H-1,4-benzodiazepine-2(3H)-one
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| Activity |
IC50 = 70000 nM
|
[7] | |||
| Compound Name |
N-(9H-beta-Carbolin-3-yl)-4-chloro-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL353088; SCHEMBL9483048; BDBM50281702; L002418; 4-chloro-N-(9H-pyrido[3,4-b]indol-3-yl)benzamide
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| Activity |
IC50 = 72000 nM
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[3] | |||
| Compound Name |
(3S)-1-Methyl-3-[(2-methylpropanoyl)amino]-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907665; SCHEMBL9868116; BDBM50367630; 2-methyl-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-methylpropanamide
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| Activity |
IC50 = 73000 nM
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[2] | |||
| Compound Name |
Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL343158; SCHEMBL9524932; BDBM50013204
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| Activity |
IC50 = 74000 nM
|
[9] | |||
| Compound Name |
3-Benzyloxycarbonylamino-N-{1-[1-(2-butoxycarbonyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-pentyl}-succinamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL166089; BDBM50024331
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| Activity |
IC50 = 75000 nM
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[13] | |||
| Compound Name |
3-(3-Benzyl-ureido)-N-{1-[1-(2-butoxycarbonyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-pentyl}-succinamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL423260; BDBM50024329
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| Activity |
IC50 = 78000 nM
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[13] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-4-propyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL308756; SCHEMBL9525540; BDBM50019221; N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-4-propylbenzamide; 1,3-Dihydro-5-phenyl-3(RS)-(4-alpha-propylbenzoylamino)-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-5-phenyl-3(RS)-(4-n-propylbenzoylamino)-2H-1,4-benzodiazepin-2-one
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
(3R)-3-(1H-Indol-3-ylmethyl)-5-methyl-1,3-dihydro-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907739; SCHEMBL9526333; BDBM50367519
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| Activity |
IC50 = 80000 nM
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[7] | |||
| Compound Name |
N-{1-[1-(2-Butoxycarbonyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-pentyl}-3-(3-phenyl-propionylamino)-succinamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL351531; BDBM50024333
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| Activity |
IC50 = 81000 nM
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[13] | |||
| Compound Name |
1-Methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73096; 1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-5-phenyl-; 1,3-Dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Dechlorodiazepam; Maybridge1_006601; Oprea1_248381; SCHEMBL877728; CTK4G5012; HMS560E01; ZINC83341; 1-Methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; BDA-250; DTXSID90346661; BDBM50019266; CCG-45615; AKOS022181278; MCULE-9525719354; Ro 5-3464; AS-70597; RH 01461; 5-Phenyl-N-methyl-1,4-benzodiazepin-2-one; CS-0130656; SR-01000635369-1; 1-methyl-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-one; 1-Methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #; 2H-1,4-Benzodiazepin-2-one,1,3-dihydro-1-methyl-5-phenyl-; 1-Methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
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| Activity |
IC50 = 94000 nM
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[2] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[(3R)-3-[[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]methyl]-2,3-dihydroindol-1-yl]-4-methyl-1-oxopentan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092988; BDBM50421826
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-4-pentyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL74170; SCHEMBL9527168; BDBM50019205; N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-4-pentylbenzamide; 1,3-Dihydro-3(RS)-(4-n-pentylbenzoylamino)-5-phenyl-2H-1,4-benzodiazepin-2-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Tert-butyl N-[3-(acetamidomethylsulfanyl)-1-[[5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methylamino]-1-oxopropan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL336256; BDBM50013181
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3S)-7-Chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907932; SCHEMBL9526098; BDBM50367540
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(9H-beta-Carbolin-3-yl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171940; SCHEMBL9481172; N-(beta-Carboline-3-yl)benzamide; BDBM50281714; N-(9H-pyrido[3,4-b]indol-3-yl)benzamide; L002423
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-Chloro-3-naphthalen-1-ylmethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429391; SCHEMBL9525672; BDBM50019799; 7-chloro-3-(naphthalen-1-ylmethyl)-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[(3R)-3-[[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]methyl]-2,3-dihydroindol-1-yl]-4-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092746; BDBM50421827
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-Dimethylamino-N-[5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73745; SCHEMBL9526416; BDBM50019253; 4-(dimethylamino)-N-[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-N,1-N-Diethyl-4-N-[[5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]-2-(trifluoromethyl)benzene-1,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336881; BDBM50013193
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[(3S)-3-[[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]methyl]-2,3-dihydroindol-1-yl]-4-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350230; BDBM50226858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[(3R)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907843; SCHEMBL9865231; BDBM50367644
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N',N'-Diethyl-N-[[5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]methanediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434231; BDBM50013206
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(9H-beta-Carbolin-3-yl)-3-(4-chloro-phenyl)-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169953; BDBM50281705; L002419
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(5-Chloropyrazin-2-ylaminomethyl)-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423918; BDBM50013202; 3-[(5-Chloro-pyrazin-2-ylamino)-methyl]-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
3-[2-(1H-Indol-3-yl)ethylamino]-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL70405; SCHEMBL9526053; BDBM50019244; 3-[2-(1H-Indol-3-yl)-ethylamino]-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one: 0.13CH2Cl2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135405; BDBM50043532; (1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Amino-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306271; SCHEMBL8533212; BDBM50019177; 1,3-dihydro-3(RS)-amino-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-3-(RS)-amino-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-5-(2-fluorophenyl)-3-amino-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-(2'-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-Amino-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one: 0.095CH2Cl2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Tert-butyl N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-[(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)amino]propan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310246; SCHEMBL9524843; BDBM50019198
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3R)-7-Chloro-3-[(2-oxo-1,3-dihydroindol-3-yl)methyl]-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907723; BDBM50367543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3R)-1-Ethyl-5-(2-fluorophenyl)-3-(1H-indol-3-ylmethyl)-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907742; SCHEMBL9526146; BDBM50367541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3S)-4-Amino-3-[[(2S)-5-amino-2-[[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]pentanoyl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2112488; BDBM50421881
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[15] | |||
| Compound Name |
N-[[5-(2-Fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]methyl]thiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140984; SCHEMBL9526470; BDBM50013183
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
(5R)-4-Acetyl-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3,5-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907718; BDBM50367520
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(E)-1-Methyl-5-phenyl-3-thiophen-3-ylmethylene-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL279237; SCHEMBL9525623; SCHEMBL9525635; BDBM50019810
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3R)-3-Amino-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171531; (R)-3-Amino-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; SCHEMBL1835654; (R)-3-Amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; CTK4A2012; 2H-1,4-Benzodiazepin-2-one,3-amino-1,3-dihydro-1-methyl-5-phenyl-, (3S)-; ZINC4375654; BDBM50281710; 1,3-dihydro-1-methyl-3(R)-amino-5-phenyl-2H-1,4-benzodiazepin-2-one; 3(R)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(R)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; (3R)-1-Methyl-3alpha-amino-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3S)-1-Methyl-3-[(cyclohexylcarbonyl)amino]-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907662; SCHEMBL9866322; BDBM50367631; N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]cyclohexanecarboxamide; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-cyclohexanecarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl356110
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143394; BDBM50020568
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
N-[[5-(2-Fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl]-2-hydroxy-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140974; BDBM50013186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3,3'-[Iminobis(methylene)]bis[5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341815; BDBM50013196; Bis[5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one].0.25H2O
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3R)-7-Chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907726; SCHEMBL9526645; BDBM50367521
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-{[5-(2-Fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-amino}-3-phenyl-propionic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141629; BDBM50013191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; 3-amino-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; 3-AMINO-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE; CHEMBL306396; (+)-(3R)-3-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; (-)-(3S)-3-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE; 3-Amino-5-phenyl-1,3-dihydro-benzo(E)(1,4)diazepin-2-one; SCHEMBL642305; CTK7H6184; DTXSID50401326; 3-AMINO-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-; CS-M3233; 0807AA; ANW-58943; BDBM50019183; MFCD01318260; (-)-ISOPROTERENOLHYDROCHLORIDE; AKOS015911309; AB08690; MCULE-6765475818; AK-56098; AS-54966; SC-30425; DB-058984; BB 0260764; FT-0705599; VU0549300-1; A-7465; J-000944; F9995-0129; 2H-1,4-Benzodiazepin-2-one, 3-amino-1,3-dihydro-5-phenyl-; 2H-1,4-Benzodiazepin-2-one,3-amino-1,3-dihydro-5-phenyl-; (+/-)-3-amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; (3RS)-1,3-dihydro-3-amino-5-phenyl-2H-1,4-benzodiazepine-2-one; 1,3-dihydro-3-(RS)-amino-5-phenyl-2H-1,4-benzodiazepin-2-one; 3(R,S)-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 3(RS)-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(RS)-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one; racemic 3-amino-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 3-Amino-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one: 0.56H2O
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907664; SCHEMBL9877101; BDBM50452487
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
[1-(2-Oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308769; BDBM50019282
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3R)-1-Benzyl-7-chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907713; SCHEMBL9526427; BDBM50367531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[5-(2-Fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-4-pentyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL70361; SCHEMBL7593316; BDBM50019248; N-[5-(2-fluorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-4-pentylbenzamide; N-(5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl)-4-pentylbenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Amino-5-(2-fluoro-phenyl)-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72151; 3-Amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-Amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl]-2H-1,4-benzodiazepin-2-one; SCHEMBL3292886; BDBM50019236; 3-amino-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; 3(R,S)-amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; 3-Amino-1,3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1.4-benzodiazepin-2-one; 3-Amino-1.3-dihydro-1-methyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3R)-7-Chloro-5-(2-chlorophenyl)-3-(1H-indol-3-ylmethyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907741; SCHEMBL9526835; BDBM50367547
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(Z)-1-Methyl-5-phenyl-3-thiophen-3-ylmethylene-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20223; SCHEMBL9525630; BDBM50019817
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(R)-4-Dicyclohexylcarbamoyl-4-[(1H-indole-2-carbonyl)-amino]-butyric acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158078; BDBM50014887
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[16] | |||
| Compound Name |
(4R)-6-(2-Fluorophenyl)-4-(1H-indol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL301331; BDBM50023143
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Fluoro-N-[5-(2-fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL139615; SCHEMBL10803682; BDBM50013187; N-[[5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin]-2-ylmethyl]-2-fluorobenzamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(7S)-7-[[(2S,3As,4S)-4-hydroxy-2-methyl-2-(2-methylpropyl)-1-oxo-3,3a-dihydroimidazo[1,2-a]indol-4-yl]methyl]-6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357749; BDBM50121922
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(4R)-6-(2-Fluorophenyl)-4-(1H-indol-3-ylmethyl)-1-(trichloromethyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL51280; SCHEMBL9470247; BDBM50023147
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3R)-4-(4-Chlorobenzoyl)-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3,5-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907722; BDBM50367535
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3R)-3-[(1-Benzylindol-3-yl)methyl]-7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907727; BDBM50367545
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
CCK-A Agonist 26
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89953; SCHEMBL8814460; BDBM85158
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[10] | |||
| Compound Name |
3-[[(3S)-2,3-Dihydro-1H-indol-3-yl]methyl]-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092748; BDBM50421831
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| Activity |
IC50 = 100000 nM
|
[7] | |||
| Compound Name |
(3S)-3-Amino-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171651; (R)-3-Amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one; SCHEMBL2929181; ZINC4375653; BDBM50281708; CS-0116266; (S)-3-Amino-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; (S)-3amino-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one; 3(S)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-(S)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; (3S)-1-Methyl-3beta-amino-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-2-one; 3(S)-(-)-Amino-1,3-dihydro-1-methyl-5-phenyl-2 H-1,4-benzodiazepin-2-one; 3(S)-(-)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3R)-7-Chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3-dihydro-1,4-benzodiazepine-2-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907744; SCHEMBL9525114; BDBM50367537
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-4-trifluoromethylsulfanyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70499; BDBM50019280
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2R)-2-Amino-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL308404; BDBM50019201; 2-Amino-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenyl-propionamide: 0.1H2O
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(2-Amino-4-methyl-1-oxopentyl)-3-((2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)methyl)-2,3-dihydro-1H-indole hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552817; SCHEMBL9868935
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Amino-N-[5-(2-fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-3-(1H-indol-3-yl)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL141786; SCHEMBL9499814; BDBM50013188
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[[5-(2-Fluorophenyl)-1-methyl-2,3,4,5-tetrahydro-1,4-benzodiazepin-2-yl]methyl]thiophene-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL140749; SCHEMBL9500460; BDBM50013195
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907716; SCHEMBL9525412; BDBM50367529
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-Aminomethyl-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL139514; SCHEMBL9526239; BDBM50013201; 3-(aminomethyl)-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one; 1,3-Dihydro-5-(2-fluorophenyl)-3(RS)-aminomethyl-2H-1,4-benzodiazepin-2-one; 3-Aminomethyl-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
[2-(1H-Indol-3-yl)-1-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73535; SCHEMBL9423164; BDBM50019265
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Chloro-N-methyl-N-(1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL431185; SCHEMBL9527023; BDBM50019255
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-pentyl-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907715; SCHEMBL9526706; BDBM50367527
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-3-(phenylmethyl)-, (R)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907712; (R)-1,3-Dihydro-7-chloro-5-phenyl-3-(phenylmethyl)-2H-1,4-benzodiazepin-2-one; SCHEMBL9527025; DTXSID90198743; BDBM50367517; (3R)-3-benzyl-7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; 7-Chloro-1,3-dihydro-3(R)-benzyl-5-phenyl-2H-1,4-benzodiazepin-2-one
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3S)-1-Benzyl-7-chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907929; SCHEMBL9526749; BDBM50367536
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
[5-(2-Fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-carbamic acid isobutyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL336690; SCHEMBL9501135; BDBM50013179; 2-methylpropyl N-[[5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]carbamate
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL308297; Pyrazine-2-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide; Pyrazine-2-carboxylic acid [2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide; SCHEMBL643117; BDBM50019226
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(Acetamidomethylsulfanyl)-N-[[5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL141048; SCHEMBL9499260; BDBM50013205
Click to Show/Hide
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| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
N-[5-(2-Fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL140620; SCHEMBL10797831; BDBM50013197; N-[[5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin]-2-ylmethyl]pyridine-3-carboxamide
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| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
(3R)-7-Chloro-5-phenyl-3-[(4-phenylmethoxyphenyl)methyl]-1,3-dihydro-1,4-benzodiazepin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907732; SCHEMBL9524866; BDBM50367538
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-4-phenylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72670; SCHEMBL9526696; BDBM50019262; 1,3-Dihydro-5-phenyl-3(RS)-(4-phenylbenzoylamino)-2H-1,4-benzodiazepin-2-one; Biphenyl-4-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[[(2R)-5-(4-Fluorophenyl)-1,8-dimethyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]-4-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL304546; BDBM50452659
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
[5-(2-Fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-carbamic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL334933; SCHEMBL9526421; BDBM50013189; benzyl N-[[5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]methyl]carbamate
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| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
CCK antagonist synthetic 7
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907711; SCHEMBL9525602; BDBM82389; BDBM50019785; (R)7-Chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; (S)7-Chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3S)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-1,3-dihydro-1,4-benzodiazepin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907930; SCHEMBL9530042; BDBM50367522
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-[4-[(2-methylphenyl)carbamoylamino]phenyl]propanoyl]amino]-4-[[(2R)-1-amino-3-(4-methylphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408395; BDBM50407325
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
5-(2-Fluoro-phenyl)-3-thiophen-3-yl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21770; SCHEMBL9526370; BDBM50019819; 5-(2-fluorophenyl)-3-thiophen-3-yl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(5-Fluoro-1H-indol-3-ylmethyl)-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430336; BDBM50019804
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-Methyl-1H-indole-2-carboxylic acid (9H-beta-carbolin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169767; SCHEMBL9482818; BDBM50281709; 1-methyl-N-(9H-pyrido[3,4-b]indol-3-yl)indole-2-carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-2-(2-Quinolinylcarbonylamino)-3-(1H-indol-3-yl)-N,N-dipentylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL324652; BDBM50008638; (R)-Quinoline-2-carboxylic acid [1-dipentylcarbamoyl-2-(1H-indol-3-yl)-ethyl]-amide
Click to Show/Hide
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| Activity |
IC50 = 100000 nM
|
[18] | |||
| Compound Name |
[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-carbamic acid benzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140495; SCHEMBL9525572; BDBM50013192; benzyl N-[[5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl]carbamate
Click to Show/Hide
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||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
N-[[5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-2-YL]methyl]phthalimide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL140516; N-((5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-2-yl)methyl)phthalimide; EINECS 301-701-7; CTK5H4709; DTXSID20916619; BDBM50013207; N-[[5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin]-2-ylmethyl]phthalimide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
[5-(2-Fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-(3-trifluoromethyl-phenyl)-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL141051; SCHEMBL9500428; BDBM50013200
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
3,3,3-Trifluoro-N-[5-(2-fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-2-methoxy-2-phenyl-propionamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL139520; SCHEMBL9499684; BDBM50013194
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
9H-Pyrido[3,4-b]indol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Aminonorharman; 3-Amino-9H-pyrido[3,4-b]indole; 3-Amino-beta-carboline; 9H-Pyrido(3,4-b)indol-3-amine; 3-Amino-9H-pyrido(3,4-b)indole; CHEMBL54381; 3-amino-b-carboline; 9H-Pyrido(3,4-b)indole, 3-amino-; beta-Carbolin-3-amine; ACMC-20an9y; beta-carboline-3-ylamine; 9H-beta-Carbolin-3-ylamine; 9H-I(2)-Carbolin-3-ylamine; SCHEMBL1982871; CHEMBL2171526; CTK2H9479; ZINC25302; DTXSID10224356; ZINC1767122; BDBM50001472; MFCD00209818; NSC248005; AKOS006228054; NSC-248005; ST003697; L002417
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3R)-3-[[1-(4-Chlorobenzoyl)indol-3-yl]methyl]-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907721; BDBM50367532
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(6-Fluoro-1H-indol-3-ylmethyl)-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20872; BDBM50019812
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[5-(2-Fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-2-hydroxy-2-phenyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337530; BDBM50013208
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
7-Chloro-3-naphthalen-2-ylmethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20514; SCHEMBL9526175; BDBM50019818; 7-chloro-3-(naphthalen-2-ylmethyl)-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-Chloro-N-[1-(3,3-dimethylbutylamino)-5-(4-methylpiperazin-1-yl)-1,5-dioxopentan-2-yl]benzamide;hydrochloride
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557997
Click to Show/Hide
|
||||
| Activity |
IC50 = 103800 nM
|
[5] | |||
| Compound Name |
N-{1-[2-Tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-pentyl}-3-(3-phenyl-propionylamino)-succinamic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL163253; BDBM50024334
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[13] | |||
| Compound Name |
N-(2-Oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-2,3-dihydro-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306369; SCHEMBL9525698; BDBM50019197
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[2] | |||
| Compound Name |
(1-[(3-[(2,3-Dihydro-2-oxo-5-phenyl-1,4-benzodiazepin-3-yl)methyl]-2,3-dihydro-1H-indol-1-yl) carbonyl]-3-methylbutyl]-carbamic acid-1,1-dimethylethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20683; SCHEMBL9866220; BDBM50019802
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[7] | |||
| Compound Name |
2-Chloro-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907854; SCHEMBL9526717; BDBM50367637; N-[[(3S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin]-3-yl]-2-chlorobenzamide
Click to Show/Hide
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||||
| Activity |
IC50 = 130000 nM
|
[2] | |||
| Compound Name |
4-Methyl-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]pentanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907663; BDBM50367647
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[2] | |||
| Compound Name |
1-Methyl-3-[[(3S)-1-methyl-2,3-dihydroindol-3-yl]methyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092990; BDBM50421828
Click to Show/Hide
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||||
| Activity |
IC50 = 140000 nM
|
[7] | |||
| Compound Name |
CCK-A Agonist 18
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL91986; SCHEMBL8811938; BDBM85151
Click to Show/Hide
|
||||
| Activity |
IC50 = 173780.08 nM
|
[10] | |||
| Compound Name |
3,5-Dichloro-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72616; SCHEMBL9527083; BDBM50019223; 3,5-dichloro-N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)benzamide
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| Activity |
IC50 = 180000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
proglumide
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Phase 2 | Compound Info | ||
| Synonyms |
Milid; Nulsa; W-5219
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| Activity |
IC50 = 900000 nM
|
[16] | |||
| Compound Name |
H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218651; H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H
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| Activity |
IC50 = 7.41E+13 nM
|
[19] | |||
| Compound Name |
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-6-(pent-4-ynoylamino)hexanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386883; BDBM50491640
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| Activity |
IC50 = 4600000 nM
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[20] | |||
| Compound Name |
H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-Boc
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL386186; BDBM50202111
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| Activity |
IC50 = 15135612484 nM
|
[19] | |||
| Compound Name |
(3S)-3-{[(2S)-1-[(2S)-2-{2-[(2R)-2-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanehydrazido]-1-oxo-3-phenylpropan-2-yl]carbamoyl}-3-[(2S)-2-[(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-(1H-indol-2-yl)propanamido]hexanamido]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL414087; BDBM50202108
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||||
| Activity |
IC50 = 1.00E+14 nM
|
[19] | |||
| Compound Name |
(3S)-3-[(2S)-2-[(2R)-2-Amino-3-(1H-indol-2-yl)propanamido]hexanamido]-3-{[(2S)-1-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanehydrazido]-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407198; BDBM50202112
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||||
| Activity |
IC50 = 1.07E+14 nM
|
[19] | |||
| Compound Name |
H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-Boc
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218600; BDBM50202107
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||||
| Activity |
IC50 = 9.12E+14 nM
|
[19] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines. J Med Chem. 1988 Jan;31(1):176-81. | ||||
| REF 2 | Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J Med Chem. 1988 Dec;31(12):2235-46. | ||||
| REF 3 | Multipurpose receptor ligands: beta-carboline cholecystokinin antagonists. Bioorg Med Chem Lett. 1993 May;3(5):867-70. | ||||
| REF 4 | Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors. J Med Chem. 1996 Feb 16;39(4):860-72. | ||||
| REF 5 | Biological properties of (R)-4-benzamido-5-oxopentanoic basic derivatives as CCK-antagonists. Bioorg Med Chem Lett. 1993 May;3(5):861-6. | ||||
| REF 6 | Synthesis of gastrin antagonists, analogues of the C-terminal tetrapeptide of gastrin, by introduction of a beta-homo residue. J Med Chem. 1989 Mar;32(3):522-8. | ||||
| REF 7 | Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists. J Med Chem. 1987 Jul;30(7):1229-39. | ||||
| REF 8 | CCK-A receptor selective antagonists derived from the CCK-A receptor selective tetrapeptide agonist Boc-Trp-Lys(Tac)-Asp-MePhe-NH2 (A-71623). J Med Chem. 1995 Jan 6;38(1):207-11. | ||||
| REF 9 | Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom. J Med Chem. 1990 Jan;33(1):450-5. | ||||
| REF 10 | Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists. J Med Chem. 1997 Aug 15;40(17):2706-25. | ||||
| REF 11 | Tetrapeptide CCK-A agonists: effect of backbone N-methylations on in vitro and in vivo CCK activity. J Med Chem. 1994 Mar 4;37(5):630-5. | ||||
| REF 12 | The design of a dipeptide library for screening at peptide receptor sites. Bioorg Med Chem Lett. 1993 May;3(5):799-802. | ||||
| REF 13 | Synthesis and biological activity of partially modified retro-inverso pseudopeptide derivatives of the C-terminal tetrapeptide of gastrin. J Med Chem. 1987 May;30(5):758-63. | ||||
| REF 14 | Development of 1,4-benzodiazepine cholecystokinin type B antagonists. J Med Chem. 1993 Dec 24;36(26):4276-92. | ||||
| REF 15 | Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists. J Med Chem. 1990 Dec;33(12):3199-204. | ||||
| REF 16 | Novel glutamic acid derived cholecystokinin receptor ligands. J Med Chem. 1990 Feb;33(2):591-5. | ||||
| REF 17 | 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery. J Med Chem. 2002 Dec 19;45(26):5609-16. | ||||
| REF 18 | Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors. J Med Chem. 1991 Dec;34(12):3350-9. | ||||
| REF 19 | Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. | ||||
| REF 20 | Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2422-5. | ||||
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